|
| Status |
Public on Jun 03, 2018 |
| Title |
Glucose competition between immune cells and microbial pathogens controls infections |
| Organisms |
Candida albicans; Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
To understand the dynamic physiological changes in host and pathogen that occur during infection, some of which might be driving the ability of C. albicans to trigger macrophage cell death, we performed dual RNA-seq of C. albicans-infected bone marrow-derived mouse macrophages over a time course. We chose three time points corresponding to: (i) early events post-phagocytosis of C. albicans (approximately 1 h post infection), (ii) fungal escape following caspase 1-dependent pyroptosis (approximately 6 h post infection), and (iii) the transition to the rapid Phase II death (approximately 9 h post-infection).
|
| |
|
| Overall design |
Analysis of dual RNA-seq in C. albicans
|
| |
|
| Contributor(s) |
Traven A, Harrrison PF, Beilharz TH |
| Citation(s) |
29719235 |
| |
| Submission date |
Jun 12, 2017 |
| Last update date |
May 15, 2019 |
| Contact name |
Traude Beilharz |
| E-mail(s) |
traude.beilharz@monash.edu
|
| Organization name |
Monash University
|
| Department |
Biomedicine Discovery Institute
|
| Lab |
RNA Systems Biology Laboratory
|
| Street address |
Wellington Rd
|
| City |
Clayton |
| State/province |
VIC |
| ZIP/Postal code |
3800 |
| Country |
Australia |
| |
|
| Platforms (2) |
| GPL18480 |
Illumina HiSeq 1500 (Mus musculus) |
| GPL23573 |
Illumina HiSeq 1500 (Candida albicans) |
|
| Samples (18)
|
|
| Relations |
| BioProject |
PRJNA390053 |
| SRA |
SRP108976 |
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