|
| Status |
Public on Jun 17, 2017 |
| Title |
Role of JunB in Th17 cell effector stability [RNA-seq] |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
Here we identify the activator protein-1 (AP-1) factor JunB as an essential regulator of Th17 cell identity. JunB activates the expression of Th17 lineage-specifying genes, and coordinately represses genes controlling Th1 and Treg fate. Through regulatory analysis, we find that JunB is a core regulator of global transcriptional programs that promote Th17 cell identity and restrict alternative CD4+ T cell potential.
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| |
|
| Overall design |
Examination of differential gene expression in Junb+/+CD4cre and Junbfl/flCD4cre 48 hour in vitro polarized Th17 cell cultures
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| |
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| Contributor(s) |
Carr TM, Wheaton JD, Ciofani M |
| Citation(s) |
28824171 |
| |
| Submission date |
May 01, 2017 |
| Last update date |
May 15, 2019 |
| Contact name |
Maria Ciofani |
| E-mail(s) |
maria.ciofani@duke.edu
|
| Organization name |
Duke University School of Medicine
|
| Department |
Integrative Immunobiology
|
| Street address |
207 Research Drive, 128 Jones Building
|
| City |
Durham |
| State/province |
NC |
| ZIP/Postal code |
27710 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL13112 |
Illumina HiSeq 2000 (Mus musculus) |
|
| Samples (4)
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| This SubSeries is part of SuperSeries: |
| GSE98414 |
Role of JunB in Th17 cell effector stability |
|
| Relations |
| BioProject |
PRJNA385056 |
| SRA |
SRP106220 |
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