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| Status |
Public on Mar 31, 2017 |
| Title |
Colon epithelial cells gene expression data of Sphingomyelin synthase 2 knockout colitis mice |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
|
| Summary |
Sphingomyelin synthase (SMS) 2 is the synthetic enzyme of sphingomyelin (SM), which regulates the fluidity and microdomain structure of the plasma membrane. We investigated the effect of SMS2 deficiency on dextran sodium sulfate (DSS)-induced murine colitis, and found suppression of DSS-induced inflammation in SMS2 deficient (SMS2-/-) mice. Results provide insight into the role of SMS2 in inflammation.
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| Overall design |
Colon epithelial cells were isolated from wild-type (WT) and SMS2 knockout mice at day 2 after initiation of DSS treatment or untreated controls. Two independent biologic replicates were performed.
|
| Web link |
http://www.fasebj.org/content/early/2017/05/18/fj.201601225RR.abstract
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| |
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| Contributor(s) |
Hashizume C, Ohnishi T, Okazaki T |
| Citation(s) |
28522594 |
| |
| Submission date |
Feb 07, 2017 |
| Last update date |
Feb 01, 2019 |
| Contact name |
Chieko Hashizume |
| E-mail(s) |
hashizume.c29@gmail.com
|
| Phone |
+81 76 218 8337
|
| Organization name |
Kanazawa Medical University
|
| Department |
Medicine
|
| Lab |
Hematology/Immunology
|
| Street address |
1-1 Daigaku
|
| City |
Uchinada |
| State/province |
N/A |
| ZIP/Postal code |
9200293 |
| Country |
Japan |
| |
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| Platforms (1) |
| GPL23038 |
[Clariom_S_Mouse] Affymetrix Clariom S Assay, Mouse (Includes Pico Assay) |
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| Samples (8)
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| Relations |
| BioProject |
PRJNA371626 |
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