|
| Status |
Public on Jan 03, 2017 |
| Title |
Oas1b-dependent Immune Transcriptional Profiles of West Nile Virus Infection in the Collaborative Cross |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
|
| Summary |
We studied the cause-effect relationships between the transcriptomics and phenotypic outcomes within the CC-F1 population, which allowed us to identify novel genetic signatures. Our results indicate that Oas1b status as wild type or mutant, and overall Oas1b gene dosage, link with novel innate immune gene signatures that impact specific biological pathways for the control of flavivirus infection and immunity.
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| |
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| Overall design |
Microarrays were performed on spleen samples from mice collected at days 2,4,7,12 post-infection with west nile virus or from mock-infected animals.
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| Contributor(s) |
Green R, Wilkins C, Thomas S, Sekine A, Gale M Jr |
| Citation(s) |
28592649 |
| NIH grant(s) |
| Grant ID |
Grant title |
Affiliation |
Name |
| U19 AI100625 |
Systems Immunogenetics of Biodefense Pathogens in the Collaborative Cross: Unlocking Zika Virus Immune Control and Pathogenesis with the Collaborative Cross |
UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL |
Mark T Heise, Ralph S Baric |
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| |
| Submission date |
Dec 07, 2016 |
| Last update date |
Aug 29, 2019 |
| Contact name |
Michael Gale, Jr |
| E-mail(s) |
uw_galelab_geo@uw.edu
|
| Organization name |
University of Washington
|
| Department |
Immunology
|
| Street address |
750 Republican St. E360, Box 358059
|
| City |
Seattle |
| State/province |
Washington |
| ZIP/Postal code |
98109 |
| Country |
USA |
| |
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| Platforms (1) |
| GPL17400 |
[MoGene-2_1-st] Affymetrix Mouse Gene 2.1 ST Array [transcript (gene) version] |
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| Samples (128)
|
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| Relations |
| BioProject |
PRJNA356625 |
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