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| Status |
Public on Apr 01, 2017 |
| Title |
Expression data from precancerous mouse liver under PI3K signaling activation with or without Kdm3a defficiency |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
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| Summary |
Epigenetic gene regulation in various oncogenic pathways is currently an important focus of cancer research. The PI3K pathway plays a pivotal role in hepatocellular carcinoma, but the significance of histone modification in the PI3K pathway-dependent hepatotumorigenesis remains unknown.
We used microarrays to investigate the oncogenic gene regulation by histone demethylase Kdm3a under PI3K signaling activation in the liver.
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| Overall design |
We investigate the role of a histone demethylase KDM3A in liver tumor development by crossing the hepatocyte-specific Pik3ca transgenic mice and the Kdm3a knockout mice. We obtained the material specimen from precancerous liver tissue and analyze it.
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| Contributor(s) |
Nakatsuka T, Tateishi K |
| Citation(s) |
28692045 |
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| Submission date |
Oct 07, 2016 |
| Last update date |
Feb 11, 2019 |
| Contact name |
Takuma Nakatsuka |
| Organization name |
The University of Tokyo
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| Department |
Gastroenterology
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| Street address |
7-3-1, Hongo
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| City |
Bunkyo-ku |
| State/province |
Tokyo |
| ZIP/Postal code |
1138655 |
| Country |
Japan |
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| Platforms (1) |
| GPL1261 |
[Mouse430_2] Affymetrix Mouse Genome 430 2.0 Array |
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| Samples (2) |
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| Relations |
| BioProject |
PRJNA347364 |
