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| Status |
Public on Mar 22, 2017 |
| Title |
Next Generation Sequencing analysis using splenic DCs freshly isolated from Wild Type and TBK1-DKO mice |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
In this experiment, we analyzed the gene expression profile of WT and TBK1-deficient splenic DCs by RNA sequencing based on three independent samples. The results revealed significant alterations in the expression of a number of genes, most notably the enhanced expression of a large subset of IFN-responsive genes in the TBK1-deficient DCs.
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| Overall design |
Fresh splenic DC mRNA profiles of 8-week old wild type (WT) and TBK1-DKO mice were generated by deep sequencing, in triplicate
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| |
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| Contributor(s) |
Xiao Y, Zou Q, Xie X, Manyam G, Zhang L, Sun S |
| Citation(s) |
28356390 |
| Submission date |
Feb 06, 2017 |
| Last update date |
May 15, 2019 |
| Contact name |
Shao-cong Sun |
| E-mail(s) |
ssun@mdanderson.org
|
| Organization name |
MD Anderson Cancer Center
|
| Department |
Immunology
|
| Lab |
Dr. Sun's Lab
|
| Street address |
7455 Fannin St.
|
| City |
Houston |
| State/province |
TX |
| ZIP/Postal code |
77054 |
| Country |
USA |
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| Platforms (1) |
| GPL21103 |
Illumina HiSeq 4000 (Mus musculus) |
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| Samples (6)
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| Relations |
| BioProject |
PRJNA371452 |
| SRA |
SRP098902 |
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