|
| Status |
Public on Feb 14, 2008 |
| Title |
Expression data from 2 wildtype and 8 C. elegans ETC mutants |
| Organism |
Caenorhabditis elegans |
| Experiment type |
Expression profiling by array
|
| Summary |
Utilizing C. elegans as a model of mitochondrial dysfunction provides insight into cellular adaptations which occur as a consequence of genetic alterations causative of human disease. We characterized genome-wide expression profiles of hypomorphic C. ele
Our goal was to detect concordant changes among clusters of genes that comprise defined metabolic pathways utilizing gene set enrichment analysis.
Keywords: Wildtype vs mutant comparison as a method for studying contributors to disease processes
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| |
|
| Overall design |
3 biological replicates of each C. elegans strain were used as sources of total RNA combined for hybridization to a single Affymetrix whole-genome microarray. Comparison of the data was intended to reveal metabolic pathways downstream of the mutation.
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| |
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| Contributor(s) |
Falk M, Zhang Z |
| Citation(s) |
18178500, 19900588 |
| |
| Submission date |
Dec 14, 2007 |
| Last update date |
Oct 28, 2019 |
| Contact name |
Marni J Falk |
| E-mail(s) |
falkm@email.chop.edu
|
| Phone |
215-590-4564
|
| Organization name |
CHOP
|
| Department |
Pediatrics/ Human Genetics
|
| Lab |
ARC 1002c
|
| Street address |
3615 Civic Center Blvd
|
| City |
Philadelphia |
| State/province |
PA |
| ZIP/Postal code |
19104 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL200 |
[Celegans] Affymetrix C. elegans Genome Array |
|
| Samples (10)
|
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| This SubSeries is part of SuperSeries: |
| GSE9967 |
Expression data from wildtype and C. elegan mutants |
|
| Relations |
| BioProject |
PRJNA105145 |
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