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| Status |
Public on Aug 30, 2017 |
| Title |
Gene expression profiling of cardiomyocyte-enriched populations isolated from mice subject to transverse aortic constriction (TAC) and treated with BIX-01294 for 1 week |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
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| Summary |
The role of the histone mehyltrasferase G9a (also known as Ehmt2) in cardiac hypertrophy has not been studied extensively. To address how G9a promotes cardiac hypertrophy, we assessed the gene expression signature defined by G9a in cardiomyocytes (CM) of mice subject to transverse aortic constriction (TAC) for 1 wk, a surgical procedure that causes cardiac hypertrophy following the induction of pressure overload. To this end, we compared the expression profiles of CMs isolated from mice treated with the G9a inhibitor BIX-01294 and control groups (untreated and DMSO-treated mice at baseline and after TAC). The expression profiles were defined by Illumina arrays .
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| Overall design |
Profiling of the transcriptome of cardiomyocyte-enriched populations isolated from mice subject at transverse aortic constriction (TAC) and treated with BIX-01294 for 1 week. Two biological replicates were profiled for each cell type.
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| Contributor(s) |
Serio S, Papait R, Condorelli G |
| Citation(s) |
28778944 |
| |
| Submission date |
Jan 17, 2017 |
| Last update date |
Jan 16, 2019 |
| Contact name |
Simone Serio |
| E-mail(s) |
simone.serio@humanitasresearch.it
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| Organization name |
Humanitas Research Hospital
|
| Department |
Cardiovascular Medicine
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| Street address |
Via Alessandro Manzoni, 56
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| City |
Rozzano |
| State/province |
Milano |
| ZIP/Postal code |
20089 |
| Country |
Italy |
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| Platforms (1) |
| GPL6887 |
Illumina MouseWG-6 v2.0 expression beadchip |
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| Samples (6)
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| This SubSeries is part of SuperSeries: |
| GSE93754 |
The genomic distribution and gene expression profiling of cardiomyocyte-enriched populations |
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| Relations |
| BioProject |
PRJNA361564 |
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