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| Status |
Public on Sep 19, 2017 |
| Title |
Cell origin dictates programming of resident versus recruited macrophages during acute lung injury |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
The primary objective of this study was to compare global differences in transcriptional programming of resident and recruited alveolar macrophages in a time-limited murine model of lung inflammation. We first performed RNA sequencing of the resident and recruited alveolar macrophages from initiation through resolution of LPS-induced lung inflammation in the mouse. Our results indicate that despite existing in a shared environment, cell origin is the major determinant of programming of resident and recruited AMs during an acute inflammatory response. Major areas of difference include cell proliferation, inflammatory cytokine production and metabolism.
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| Overall design |
Comparison of two alveolar macrophage cell types transcriptomes at days 0,3,6,9, and 12 following lung injury.
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| Contributor(s) |
Mould KJ, Janssen WJ, Danhorn T, Leach S, Jakubzick C, Mohning M, McCubbrey A, Thomas S, Bratton D, Fingerlin T, O'Connor B, Reisz J, D'Alessandro A |
| Citation(s) |
28935638, 28421818 |
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| Submission date |
Feb 09, 2017 |
| Last update date |
May 15, 2019 |
| Contact name |
Kara Mould |
| Organization name |
National Jewish Health
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| Department |
Medicine
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| Lab |
Janssen
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| Street address |
1400 Jackson Street
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| City |
Denver |
| State/province |
CO |
| ZIP/Postal code |
80206 |
| Country |
USA |
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| Platforms (1) |
| GPL18635 |
Ion Torrent Proton (Mus musculus) |
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| Samples (27)
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| Relations |
| BioProject |
PRJNA373917 |
| SRA |
SRP099168 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE94749_htseq-genecounts.txt.gz |
834.8 Kb |
(ftp)(http) |
TXT |
| GSE94749_htseq-genecounts_notcounted.txt.gz |
600 b |
(ftp)(http) |
TXT |
SRA Run Selector |
| Raw data are available in SRA |
| Processed data are available on Series record |
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