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| Status |
Public on Feb 27, 2004 |
| Title |
Genome-wide regulation by TFIID and SAGA |
| Organism |
Saccharomyces cerevisiae |
| Experiment type |
Expression profiling by array
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| Summary |
TFIID and SAGA share a common set of TAFs, regulate chromatin, and deliver TBP to promoters. Here we examine their relationship within the context of the Saccharomyces cerevisiae genome-wide regulatory network. We find that while TFIID and SAGA make overlapping contributions to the expression of all genes, TFIID function predominates at ~90% and SAGA at ~10% of the measurable genome. Strikingly, SAGA-dominated genes are largely stress-induced and TAF-independent, and are down-regulated by the coordinate action of a variety of chromatin, TBP, and RNA polymerase II regulators. In contrast, the TFIID-dominated class is less regulated, but is highly dependent upon TAFs including those shared between TFIID and SAGA. These two distinct modes of transcription regulation might reflect the need to balance inducible stress responses with the steady output of housekeeping genes.
Keywords = Taf1
Keywords = Spt3
Keywords = Gcn5
Keywords: other
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| Contributor(s) |
Huisinga KL, Pugh B |
| Citation(s) |
14992726 |
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| Submission date |
Dec 11, 2003 |
| Last update date |
Sep 20, 2012 |
| Contact name |
B. Franklin Pugh |
| E-mail(s) |
fp265@cornell.edu, bfp2@psu.edu
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| Organization name |
Cornell University
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| Department |
Molecular Biology and Genetics
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| Lab |
B. Franklin Pugh
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| Street address |
465 Biotechnology Bldg.
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| City |
Ithaca |
| State/province |
NY |
| ZIP/Postal code |
14853 |
| Country |
USA |
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| Platforms (1) |
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| Samples (30)
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| Relations |
| BioProject |
PRJNA87889 |
| Supplementary data files not provided |
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