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| Status |
Public on Dec 13, 2007 |
| Title |
U2OS ad-HIC1 target identification |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
|
| Summary |
The tumor suppressor gene HIC1 (Hypermethylated in Cancer 1) is essential for mammalian development and is epigenetically silenced in many human tumors. Functionally, HIC1 is involved in a complex pathway regulating P53 tumor-suppression activity. HIC1 encodes a sequence-specific transcriptional repressor containing five Krüppel-like C2H2 zinc fingers but only a few genes regulated by HIC1 have been reported, including SIRT1.
Keywords: Time Series Design
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| Overall design |
We performed genome-wide expression profiling analyses to identify new HIC1 target genes, in U2OS human osteosarcoma cells infected with adenoviruses expressing either HIC1 or GFP as control.
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| |
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| Contributor(s) |
Rood B |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| |
| Submission date |
Dec 12, 2007 |
| Last update date |
Oct 01, 2019 |
| Contact name |
Eric P Hoffman |
| E-mail(s) |
ericphoffman@gmail.com
|
| Organization name |
Binghamton University - SUNY
|
| Department |
Pharmaceutical Sciences
|
| Street address |
PO Box 6000
|
| City |
Binghamton |
| State/province |
NY |
| ZIP/Postal code |
13902 |
| Country |
USA |
| |
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| Platforms (1) |
| GPL96 |
[HG-U133A] Affymetrix Human Genome U133A Array |
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| Samples (19)
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| Relations |
| BioProject |
PRJNA103831 |
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