|
| Status |
Public on May 29, 2018 |
| Title |
Loss of JNK in Breast Epithelium Accelerates Tumor Formation |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
Members of the JNK pathway have been found to be mutated in human breast cancer. Mouse studies examining JNK loss in different tissues have demonstrated that the JNK pathway can play a role in cancer. Using and autochthonous mouse model, we found that JNK deficiency on a p53-null background resulted in more rapid tumor onset. To learn more about these tumors we generated cells lines and performed various in vitro assays, as well as RNAseq in hope of finding differentially expressed genes that may explain the differences we observed in vivo.
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| |
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| Overall design |
Tumors were harvested from mice and cells lines were established from them. RNA was isolated from established tumor cell lines.
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| |
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| Contributor(s) |
Girnius N, Davis RJ |
| Citation(s) |
29856313 |
| |
| Submission date |
Dec 19, 2016 |
| Last update date |
May 15, 2019 |
| Contact name |
Dr Yvonne Edwards, PhD |
| Organization name |
University of Massachusetts Medical School
|
| Department |
Program in Molecular Medicine
|
| Lab |
Bioinformatics Core
|
| Street address |
373 Plantation Street
|
| City |
Worcester |
| State/province |
MA |
| ZIP/Postal code |
01605 |
| Country |
USA |
| |
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| Platforms (1) |
| GPL19057 |
Illumina NextSeq 500 (Mus musculus) |
|
| Samples (4)
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| Relations |
| BioProject |
PRJNA358050 |
| SRA |
SRP095341 |
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