|
| Status |
Public on Aug 22, 2017 |
| Title |
Expression data from Men1 knockout MEFs |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
|
| Summary |
Multiple endocrine neoplasia type1 (MEN1), an inherited autosomal dominant syndrome characterized by the development of endocrine tumors including NETs, results from mutation in the MEN1 gene that encodes the protein menin. In mouse models, heterozygous loss of Men1 leads to multiple endocrine tumors with loss of heterozygocity at the Men1 locus. Men1 interacts with several partners to regulate cellular processes and gene expression through regulating histone modification.
We used microarrays to detail the global gene expression change in Men1 knockout MEFs and identified up-regulated genes during this process.
|
| |
|
| Overall design |
Men1 knockout mouse embryonic fibroblasts complemented with vector or Men1 were selected for RNA extraction and hybridization on Affymetrix microarrays. We sought to obtain downstream target genes regulated by menin.
|
| |
|
| Contributor(s) |
Feng Z, Hua X |
| Citation(s) |
27872097 |
| Submission date |
Oct 07, 2016 |
| Last update date |
Feb 18, 2018 |
| Contact name |
Xianxin Hua |
| E-mail(s) |
huax@mail.med.upenn.edu
|
| Organization name |
University of Pennsylvania Perelman School of Medicine
|
| Department |
Department of Cancer Biology
|
| Lab |
Hua Lab
|
| Street address |
421 Curie BLVD
|
| City |
philadelphia |
| State/province |
PA |
| ZIP/Postal code |
19104 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL81 |
[MG_U74Av2] Affymetrix Murine Genome U74A Version 2 Array |
|
| Samples (4)
|
|
| Relations |
| BioProject |
PRJNA347287 |
Less...
More...