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| Status |
Public on Feb 13, 2019 |
| Title |
Sex-biased hippocampal pathology in the 5XFAD mouse model of Alzheimer's disease: A multi-omic analysis |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
Numerous neurological disorders, including Alzheimer's disease, display a sex-biased prevalence. To identify molecular correlates of this sex bias, we investigated sex-differences in molecular pathology in the hippocampus using the 5XFAD mouse model of Alzheimer's disease during early stages of disease progression (1, 2, and 4 months of age).
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| Overall design |
Hippocampal mRNA from 1, 2, and 4 month old male and female 5XFAD mice were analyzed by RNA sequencing of 5 biological replicates using an Illumina HiSeq 2500
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| Contributor(s) |
Bundy JL, Vied C, Dawn-Badger C, Nowakowski RS |
| Citation(s) |
30291623 |
| |
| Submission date |
Mar 28, 2017 |
| Last update date |
May 15, 2019 |
| Contact name |
Joseph Ligon Bundy |
| E-mail(s) |
josephlbundy@gmail.com
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| Organization name |
Florida State University
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| Department |
Department of Biomedical Sciences
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| Lab |
Dr. Richard Nowakowski
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| Street address |
1115 W Call St
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| City |
Tallahassee |
| State/province |
FL |
| ZIP/Postal code |
32304 |
| Country |
USA |
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| Platforms (1) |
| GPL17021 |
Illumina HiSeq 2500 (Mus musculus) |
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| Samples (30)
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| Relations |
| BioProject |
PRJNA380737 |
| SRA |
SRP102581 |
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