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| Status |
Public on Dec 08, 2019 |
| Title |
Screening of differentially expressed circulating microRNAs during osteoporosis |
| Organism |
Homo sapiens |
| Experiment type |
Non-coding RNA profiling by array
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| Summary |
To explore the variation of serum microRNA expression during osteoporosis, we have employed microRNA microarray expression profiling as a discovery platform to identify microRNAs with the potential to diagnose osteoporosis from healthy and osteopenia individuals for clinical use. Whole blood from healthy, osteopenic and osteoporotic donors was collected, and the sera were separated. Twenty two microRNAs (miR-15a-5p, miR-29b-5p, miR-30c-2-3p, miR-145-5p, miR-199a-5p, miR-301a-3p, miR-424-5p, miR-497-5p, miR-526b-5p, miR-550a-5p, miR-575, miR-654-5p, miR-663a, miR-708-5p, miR-877-3p, miR-1246, miR-1260b, miR-1299, miR-1323, miR-4447, miR-4769-3p and miR-5685) were finally used for further detection of osteoporosis diagnosis.
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| Overall design |
Gradually differed microRNAs were measured in healthy, osteopenic and osteoporotic participants. Three independent cohorts were performed to verify the diagnostic performance.
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| Contributor(s) |
Jin Y, Shuai Y |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
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| Submission date |
Dec 08, 2016 |
| Last update date |
Dec 10, 2019 |
| Contact name |
Yat Handsome |
| E-mail(s) |
handsy@126.com
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| Organization name |
Tissue engineering center
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| Street address |
Changle Road
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| City |
Xi'an |
| ZIP/Postal code |
710032 |
| Country |
China |
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| Platforms (1) |
| GPL18402 |
Agilent-046064 Unrestricted_Human_miRNA_V19.0_Microarray (miRNA ID version) |
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| Samples (3) |
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| Relations |
| BioProject |
PRJNA356716 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE91033_RAW.tar |
21.1 Mb |
(http)(custom) |
TAR (of TXT) |
| Processed data included within Sample table |
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