|
| Status |
Public on Nov 01, 2017 |
| Title |
The BET bromodomain inhibitor CPI203 overcomes resistance to ABT-199 (venetoclax) by downregulation of BFL-1/A1 in in vitro and in vivo models of MYC+/BCL2+ double hit lymphoma |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
|
| Summary |
Double Hit Lymphoma (DHL) were treated with the BRD4 inhibitor 100 nM CPI203 for 6h
We used microarrays to uncover the mechanisms underlying CPI203 activity in Double Hit Lymphoma (DHL)
|
| |
|
| Overall design |
Global RNA expression was done in three DHL cell lines and two DHL patients treated in vitro with CPI203 for 6h
|
| |
|
| Contributor(s) |
Valero JG, Arenys AE, Roué G |
| Citation(s) |
29353886 |
| |
| Submission date |
May 15, 2017 |
| Last update date |
Jul 25, 2021 |
| Contact name |
Juan Garcia Valero |
| E-mail(s) |
GARCIA32@clinic.ub.es
|
| Organization name |
IDIBAPS
|
| Department |
Oncology and haematology
|
| Lab |
Physiopathology and molecular bases in hematology
|
| Street address |
Rosselló, 153
|
| City |
Barcelona |
| State/province |
Barcelona |
| ZIP/Postal code |
08036 |
| Country |
Spain |
| |
|
| Platforms (1) |
| GPL13667 |
[HG-U219] Affymetrix Human Genome U219 Array |
|
| Samples (10)
|
|
| Relations |
| BioProject |
PRJNA386866 |
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