U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Stn1 STN1 subunit of CST complex [ Rattus norvegicus (Norway rat) ]

    Gene ID: 294025, updated on 2-Nov-2024

    Summary

    Official Symbol
    Stn1provided by RGD
    Official Full Name
    STN1 subunit of CST complexprovided by RGD
    Primary source
    RGD:1305637
    See related
    EnsemblRapid:ENSRNOG00000020376 AllianceGenome:RGD:1305637
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Obfc1
    Summary
    Predicted to enable single-stranded telomeric DNA binding activity. Predicted to be involved in negative regulation of telomere maintenance via telomerase; positive regulation of DNA replication; and telomere maintenance via telomere lengthening. Predicted to be located in fibrillar center; intermediate filament cytoskeleton; and nucleoplasm. Predicted to be part of CST complex. Predicted to be active in chromosome, telomeric region. Human ortholog(s) of this gene implicated in melanoma. Orthologous to human STN1 (STN1 subunit of CST complex). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Adrenal (RPKM 43.8), Lung (RPKM 41.2) and 9 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Stn1 in Genome Data Viewer
    Location:
    1q54
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (256336916..256371143, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (246391311..246429844, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (267281786..267315714, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene SH3 and PX domains 2A Neighboring gene uncharacterized LOC102552122 Neighboring gene transfer RNA proline (anticodon AGG) 27 Neighboring gene uncharacterized LOC134485242 Neighboring gene uncharacterized LOC120100048 Neighboring gene uncharacterized LOC120100049 Neighboring gene 40S ribosomal protein S8 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables single-stranded DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables single-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables single-stranded DNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables single-stranded telomeric DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables single-stranded telomeric DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables single-stranded telomeric DNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables telomeric DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables telomeric DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in negative regulation of telomere maintenance via telomerase IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of telomere maintenance via telomerase ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of DNA replication IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of DNA replication ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of DNA replication ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in telomere capping IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in telomere maintenance ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in telomere maintenance ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in telomere maintenance via telomere lengthening IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in telomere maintenance via telomere lengthening IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in telomere maintenance via telomere lengthening ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in telomere maintenance via telomere lengthening ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    part_of CST complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of CST complex IEA
    Inferred from Electronic Annotation
    more info
     
    part_of CST complex ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in chromosome, telomeric region IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in chromosome, telomeric region ISO
    Inferred from Sequence Orthology
    more info
     
    located_in chromosome, telomeric region ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in fibrillar center IEA
    Inferred from Electronic Annotation
    more info
     
    located_in fibrillar center ISO
    Inferred from Sequence Orthology
    more info
     
    located_in intermediate filament cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    located_in intermediate filament cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
     
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    CST complex subunit STN1
    Names
    STN1, CST complex subunit
    oligonucleotide/oligosaccharide-binding fold containing 1
    oligonucleotide/oligosaccharide-binding fold-containing protein 1
    suppressor of cdc thirteen homolog

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001011943.1NP_001011943.1  CST complex subunit STN1

      See identical proteins and their annotated locations for NP_001011943.1

      Status: PROVISIONAL

      Source sequence(s)
      BC079096
      UniProtKB/Swiss-Prot
      Q6AYD2
      Conserved Domains (2) summary
      cd04483
      Location:65165
      hOBFC1_like; hOBFC1_like: A subfamily of OB folds similar to that found in human OB fold containing protein 1 (hOBFC1). Members of this group belong to the Replication protein A subunit 2 (RPA2) family of OB folds. RPA is a nuclear ssDNA binding protein (SSB) which ...
      pfam09170
      Location:167374
      STN1_2; CST, Suppressor of cdc thirteen homolog, complex subunit STN1

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      256336916..256371143 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017589043.3XP_017444532.1  CST complex subunit STN1 isoform X1

      UniProtKB/TrEMBL
      A0A0H2UHR9, A0A8I6A2S8, A6JHQ6
      Conserved Domains (2) summary
      cd04483
      Location:65165
      hOBFC1_like; A subfamily of OB folds similar to that found in human OB fold containing protein 1 (hOBFC1). Members of this group belong to the Replication protein A subunit 2 (RPA2) family of OB folds. RPA is a nuclear ssDNA binding protein (SSB) which appears to be ...
      pfam09170
      Location:167340
      STN1_2; CST, Suppressor of cdc thirteen homolog, complex subunit STN1
    2. XM_006231474.5XP_006231536.1  CST complex subunit STN1 isoform X2

      UniProtKB/TrEMBL
      A0A8I6A2S8
      Conserved Domains (2) summary
      cd04483
      Location:65165
      hOBFC1_like; hOBFC1_like: A subfamily of OB folds similar to that found in human OB fold containing protein 1 (hOBFC1). Members of this group belong to the Replication protein A subunit 2 (RPA2) family of OB folds. RPA is a nuclear ssDNA binding protein (SSB) which ...
      pfam09170
      Location:167342
      STN1_2; CST, Suppressor of cdc thirteen homolog, complex subunit STN1
    3. XM_039109088.2XP_038965016.1  CST complex subunit STN1 isoform X1

      UniProtKB/TrEMBL
      A0A0H2UHR9, A0A8I6A2S8, A6JHQ6
      Conserved Domains (2) summary
      cd04483
      Location:65165
      hOBFC1_like; A subfamily of OB folds similar to that found in human OB fold containing protein 1 (hOBFC1). Members of this group belong to the Replication protein A subunit 2 (RPA2) family of OB folds. RPA is a nuclear ssDNA binding protein (SSB) which appears to be ...
      pfam09170
      Location:167340
      STN1_2; CST, Suppressor of cdc thirteen homolog, complex subunit STN1
    4. XM_006231472.4XP_006231534.1  CST complex subunit STN1 isoform X1

      See identical proteins and their annotated locations for XP_006231534.1

      UniProtKB/TrEMBL
      A0A0H2UHR9, A0A8I6A2S8, A6JHQ6
      Related
      ENSRNOP00000101153.1, ENSRNOT00000130024.1
      Conserved Domains (2) summary
      cd04483
      Location:65165
      hOBFC1_like; A subfamily of OB folds similar to that found in human OB fold containing protein 1 (hOBFC1). Members of this group belong to the Replication protein A subunit 2 (RPA2) family of OB folds. RPA is a nuclear ssDNA binding protein (SSB) which appears to be ...
      pfam09170
      Location:167340
      STN1_2; CST, Suppressor of cdc thirteen homolog, complex subunit STN1
    5. XM_006231475.5XP_006231537.1  CST complex subunit STN1 isoform X3

      Conserved Domains (2) summary
      pfam09170
      Location:130306
      STN1_2; CST, Suppressor of cdc thirteen homolog, complex subunit STN1
      cl09930
      Location:44128
      RPA_2b-aaRSs_OBF_like; Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold.
    6. XM_039109099.2XP_038965027.1  CST complex subunit STN1 isoform X4

      Conserved Domains (2) summary
      cd04483
      Location:65165
      hOBFC1_like; A subfamily of OB folds similar to that found in human OB fold containing protein 1 (hOBFC1). Members of this group belong to the Replication protein A subunit 2 (RPA2) family of OB folds. RPA is a nuclear ssDNA binding protein (SSB) which appears to be ...
      pfam09170
      Location:167203
      STN1_2; CST, Suppressor of cdc thirteen homolog, complex subunit STN1