|
| Status |
Public on Dec 26, 2018 |
| Title |
Impact of DNA demethylation agents (5-azacitidine or vitamin C) on DNA copy number in gliobalstoma HSR-GBM1 cells |
| Organism |
Homo sapiens |
| Experiment type |
Genome variation profiling by array
|
| Summary |
Glioblastoma HSR-GBM1 cells have low mitochondrial DNA copy numbers which is associated with the abnormal DNA methylation patterns. By inducing DNA demthylation using 5azacitidine and vitamin C, HSR-GBM1 cells modulate their mitochondrial copy number and capability of diffrentiation.
|
| |
|
| Overall design |
HSR-GBM1 cell line with three conditions: untreated control group, treated with 5 azacitidine and treated with vitamin C. 3 biological replicates of each condition.
|
| |
|
| Contributor(s) |
St John J, Sun X, Ziino M |
| Citation(s) |
29722878 |
| |
| Submission date |
May 01, 2017 |
| Last update date |
Jul 25, 2021 |
| Contact name |
Justin C St. John |
| E-mail(s) |
justin.stjohn@hudson.org.au
|
| Phone |
+61399024749
|
| Organization name |
Hudson Institute of Medical Research
|
| Department |
Centre for Genetic Diseases
|
| Lab |
Mitochondrial Genetics
|
| Street address |
27-31 Wright St
|
| City |
Clayton |
| State/province |
Vic |
| ZIP/Postal code |
3168 |
| Country |
Australia |
| |
|
| Platforms (1) |
| GPL23391 |
Infinium Global Screening Array |
|
| Samples (9)
|
|
| This SubSeries is part of SuperSeries: |
| GSE98693 |
Induced DNA demethylation, genome instability and transcription |
|
| Relations |
| BioProject |
PRJNA384932 |
Less...
More...