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    ATXN2L ataxin 2 like [ Homo sapiens (human) ]

    Gene ID: 11273, updated on 3-Nov-2024

    Summary

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    Official Symbol
    ATXN2Lprovided by HGNC
    Official Full Name
    ataxin 2 likeprovided by HGNC
    Primary source
    HGNC:HGNC:31326
    See related
    Ensembl:ENSG00000168488 MIM:607931; AllianceGenome:HGNC:31326
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    A2D; A2LG; A2LP; A2RP
    Summary
    This gene encodes an ataxin type 2 related protein of unknown function. This protein is a member of the spinocerebellar ataxia (SCAs) family, which is associated with a complex group of neurodegenerative disorders. Several alternatively spliced transcripts encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
    Expression
    Broad expression in testis (RPKM 66.0), spleen (RPKM 26.9) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See ATXN2L in Genome Data Viewer
    Location:
    16p11.2
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (28822999..28837232)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (29103578..29117815)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (28834320..28848553)

    Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA U13 Neighboring gene ribosomal protein S15a pseudogene 33 Neighboring gene uncharacterized LOC124903672 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:28833599-28834335 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7313 Neighboring gene ReSE screen-validated silencer GRCh37_chr16:28853164-28853321 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10645 Neighboring gene microRNA 4721 Neighboring gene MPRA-validated peak2552 silencer Neighboring gene Tu translation elongation factor, mitochondrial Neighboring gene SH2B adaptor protein 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10646 Neighboring gene Sharpr-MPRA regulatory region 4004 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7314 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:28885274-28885774

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. ATXN2L upregulated by epidermal growth factor promotes gastric cancer cell invasiveness and oxaliplatin resistance. Lin L, et al. Cell Death Dis, 2019 Feb 20. PMID 30787271, Free PMC Article
    2. Identification and expression of the gene for human ataxin-2-related protein on chromosome 16. Figueroa KP, et al. Exp Neurol, 2003 Dec. PMID 14769358
    3. PRMT1-mediated arginine methylation controls ATXN2L localization. Kaehler C, et al. Exp Cell Res, 2015 May 15. PMID 25748791
    4. Moderate expansion of a normally biallelic trinucleotide repeat in spinocerebellar ataxia type 2. Pulst SM, et al. Nat Genet, 1996 Nov. PMID 8896555
    5. Ataxin-2-like is a regulator of stress granules and processing bodies. Kaehler C, et al. PLoS One, 2012. PMID 23209657, Free PMC Article

    See all (166) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ATXN2L promotes cell invasiveness and oxaliplatin resistance and can be upregulated by EGF via PI3K/Akt signaling.
      Title: ATXN2L upregulated by epidermal growth factor promotes gastric cancer cell invasiveness and oxaliplatin resistance.
    2. ATXN2L associates with the protein arginine-N-methyltransferase 1 (PRMT1).
      Title: PRMT1-mediated arginine methylation controls ATXN2L localization.
    3. Observational study of gene-disease association. (HuGE Navigator)
      Title: Association between genome-wide association studies reported SNPs and pediatric-onset Crohn's disease in Canadian children.
    4. cellular ataxin-2 concentration is important for the assembly of stress granules and P-bodies, ataxin-2 interacts with the DEAD/H-box RNA helicase DDX6
      Title: Ataxin-2 interacts with the DEAD/H-box RNA helicase DDX6 and interferes with P-bodies and stress granules.
    Submit: New GeneRIF Correction

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index.
    EBI GWAS Catalog
    Common genetic variants associated with cognitive performance identified using the proxy-phenotype method.
    EBI GWAS Catalog
    Common variants at five new loci associated with early-onset inflammatory bowel disease.
    EBI GWAS Catalog
    GWAS of 126,559 individuals identifies genetic variants associated with educational attainment.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    Pr55(Gag) gag Cellular biotinylated ataxin 2-like protein is incorporated into HIV-1 Gag virus-like particles PubMed
    gag Interaction of HIV-1 Gag with ataxin 2-like (ATXN2L) is identified in a series of six affinity purification/mass spectrometry screens PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables RNA binding HDA PubMed 
    enables cadherin binding HDA PubMed 
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in mRNA metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in stress granule assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasmic stress granule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasmic stress granule IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		  
    located_in membrane HDA PubMed 
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nuclear speck IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    ataxin-2-like protein
    Names
    ataxin 2 related protein
    ataxin-2 domain protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001308230.2 → NP_001295159.1  ataxin-2-like protein isoform 7

      Status: REVIEWED

      Source sequence(s)
      AC116346, AC133550, AC145285
      Consensus CDS
      CCDS76850.1
      UniProtKB/TrEMBL
      H3BUF6
      Related
      ENSP00000457613.1, ENST00000564304.5
      Conserved Domains (3) summary
      COG5180
      Location:209 → 750
      PBP1; PAB1-binding protein PBP1, interacts with poly(A)-binding protein [RNA processing and modification]
      pfam06741
      Location:264 → 326
      LsmAD; LsmAD domain
      pfam14438
      Location:122 → 191
      SM-ATX; Ataxin 2 SM domain

    2. NM_001387166.1 → NP_001374095.1  ataxin-2-like protein isoform 8

      Status: REVIEWED

      Source sequence(s)
      AC116346, AC133550, AC145285
      Conserved Domains (4) summary
      COG5180
      Location:209 → 750
      PBP1; PAB1-binding protein PBP1, interacts with poly(A)-binding protein [RNA processing and modification]
      PRK10263
      Location:667 → 947
      PRK10263; DNA translocase FtsK; Provisional
      pfam06741
      Location:264 → 326
      LsmAD; LsmAD domain
      pfam14438
      Location:123 → 196
      SM-ATX; Ataxin 2 SM domain

    3. NM_001387167.1 → NP_001374096.1  ataxin-2-like protein isoform 3

      Status: REVIEWED

      Source sequence(s)
      AC116346, AC133550, AC145285
      Consensus CDS
      CCDS10640.1
      Conserved Domains (4) summary
      COG5180
      Location:209 → 744
      PBP1; PAB1-binding protein PBP1, interacts with poly(A)-binding protein [RNA processing and modification]
      PRK10263
      Location:661 → 941
      PRK10263; DNA translocase FtsK; Provisional
      pfam06741
      Location:264 → 326
      LsmAD; LsmAD domain
      pfam14438
      Location:123 → 196
      SM-ATX; Ataxin 2 SM domain

    4. NM_001387168.1 → NP_001374097.1  ataxin-2-like protein isoform 3

      Status: REVIEWED

      Source sequence(s)
      AC116346, AC133550, AC145285
      Consensus CDS
      CCDS10640.1
      Conserved Domains (4) summary
      COG5180
      Location:209 → 744
      PBP1; PAB1-binding protein PBP1, interacts with poly(A)-binding protein [RNA processing and modification]
      PRK10263
      Location:661 → 941
      PRK10263; DNA translocase FtsK; Provisional
      pfam06741
      Location:264 → 326
      LsmAD; LsmAD domain
      pfam14438
      Location:123 → 196
      SM-ATX; Ataxin 2 SM domain

    5. NM_001387169.1 → NP_001374098.1  ataxin-2-like protein isoform 9

      Status: REVIEWED

      Source sequence(s)
      AC116346, AC133550, AC145285
      Conserved Domains (4) summary
      COG5180
      Location:209 → 750
      PBP1; PAB1-binding protein PBP1, interacts with poly(A)-binding protein [RNA processing and modification]
      PRK10263
      Location:667 → 947
      PRK10263; DNA translocase FtsK; Provisional
      pfam06741
      Location:264 → 326
      LsmAD; LsmAD domain
      pfam14438
      Location:123 → 196
      SM-ATX; Ataxin 2 SM domain

    6. NM_001387170.1 → NP_001374099.1  ataxin-2-like protein isoform 9

      Status: REVIEWED

      Source sequence(s)
      AC116346, AC133550, AC145285
      Conserved Domains (4) summary
      COG5180
      Location:209 → 750
      PBP1; PAB1-binding protein PBP1, interacts with poly(A)-binding protein [RNA processing and modification]
      PRK10263
      Location:667 → 947
      PRK10263; DNA translocase FtsK; Provisional
      pfam06741
      Location:264 → 326
      LsmAD; LsmAD domain
      pfam14438
      Location:123 → 196
      SM-ATX; Ataxin 2 SM domain

    7. NM_001387171.1 → NP_001374100.1  ataxin-2-like protein isoform 10

      Status: REVIEWED

      Source sequence(s)
      AC116346, AC133550, AC145285
      Conserved Domains (4) summary
      COG5180
      Location:209 → 750
      PBP1; PAB1-binding protein PBP1, interacts with poly(A)-binding protein [RNA processing and modification]
      PRK10263
      Location:815 → 946
      PRK10263; DNA translocase FtsK; Provisional
      pfam06741
      Location:264 → 326
      LsmAD; LsmAD domain
      pfam14438
      Location:123 → 196
      SM-ATX; Ataxin 2 SM domain

    8. NM_001387172.1 → NP_001374101.1  ataxin-2-like protein isoform 11

      Status: REVIEWED

      Source sequence(s)
      AC116346, AC133550, AC145285
      Conserved Domains (4) summary
      COG5180
      Location:209 → 750
      PBP1; PAB1-binding protein PBP1, interacts with poly(A)-binding protein [RNA processing and modification]
      PRK10263
      Location:667 → 947
      PRK10263; DNA translocase FtsK; Provisional
      pfam06741
      Location:264 → 326
      LsmAD; LsmAD domain
      pfam14438
      Location:123 → 196
      SM-ATX; Ataxin 2 SM domain

    9. NM_001387173.1 → NP_001374102.1  ataxin-2-like protein isoform 12

      Status: REVIEWED

      Source sequence(s)
      AC116346, AC133550, AC145285
      Conserved Domains (3) summary
      PHA03247
      Location:398 → 943
      PHA03247; large tegument protein UL36; Provisional
      pfam06741
      Location:264 → 326
      LsmAD; LsmAD domain
      pfam14438
      Location:123 → 196
      SM-ATX; Ataxin 2 SM domain

    10. NM_001387174.1 → NP_001374103.1  ataxin-2-like protein isoform 13

      Status: REVIEWED

      Source sequence(s)
      AC116346, AC133550, AC145285
      Conserved Domains (4) summary
      COG5180
      Location:209 → 744
      PBP1; PAB1-binding protein PBP1, interacts with poly(A)-binding protein [RNA processing and modification]
      PRK10263
      Location:661 → 941
      PRK10263; DNA translocase FtsK; Provisional
      pfam06741
      Location:264 → 326
      LsmAD; LsmAD domain
      pfam14438
      Location:123 → 196
      SM-ATX; Ataxin 2 SM domain

    11. NM_001387175.1 → NP_001374104.1  ataxin-2-like protein isoform 13

      Status: REVIEWED

      Source sequence(s)
      AC116346, AC133550, AC145285
      Conserved Domains (4) summary
      COG5180
      Location:209 → 744
      PBP1; PAB1-binding protein PBP1, interacts with poly(A)-binding protein [RNA processing and modification]
      PRK10263
      Location:661 → 941
      PRK10263; DNA translocase FtsK; Provisional
      pfam06741
      Location:264 → 326
      LsmAD; LsmAD domain
      pfam14438
      Location:123 → 196
      SM-ATX; Ataxin 2 SM domain

    12. NM_001387176.1 → NP_001374105.1  ataxin-2-like protein isoform 13

      Status: REVIEWED

      Source sequence(s)
      AC116346, AC133550, AC145285
      Conserved Domains (4) summary
      COG5180
      Location:209 → 744
      PBP1; PAB1-binding protein PBP1, interacts with poly(A)-binding protein [RNA processing and modification]
      PRK10263
      Location:661 → 941
      PRK10263; DNA translocase FtsK; Provisional
      pfam06741
      Location:264 → 326
      LsmAD; LsmAD domain
      pfam14438
      Location:123 → 196
      SM-ATX; Ataxin 2 SM domain

    13. NM_001387177.1 → NP_001374106.1  ataxin-2-like protein isoform 13

      Status: REVIEWED

      Source sequence(s)
      AC116346, AC133550, AC145285
      Conserved Domains (4) summary
      COG5180
      Location:209 → 744
      PBP1; PAB1-binding protein PBP1, interacts with poly(A)-binding protein [RNA processing and modification]
      PRK10263
      Location:661 → 941
      PRK10263; DNA translocase FtsK; Provisional
      pfam06741
      Location:264 → 326
      LsmAD; LsmAD domain
      pfam14438
      Location:123 → 196
      SM-ATX; Ataxin 2 SM domain

    14. NM_001387178.1 → NP_001374107.1  ataxin-2-like protein isoform 14

      Status: REVIEWED

      Source sequence(s)
      AC116346, AC133550, AC145285
      Related
      ENST00000563314.5
      Conserved Domains (3) summary
      PHA03247
      Location:398 → 943
      PHA03247; large tegument protein UL36; Provisional
      pfam06741
      Location:264 → 326
      LsmAD; LsmAD domain
      pfam14438
      Location:123 → 196
      SM-ATX; Ataxin 2 SM domain

    15. NM_001387179.1 → NP_001374108.1  ataxin-2-like protein isoform 15

      Status: REVIEWED

      Source sequence(s)
      AC116346, AC133550, AC145285
      Conserved Domains (4) summary
      COG5180
      Location:209 → 720
      PBP1; PAB1-binding protein PBP1, interacts with poly(A)-binding protein [RNA processing and modification]
      PRK10263
      Location:637 → 917
      PRK10263; DNA translocase FtsK; Provisional
      pfam06741
      Location:264 → 326
      LsmAD; LsmAD domain
      pfam14438
      Location:123 → 196
      SM-ATX; Ataxin 2 SM domain

    16. NM_001387180.1 → NP_001374109.1  ataxin-2-like protein isoform 16

      Status: REVIEWED

      Source sequence(s)
      AC116346, AC133550, AC145285
      Conserved Domains (3) summary
      PHA03247
      Location:398 → 936
      PHA03247; large tegument protein UL36; Provisional
      pfam06741
      Location:264 → 326
      LsmAD; LsmAD domain
      pfam14438
      Location:123 → 196
      SM-ATX; Ataxin 2 SM domain

    17. NM_001387181.1 → NP_001374110.1  ataxin-2-like protein isoform 17

      Status: REVIEWED

      Source sequence(s)
      AC116346, AC133550, AC145285
      Conserved Domains (5) summary
      COG5180
      Location:209 → 750
      PBP1; PAB1-binding protein PBP1, interacts with poly(A)-binding protein [RNA processing and modification]
      PRK10263
      Location:815 → 946
      PRK10263; DNA translocase FtsK; Provisional
      pfam03154
      Location:740 → 1059
      Atrophin-1; Atrophin-1 family
      pfam06741
      Location:264 → 326
      LsmAD; LsmAD domain
      pfam14438
      Location:123 → 196
      SM-ATX; Ataxin 2 SM domain

    18. NM_001387182.1 → NP_001374111.1  ataxin-2-like protein isoform 18

      Status: REVIEWED

      Source sequence(s)
      AC116346, AC133550, AC145285
      Conserved Domains (4) summary
      PHA03247
      Location:674 → 1060
      PHA03247; large tegument protein UL36; Provisional
      COG5180
      Location:209 → 750
      PBP1; PAB1-binding protein PBP1, interacts with poly(A)-binding protein [RNA processing and modification]
      pfam06741
      Location:264 → 326
      LsmAD; LsmAD domain
      pfam14438
      Location:123 → 196
      SM-ATX; Ataxin 2 SM domain

    19. NM_001387183.1 → NP_001374112.1  ataxin-2-like protein isoform 19

      Status: REVIEWED

      Source sequence(s)
      AC116346, AC133550, AC145285
      Conserved Domains (3) summary
      PHA03247
      Location:398 → 943
      PHA03247; large tegument protein UL36; Provisional
      pfam06741
      Location:264 → 326
      LsmAD; LsmAD domain
      pfam14438
      Location:123 → 196
      SM-ATX; Ataxin 2 SM domain

    20. NM_001387184.1 → NP_001374113.1  ataxin-2-like protein isoform 20

      Status: REVIEWED

      Source sequence(s)
      AC116346, AC133550, AC145285
      Conserved Domains (3) summary
      PHA03247
      Location:398 → 943
      PHA03247; large tegument protein UL36; Provisional
      pfam06741
      Location:264 → 326
      LsmAD; LsmAD domain
      pfam14438
      Location:123 → 196
      SM-ATX; Ataxin 2 SM domain

    21. NM_001387185.1 → NP_001374114.1  ataxin-2-like protein isoform 21

      Status: REVIEWED

      Source sequence(s)
      AC116346, AC133550, AC145285
      Conserved Domains (4) summary
      COG5180
      Location:209 → 720
      PBP1; PAB1-binding protein PBP1, interacts with poly(A)-binding protein [RNA processing and modification]
      PRK10263
      Location:637 → 917
      PRK10263; DNA translocase FtsK; Provisional
      pfam06741
      Location:264 → 326
      LsmAD; LsmAD domain
      pfam14438
      Location:123 → 196
      SM-ATX; Ataxin 2 SM domain

    22. NM_001387186.1 → NP_001374115.1  ataxin-2-like protein isoform 22

      Status: REVIEWED

      Source sequence(s)
      AC116346, AC133550, AC145285
      Conserved Domains (4) summary
      COG5180
      Location:209 → 720
      PBP1; PAB1-binding protein PBP1, interacts with poly(A)-binding protein [RNA processing and modification]
      PRK10263
      Location:785 → 916
      PRK10263; DNA translocase FtsK; Provisional
      pfam06741
      Location:264 → 326
      LsmAD; LsmAD domain
      pfam14438
      Location:123 → 196
      SM-ATX; Ataxin 2 SM domain

    23. NM_001387187.1 → NP_001374116.1  ataxin-2-like protein isoform 23

      Status: REVIEWED

      Source sequence(s)
      AC116346, AC133550, AC145285

    24. NM_001387188.1 → NP_001374117.1  ataxin-2-like protein isoform 24

      Status: REVIEWED

      Source sequence(s)
      AC116346, AC133550, AC145285
      Conserved Domains (4) summary
      PHA03247
      Location:644 → 1013
      PHA03247; large tegument protein UL36; Provisional
      COG5180
      Location:209 → 720
      PBP1; PAB1-binding protein PBP1, interacts with poly(A)-binding protein [RNA processing and modification]
      pfam06741
      Location:264 → 326
      LsmAD; LsmAD domain
      pfam14438
      Location:123 → 196
      SM-ATX; Ataxin 2 SM domain

    25. NM_001387189.1 → NP_001374118.1  ataxin-2-like protein isoform 25

      Status: REVIEWED

      Source sequence(s)
      AC116346, AC133550, AC145285
      Conserved Domains (4) summary
      COG5180
      Location:209 → 750
      PBP1; PAB1-binding protein PBP1, interacts with poly(A)-binding protein [RNA processing and modification]
      PRK10263
      Location:667 → 947
      PRK10263; DNA translocase FtsK; Provisional
      pfam06741
      Location:264 → 326
      LsmAD; LsmAD domain
      pfam14438
      Location:123 → 196
      SM-ATX; Ataxin 2 SM domain

    26. NM_001387190.1 → NP_001374119.1  ataxin-2-like protein isoform 26

      Status: REVIEWED

      Source sequence(s)
      AC116346, AC133550, AC145285

    27. NM_001387191.1 → NP_001374120.1  ataxin-2-like protein isoform 27

      Status: REVIEWED

      Source sequence(s)
      AC116346, AC133550, AC145285
      Conserved Domains (4) summary
      PHA03247
      Location:398 → 943
      PHA03247; large tegument protein UL36; Provisional
      PRK10263
      Location:865 → 1035
      PRK10263; DNA translocase FtsK; Provisional
      pfam06741
      Location:264 → 326
      LsmAD; LsmAD domain
      pfam14438
      Location:123 → 196
      SM-ATX; Ataxin 2 SM domain

    28. NM_001387192.1 → NP_001374121.1  ataxin-2-like protein isoform 28

      Status: REVIEWED

      Source sequence(s)
      AC116346, AC133550, AC145285
      Conserved Domains (3) summary
      PHA03247
      Location:398 → 943
      PHA03247; large tegument protein UL36; Provisional
      pfam06741
      Location:264 → 326
      LsmAD; LsmAD domain
      pfam14438
      Location:123 → 196
      SM-ATX; Ataxin 2 SM domain

    29. NM_001387193.1 → NP_001374122.1  ataxin-2-like protein isoform 29

      Status: REVIEWED

      Source sequence(s)
      AC116346, AC133550, AC145285
      Conserved Domains (4) summary
      COG5180
      Location:209 → 750
      PBP1; PAB1-binding protein PBP1, interacts with poly(A)-binding protein [RNA processing and modification]
      PRK10263
      Location:667 → 947
      PRK10263; DNA translocase FtsK; Provisional
      pfam06741
      Location:264 → 326
      LsmAD; LsmAD domain
      pfam14438
      Location:123 → 196
      SM-ATX; Ataxin 2 SM domain

    30. NM_001387194.1 → NP_001374123.1  ataxin-2-like protein isoform 30

      Status: REVIEWED

      Source sequence(s)
      AC116346, AC133550, AC145285
      Conserved Domains (3) summary
      PHA03247
      Location:398 → 943
      PHA03247; large tegument protein UL36; Provisional
      pfam06741
      Location:264 → 326
      LsmAD; LsmAD domain
      pfam14438
      Location:123 → 196
      SM-ATX; Ataxin 2 SM domain

    31. NM_001387195.1 → NP_001374124.1  ataxin-2-like protein isoform 31

      Status: REVIEWED

      Source sequence(s)
      AC116346, AC133550, AC145285
      Conserved Domains (4) summary
      COG5180
      Location:209 → 744
      PBP1; PAB1-binding protein PBP1, interacts with poly(A)-binding protein [RNA processing and modification]
      PRK10263
      Location:661 → 941
      PRK10263; DNA translocase FtsK; Provisional
      pfam06741
      Location:264 → 326
      LsmAD; LsmAD domain
      pfam14438
      Location:123 → 196
      SM-ATX; Ataxin 2 SM domain

    32. NM_001387196.1 → NP_001374125.1  ataxin-2-like protein isoform 31

      Status: REVIEWED

      Source sequence(s)
      AC116346, AC133550, AC145285
      Conserved Domains (4) summary
      COG5180
      Location:209 → 744
      PBP1; PAB1-binding protein PBP1, interacts with poly(A)-binding protein [RNA processing and modification]
      PRK10263
      Location:661 → 941
      PRK10263; DNA translocase FtsK; Provisional
      pfam06741
      Location:264 → 326
      LsmAD; LsmAD domain
      pfam14438
      Location:123 → 196
      SM-ATX; Ataxin 2 SM domain

    33. NM_001387197.1 → NP_001374126.1  ataxin-2-like protein isoform 32

      Status: REVIEWED

      Source sequence(s)
      AC116346, AC133550, AC145285
      Conserved Domains (4) summary
      PHA03247
      Location:650 → 1033
      PHA03247; large tegument protein UL36; Provisional
      COG5180
      Location:209 → 726
      PBP1; PAB1-binding protein PBP1, interacts with poly(A)-binding protein [RNA processing and modification]
      pfam06741
      Location:264 → 326
      LsmAD; LsmAD domain
      pfam14438
      Location:123 → 196
      SM-ATX; Ataxin 2 SM domain

    34. NM_001387198.1 → NP_001374127.1  ataxin-2-like protein isoform 31

      Status: REVIEWED

      Source sequence(s)
      AC116346, AC133550, AC145285
      Conserved Domains (4) summary
      COG5180
      Location:209 → 744
      PBP1; PAB1-binding protein PBP1, interacts with poly(A)-binding protein [RNA processing and modification]
      PRK10263
      Location:661 → 941
      PRK10263; DNA translocase FtsK; Provisional
      pfam06741
      Location:264 → 326
      LsmAD; LsmAD domain
      pfam14438
      Location:123 → 196
      SM-ATX; Ataxin 2 SM domain

    35. NM_001387199.1 → NP_001374128.1  ataxin-2-like protein isoform 33

      Status: REVIEWED

      Source sequence(s)
      AC116346, AC133550, AC145285
      Conserved Domains (4) summary
      COG5180
      Location:209 → 721
      PBP1; PAB1-binding protein PBP1, interacts with poly(A)-binding protein [RNA processing and modification]
      PRK10263
      Location:638 → 918
      PRK10263; DNA translocase FtsK; Provisional
      pfam06741
      Location:264 → 326
      LsmAD; LsmAD domain
      pfam14438
      Location:123 → 196
      SM-ATX; Ataxin 2 SM domain

    36. NM_001387200.1 → NP_001374129.1  ataxin-2-like protein isoform 34

      Status: REVIEWED

      Source sequence(s)
      AC116346, AC133550, AC145285
      Conserved Domains (4) summary
      COG5180
      Location:209 → 726
      PBP1; PAB1-binding protein PBP1, interacts with poly(A)-binding protein [RNA processing and modification]
      PRK10263
      Location:643 → 923
      PRK10263; DNA translocase FtsK; Provisional
      pfam06741
      Location:264 → 326
      LsmAD; LsmAD domain
      pfam14438
      Location:123 → 196
      SM-ATX; Ataxin 2 SM domain

    37. NM_001387202.1 → NP_001374131.1  ataxin-2-like protein isoform 35

      Status: REVIEWED

      Source sequence(s)
      AC116346, AC133550, AC145285
      Conserved Domains (4) summary
      COG5180
      Location:209 → 720
      PBP1; PAB1-binding protein PBP1, interacts with poly(A)-binding protein [RNA processing and modification]
      PRK10263
      Location:637 → 917
      PRK10263; DNA translocase FtsK; Provisional
      pfam06741
      Location:264 → 326
      LsmAD; LsmAD domain
      pfam14438
      Location:123 → 196
      SM-ATX; Ataxin 2 SM domain

    38. NM_001387203.1 → NP_001374132.1  ataxin-2-like protein isoform 36

      Status: REVIEWED

      Source sequence(s)
      AC116346, AC133550, AC145285
      Conserved Domains (3) summary
      PRK10263
      Location:598 → 878
      PRK10263; DNA translocase FtsK; Provisional
      PRK14971
      Location:338 → 489
      PRK14971; DNA polymerase III subunit gamma/tau
      pfam14438
      Location:123 → 196
      SM-ATX; Ataxin 2 SM domain

    39. NM_001387204.1 → NP_001374133.1  ataxin-2-like protein isoform 37

      Status: REVIEWED

      Source sequence(s)
      AC116346, AC133550, AC145285
      Conserved Domains (3) summary
      PHA03247
      Location:398 → 979
      PHA03247; large tegument protein UL36; Provisional
      pfam06741
      Location:264 → 326
      LsmAD; LsmAD domain
      pfam14438
      Location:123 → 196
      SM-ATX; Ataxin 2 SM domain

    40. NM_007245.4 → NP_009176.2  ataxin-2-like protein isoform 1

      See identical proteins and their annotated locations for NP_009176.2

      Status: REVIEWED

      Source sequence(s)
      AC116346, AC133550, AC145285
      Consensus CDS
      CCDS10641.1
      UniProtKB/Swiss-Prot
      A8K1R6, B9EGM2, E9PAR9, O95135, Q63ZY4, Q6NVJ8, Q6PJW6, Q8IU61, Q8IU95, Q8WWM3, Q8WWM4, Q8WWM5, Q8WWM6, Q8WWM7, Q99703
      Related
      ENSP00000338718.4, ENST00000336783.9
      Conserved Domains (3) summary
      COG5180
      Location:209 → 744
      PBP1; PAB1-binding protein PBP1, interacts with poly(A)-binding protein [RNA processing and modification]
      pfam06741
      Location:264 → 326
      LsmAD; LsmAD domain
      pfam14438
      Location:122 → 191
      SM-ATX; Ataxin 2 SM domain

    41. NM_017492.4 → NP_059867.3  ataxin-2-like protein isoform 6

      See identical proteins and their annotated locations for NP_059867.3

      Status: REVIEWED

      Source sequence(s)
      AC116346, AC133550, AC145285
      Consensus CDS
      CCDS58443.1
      Related
      ENSP00000454516.1, ENST00000570200.5
      Conserved Domains (3) summary
      COG5180
      Location:209 → 744
      PBP1; PAB1-binding protein PBP1, interacts with poly(A)-binding protein [RNA processing and modification]
      pfam06741
      Location:264 → 326
      LsmAD; LsmAD domain
      pfam14438
      Location:122 → 191
      SM-ATX; Ataxin 2 SM domain

    42. NM_145714.3 → NP_663760.1  ataxin-2-like protein isoform 2

      See identical proteins and their annotated locations for NP_663760.1

      Status: REVIEWED

      Source sequence(s)
      AC116346, AC133550, AC145285
      Consensus CDS
      CCDS32423.1
      Related
      ENSP00000315650.6, ENST00000325215.10
      Conserved Domains (4) summary
      COG5180
      Location:209 → 744
      PBP1; PAB1-binding protein PBP1, interacts with poly(A)-binding protein [RNA processing and modification]
      pfam03153
      Location:757 → 941
      TFIIA; Transcription factor IIA, alpha/beta subunit
      pfam06741
      Location:264 → 326
      LsmAD; LsmAD domain
      pfam14438
      Location:122 → 191
      SM-ATX; Ataxin 2 SM domain

    43. NM_148414.3 → NP_680780.1  ataxin-2-like protein isoform 3

      See identical proteins and their annotated locations for NP_680780.1

      Status: REVIEWED

      Source sequence(s)
      AC116346, AC133550, AC145285
      Consensus CDS
      CCDS10640.1
      Related
      ENSP00000378917.2, ENST00000395547.6
      Conserved Domains (4) summary
      COG5180
      Location:209 → 744
      PBP1; PAB1-binding protein PBP1, interacts with poly(A)-binding protein [RNA processing and modification]
      PRK10263
      Location:661 → 941
      PRK10263; DNA translocase FtsK; Provisional
      pfam06741
      Location:264 → 326
      LsmAD; LsmAD domain
      pfam14438
      Location:123 → 196
      SM-ATX; Ataxin 2 SM domain

    44. NM_148415.3 → NP_680781.1  ataxin-2-like protein isoform 4

      See identical proteins and their annotated locations for NP_680781.1

      Status: REVIEWED

      Source sequence(s)
      AC116346, AC133550, AC145285
      Consensus CDS
      CCDS10639.1
      Related
      ENSP00000341459.8, ENST00000340394.12
      Conserved Domains (2) summary
      pfam06741
      Location:264 → 326
      LsmAD; LsmAD domain
      pfam14438
      Location:122 → 191
      SM-ATX; Ataxin 2 SM domain

    45. NM_148416.3 → NP_680782.1  ataxin-2-like protein isoform 5

      See identical proteins and their annotated locations for NP_680782.1

      Status: REVIEWED

      Source sequence(s)
      AC116346, AC133550, AC145285
      Consensus CDS
      CCDS45451.1
      Related
      ENSP00000372133.4, ENST00000382686.8
      Conserved Domains (4) summary
      COG5180
      Location:209 → 744
      PBP1; PAB1-binding protein PBP1, interacts with poly(A)-binding protein [RNA processing and modification]
      pfam03153
      Location:757 → 941
      TFIIA; Transcription factor IIA, alpha/beta subunit
      pfam06741
      Location:264 → 326
      LsmAD; LsmAD domain
      pfam14438
      Location:122 → 191
      SM-ATX; Ataxin 2 SM domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

      Range
      28822999..28837232
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011545719.3 → XP_011544021.1  ataxin-2-like protein isoform X1

      See identical proteins and their annotated locations for XP_011544021.1

      Conserved Domains (5) summary
      COG5180
      Location:209 → 750
      PBP1; PAB1-binding protein PBP1, interacts with poly(A)-binding protein [RNA processing and modification]
      PRK10263
      Location:815 → 946
      PRK10263; DNA translocase FtsK; Provisional
      pfam03154
      Location:740 → 1094
      Atrophin-1; Atrophin-1 family
      pfam06741
      Location:264 → 326
      LsmAD; LsmAD domain
      pfam14438
      Location:123 → 196
      SM-ATX; Ataxin 2 SM domain

    2. XM_054328429.1 → XP_054184404.1  ataxin-2-like protein isoform X1

    3. XM_006721011.2 → XP_006721074.1  ataxin-2-like protein isoform X4

      See identical proteins and their annotated locations for XP_006721074.1

      Conserved Domains (4) summary
      COG5180
      Location:209 → 750
      PBP1; PAB1-binding protein PBP1, interacts with poly(A)-binding protein [RNA processing and modification]
      pfam03153
      Location:763 → 948
      TFIIA; Transcription factor IIA, alpha/beta subunit
      pfam06741
      Location:264 → 326
      LsmAD; LsmAD domain
      pfam14438
      Location:122 → 191
      SM-ATX; Ataxin 2 SM domain

    4. XM_047433529.1 → XP_047289485.1  ataxin-2-like protein isoform X4

    5. XM_047433528.1 → XP_047289484.1  ataxin-2-like protein isoform X4

    6. XM_006721012.5 → XP_006721075.1  ataxin-2-like protein isoform X4

      See identical proteins and their annotated locations for XP_006721075.1

      Conserved Domains (4) summary
      COG5180
      Location:209 → 750
      PBP1; PAB1-binding protein PBP1, interacts with poly(A)-binding protein [RNA processing and modification]
      pfam03153
      Location:763 → 948
      TFIIA; Transcription factor IIA, alpha/beta subunit
      pfam06741
      Location:264 → 326
      LsmAD; LsmAD domain
      pfam14438
      Location:122 → 191
      SM-ATX; Ataxin 2 SM domain

    7. XM_047433527.1 → XP_047289483.1  ataxin-2-like protein isoform X4

    8. XM_005255074.2 → XP_005255131.1  ataxin-2-like protein isoform X3

      Conserved Domains (4) summary
      COG5180
      Location:209 → 750
      PBP1; PAB1-binding protein PBP1, interacts with poly(A)-binding protein [RNA processing and modification]
      pfam03153
      Location:763 → 948
      TFIIA; Transcription factor IIA, alpha/beta subunit
      pfam06741
      Location:264 → 326
      LsmAD; LsmAD domain
      pfam14438
      Location:122 → 191
      SM-ATX; Ataxin 2 SM domain

    9. XM_047433530.1 → XP_047289486.1  ataxin-2-like protein isoform X5

    10. XM_047433526.1 → XP_047289482.1  ataxin-2-like protein isoform X2

    11. XM_047433536.1 → XP_047289492.1  ataxin-2-like protein isoform X11

    12. XM_047433533.1 → XP_047289489.1  ataxin-2-like protein isoform X8

    13. XM_047433531.1 → XP_047289487.1  ataxin-2-like protein isoform X6

    14. XM_047433532.1 → XP_047289488.1  ataxin-2-like protein isoform X7

    15. XM_047433535.1 → XP_047289491.1  ataxin-2-like protein isoform X10

    16. XM_047433537.1 → XP_047289493.1  ataxin-2-like protein isoform X12

    17. XM_047433540.1 → XP_047289496.1  ataxin-2-like protein isoform X15

    18. XM_047433534.1 → XP_047289490.1  ataxin-2-like protein isoform X9

    19. XM_047433541.1 → XP_047289497.1  ataxin-2-like protein isoform X16

    20. XM_047433544.1 → XP_047289500.1  ataxin-2-like protein isoform X19

    21. XM_047433542.1 → XP_047289498.1  ataxin-2-like protein isoform X17

    22. XM_047433545.1 → XP_047289501.1  ataxin-2-like protein isoform X20

    23. XM_047433543.1 → XP_047289499.1  ataxin-2-like protein isoform X18

    24. XM_047433538.1 → XP_047289494.1  ataxin-2-like protein isoform X13

    25. XM_047433549.1 → XP_047289505.1  ataxin-2-like protein isoform X23

    26. XM_047433546.1 → XP_047289502.1  ataxin-2-like protein isoform X21

    27. XM_047433539.1 → XP_047289495.1  ataxin-2-like protein isoform X14

    28. XM_047433548.1 → XP_047289504.1  ataxin-2-like protein isoform X22

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060940.1 Alternate T2T-CHM13v2.0

      Range
      29103578..29117815
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054379450.1 → XP_054235425.1  ataxin-2-like protein isoform X4

    2. XM_054379455.1 → XP_054235430.1  ataxin-2-like protein isoform X5

    3. XM_054379462.1 → XP_054235437.1  ataxin-2-like protein isoform X11

    4. XM_054379464.1 → XP_054235439.1  ataxin-2-like protein isoform X12

    5. XM_054379442.1 → XP_054235417.1  ataxin-2-like protein isoform X1

    6. XM_054379443.1 → XP_054235418.1  ataxin-2-like protein isoform X1

    7. XM_054379441.1 → XP_054235416.1  ataxin-2-like protein isoform X1

    8. XM_054379444.1 → XP_054235419.1  ataxin-2-like protein isoform X1

    9. XM_054379446.1 → XP_054235421.1  ataxin-2-like protein isoform X25

    10. XM_054379454.1 → XP_054235429.1  ataxin-2-like protein isoform X4

    11. XM_054379453.1 → XP_054235428.1  ataxin-2-like protein isoform X4

    12. XM_054379451.1 → XP_054235426.1  ataxin-2-like protein isoform X4

    13. XM_054379452.1 → XP_054235427.1  ataxin-2-like protein isoform X4

    14. XM_054379448.1 → XP_054235423.1  ataxin-2-like protein isoform X3

    15. XM_054379449.1 → XP_054235424.1  ataxin-2-like protein isoform X26

    16. XM_054379447.1 → XP_054235422.1  ataxin-2-like protein isoform X2

    17. XM_054379459.1 → XP_054235434.1  ataxin-2-like protein isoform X8

    18. XM_054379456.1 → XP_054235431.1  ataxin-2-like protein isoform X27

    19. XM_054379457.1 → XP_054235432.1  ataxin-2-like protein isoform X28

    20. XM_054379461.1 → XP_054235436.1  ataxin-2-like protein isoform X31

    21. XM_054379445.1 → XP_054235420.1  ataxin-2-like protein isoform X24

    22. XM_054379474.1 → XP_054235449.1  ataxin-2-like protein isoform X42

    23. XM_054379472.1 → XP_054235447.1  ataxin-2-like protein isoform X40

    24. XM_054379473.1 → XP_054235448.1  ataxin-2-like protein isoform X41

    25. XM_054379467.1 → XP_054235442.1  ataxin-2-like protein isoform X35

    26. XM_054379468.1 → XP_054235443.1  ataxin-2-like protein isoform X36

    27. XM_054379463.1 → XP_054235438.1  ataxin-2-like protein isoform X32

    28. XM_054379460.1 → XP_054235435.1  ataxin-2-like protein isoform X30

    29. XM_054379471.1 → XP_054235446.1  ataxin-2-like protein isoform X39

    30. XM_054379470.1 → XP_054235445.1  ataxin-2-like protein isoform X38

    31. XM_054379466.1 → XP_054235441.1  ataxin-2-like protein isoform X34

    32. XM_054379475.1 → XP_054235450.1  ataxin-2-like protein isoform X43

    33. XM_054379465.1 → XP_054235440.1  ataxin-2-like protein isoform X33

    34. XM_054379458.1 → XP_054235433.1  ataxin-2-like protein isoform X29

    35. XM_054379469.1 → XP_054235444.1  ataxin-2-like protein isoform X37

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8WWM7.2 GenPept UniProtKB/Swiss-Prot:Q8WWM7

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