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| Status |
Public on Feb 14, 2008 |
| Title |
Expression data from wildtype and gas-1 mitochondrial mutant C. elegans |
| Organism |
Caenorhabditis elegans |
| Experiment type |
Expression profiling by array
|
| Summary |
Utilizing C. elegans as a model of mitochondrial dysfunction provides insight into cellular adaptations which occur as a consequence of genetic alterations causative of human disease. We characterized genome-wide expression profiles of hypomorhpic C. elegans mutants in nuclear-encoded subunits of respiratory chain complexes I, II and III.
Our goal was to detect concordant changes among clusters of genes that comprise defined metabolic pathways utilizing gene set enrichment analysis.
Keywords: Wildtype vs mutant comparison as a method for studying contributors to disease processes
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| |
|
| Overall design |
5 biological replicates of wildtype and electron transport chain (ETC) mutant C. elegans were used as sources of total RNA, each for hybridization to a single Affymetrix whole-genome microarray. Comparison of the data was intended to reveal metabolic pathways downstream of the mutation.
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| |
|
| Contributor(s) |
Falk M, Zhang Z |
| Citation(s) |
18178500, 19900588 |
| |
| Submission date |
Dec 14, 2007 |
| Last update date |
Oct 28, 2019 |
| Contact name |
Marni J Falk |
| E-mail(s) |
falkm@email.chop.edu
|
| Phone |
215-590-4564
|
| Organization name |
CHOP
|
| Department |
Pediatrics/ Human Genetics
|
| Lab |
ARC 1002c
|
| Street address |
3615 Civic Center Blvd
|
| City |
Philadelphia |
| State/province |
PA |
| ZIP/Postal code |
19104 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL200 |
[Celegans] Affymetrix C. elegans Genome Array |
|
| Samples (10)
|
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| This SubSeries is part of SuperSeries: |
| GSE9967 |
Expression data from wildtype and C. elegan mutants |
|
| Relations |
| BioProject |
PRJNA105143 |
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