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| Status |
Public on Feb 28, 2017 |
| Title |
Analysis of microRNA expression profiles in clear cell papillary renal cell carcinoma compared to normal adjacent tissue. |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
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| Summary |
Clear cell papillary renal cell carcinoma (CCPRCC) is a low-grade renal neoplasm with morphological characteristics mimicking both clear cell renal cell carcinoma (CCRCC) and papillary renal cell carcinoma (PRCC). However, despite some overlapping features, their morphological, immunohistochemical, and molecular profiles are distinct. To better understand the biology of this tumor, we analyze the miRNA expression profiles of a set of CCPRCC by microarrays.
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| Overall design |
We analyze the miRNA expression profiles of clear cell papillary renal cell carcinoma (CCPRCC) compared to matched normal renal parenchyma using microarray. We further compare CCPRCC with other RCC histologic subtypes using publicly available datasets, identifying common and distinctive microRNA signatures along with the associated signaling pathways and biological processes.
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| Contributor(s) |
Marchionni L, Munari E, Chitre A, Hayashi M, Martignoni G, Brunelli M, Gobbo S, Argani P, Allaf M, Hoque MO, Netto GJ |
| Citation(s) |
24703100 |
| |
| Submission date |
Feb 26, 2017 |
| Last update date |
Mar 02, 2017 |
| Contact name |
Luigi Marchionni |
| E-mail(s) |
marchion@jhu.edu
|
| Phone |
410-502-8179
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| Organization name |
Johns Hopkins University
|
| Department |
Oncology
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| Lab |
Cancer Biology Program
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| Street address |
1550 Orleans St., CRB2, Room 1M52
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| City |
Baltimore |
| State/province |
MD |
| ZIP/Postal code |
21231 |
| Country |
USA |
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| Platforms (1) |
| GPL16770 |
Agilent-031181 Unrestricted_Human_miRNA_V16.0_Microarray (miRBase release 16.0 miRNA ID version) |
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| Samples (8)
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| GSM2509615 |
Clear cell papillary renal cell carcinoma sample: S_12-36332_Normal |
| GSM2509616 |
Clear cell papillary renal cell carcinoma sample: S_12-36332_Tumor |
| GSM2509617 |
Clear cell papillary renal cell carcinoma sample: S_12-41240_Normal |
| GSM2509618 |
Clear cell papillary renal cell carcinoma sample: S_12-41240_Tumor |
| GSM2509619 |
Clear cell papillary renal cell carcinoma sample: S_11-82070_Normal |
| GSM2509620 |
Clear cell papillary renal cell carcinoma sample: S_11-82070_Tumor |
| GSM2509621 |
Clear cell papillary renal cell carcinoma sample: S_11-243_Normal |
| GSM2509622 |
Clear cell papillary renal cell carcinoma sample: S_11-243_Tumor |
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| Relations |
| BioProject |
PRJNA377085 |
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