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Sample GSM40957

Query DataSets for GSM40957

Status

Public on Feb 06, 2005

Title

heart/muscle-specific MnSOD-deficient mouse (d/d)

Sample type

RNA

Source name

heart

Organism

Mus musculus

Extracted molecule

total RNA

Description

In order to investigate the physiological as well as pathological role of MnSOD in the heart and muscle, we generated conditional MnSOD knockout mice using the Cre-loxP system.

We used MCK-Cre transgenic mice for the selective expression of Cre protein in muscle tissues as shown previously. Crossbreeding of homozygous MnSOD flox mice
(flox/flox, f/f) with MCK-Cre transgenic mice gave rise to heart/muscle-specific MnSOD-deficient mice (del/del, d/d).

Keywords = Mn-SOD
Keywords = manganese superoxide dismutase
Keywords = knockout
Keywords = heart failure
Keywords = heart
Keywords = muscle

Submission date

Feb 03, 2005

Last update date

May 27, 2005

Contact name

Takuji Shirasawa

E-mail(s)

sirasawa@tmig.or.jp

Phone

+81-3-3964-3241

Fax

+81-3-3579-4776

Organization name

Tokyo Metropolitan Institute of Gerontology

Department

Molecular Gerontology

Street address

City

Itabashi-ku

State/province

Tokyo

ZIP/Postal code

173-0015

Country

Japan

Platform ID

GPL1261

Series (1)

GSE2236

heart/muscle-specific MnSOD-deficient mouse

Data table header descriptions
ID_REF
VALUE	signal intensity
ABS_CALL	absent or present
DETECTION P-VALUE	detection p-value

Data table
ID_REF	VALUE	ABS_CALL	DETECTION P-VALUE
AFFX-BioB-5_at	177.1	P	0.000169
AFFX-BioB-M_at	366.6	P	0.000044
AFFX-BioB-3_at	198.8	P	0.000044
AFFX-BioC-5_at	441.8	P	0.00006
AFFX-BioC-3_at	412.1	P	0.000052
AFFX-BioDn-5_at	525.8	P	0.000044
AFFX-BioDn-3_at	2343.3	P	0.000044
AFFX-CreX-5_at	4752.6	P	0.000044
AFFX-CreX-3_at	6413.8	P	0.000044
AFFX-DapX-5_at	398.7	P	0.000044
AFFX-DapX-M_at	616.9	P	0.00006
AFFX-DapX-3_at	730.7	P	0.000044
AFFX-LysX-5_at	26.3	P	0.00006
AFFX-LysX-M_at	53.7	P	0.00039
AFFX-LysX-3_at	89.9	P	0.000052
AFFX-PheX-5_at	66.7	P	0.000052
AFFX-PheX-M_at	61.8	P	0.000081
AFFX-PheX-3_at	79.2	P	0.000081
AFFX-ThrX-5_at	98.4	P	0.000044
AFFX-ThrX-M_at	115.4	P	0.000052

Total number of rows: 45101

Table truncated, full table size 1179 Kbytes.

Supplementary data files not provided