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Series GSE93389 Query DataSets for GSE93389
Status Public on Jan 31, 2019
Title small RNA seq profile of DG and CA region of mice subjected to 2 or 10 weeks of environmental enrichment and their respective home cage controls
Organism Mus musculus
Experiment type Non-coding RNA profiling by high throughput sequencing
Summary Physical exercise in combination with cognitive training is known to improve memory function and lower the risk for various complex diseases including Alzheimer’s disease. Here we show that prolonged exposure of mice to such an environmental enrichment paradigm mediates long-lasting beneficial effects on memory function and synaptic plasticity even after the end of enrichment training and also provides a cognitive advantage to the offspring. We furthermore show that this effect is mediated via changes in sperm RNA involving the expression of miR-212/132.
 
Overall design small RNA profile from adult animals (hippocampal DG or CA region) subjected to 2 weeks or 10 weeks of enrvironmental enrichment
 
Contributor(s) Benito-Garagorri E, Kerimoglu C, Fischer A
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Submission date Jan 10, 2017
Last update date May 15, 2019
Contact name Eva Benito Garagorri
E-mail(s) eva.benito@dzne.de
Organization name DZNE Goettingen
Department Epigenetics of Aging
Lab Andre Fischer
Street address Von Siebold Strasse 3A
City Goettingen
State/province Niedersachsen
ZIP/Postal code 37075
Country Germany
 
Platforms (1)
GPL13112 Illumina HiSeq 2000 (Mus musculus)
Samples (52)
GSM2452383 2wHC_CA_1_mm_smallrna
GSM2452384 2wHC_CA_2_mm_smallrna
GSM2452385 2wHC_CA_3_mm_smallrna
Relations
BioProject PRJNA360850
SRA SRP096370

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE93389_RAW.tar 390.0 Kb (http)(custom) TAR (of TXT)
SRA Run SelectorHelp
Raw data are available in SRA
Processed data provided as supplementary file

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