 |
 |
GEO help: Mouse over screen elements for information. |
|
| Status |
Public on Apr 11, 2017 |
| Title |
Epigenetic and genetic dissections of UV-induced global gene dysregulation in skin cells through multi-omics analyses |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
Genome binding/occupancy profiling by high throughput sequencing
Other
|
| Summary |
In this study, we performed integrative multi-omics studies to understand the complex mechanisms underlying UV photobiological effects. While H3K27ac and genetic mutations can both contribute to UV-induced transcriptomic changes, additional omics-based studies on other histone modifications, DNA methylation, and whole genome mapping of genetic mutations will provide a thorough understanding of UV-gene interactions in skin disease pathogenesis. The new UV target genes that we identified have important clinical implications in skin carcinogenesis..
|
| |
|
| Overall design |
In this study, we performed RNA-Seq, Chip-Seq and Exome-seq studies to elucidate the molecular mechanisms underlying the photobiological effects of UV radiation on gene regulation in skin homeostasis
|
| |
|
| Contributor(s) |
Shen Y, Liu L |
| Citation(s) |
28211524 |
| |
| Submission date |
Apr 10, 2017 |
| Last update date |
May 15, 2019 |
| Contact name |
Liang Liu |
| Organization name |
Columbia University
|
| Street address |
1150 St. Nicholas Avenue
|
| City |
New York |
| State/province |
NY |
| ZIP/Postal code |
10032 |
| Country |
USA |
| |
|
| Platforms (2) |
| GPL11154 |
Illumina HiSeq 2000 (Homo sapiens) |
| GPL18573 |
Illumina NextSeq 500 (Homo sapiens) |
|
| Samples (9)
|
|
| Relations |
| BioProject |
PRJNA382367 |
| SRA |
SRP103769 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE97577_RAW.tar |
272.1 Mb |
(http)(custom) |
TAR (of BW, CSV, VCF) |
SRA Run Selector |
| Raw data are available in SRA |
| Processed data provided as supplementary file |
|
|
|
|
 |
Less...
More...