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    Rapgef5 Rap guanine nucleotide exchange factor 5 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 362799, updated on 2-May-2024

    Summary

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    Official Symbol
    Rapgef5provided by RGD
    Official Full Name
    Rap guanine nucleotide exchange factor 5provided by RGD
    Primary source
    RGD:1561668
    See related
    Ensembl:ENSRNOG00000005271 AllianceGenome:RGD:1561668
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Mrgef; rMR-GEF; RGD1562891
    Summary
    Predicted to enable GTP-dependent protein binding activity and guanyl-nucleotide exchange factor activity. Predicted to be involved in regulation of catalytic activity and small GTPase mediated signal transduction. Predicted to be located in nuclear body. Orthologous to human RAPGEF5 (Rap guanine nucleotide exchange factor 5). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Lung (RPKM 182.1), Brain (RPKM 177.8) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Rapgef5 in Genome Data Viewer
    Location:
    6q33
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (144588162..144822908)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (138445184..138679943)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (145387890..145625243)

    Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene lactate dehydrogenase A, pseudogene 25 Neighboring gene uncharacterized LOC120093171 Neighboring gene uncharacterized LOC102556588 Neighboring gene uncharacterized LOC134479493 Neighboring gene 60S acidic ribosomal protein P2 pseudogene Neighboring gene cell division cycle associated 7 like Neighboring gene ribosomal protein L32, pseudogene 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Characterization of GFR, a novel guanine nucleotide exchange factor for Rap1. Ichiba T, et al. FEBS Lett, 1999 Aug 20. PMID 10486569
    2. Identification of guanine nucleotide exchange factors (GEFs) for the Rap1 GTPase. Regulation of MR-GEF by M-Ras-GTP interaction. Rebhun JF, et al. J Biol Chem, 2000 Nov 10. PMID 10934204
    3. Expression of the guanine nucleotide exchange factor, mr-gef, is regulated during the differentiation of specific subsets of telencephalic neurons. Bithell A, et al. Brain Res Dev Brain Res, 2003 Dec 19. PMID 14643017
    4. Voltage-gated ion channel Kv4.3 is associated with Rap guanine nucleotide exchange factors and regulates angiotensin receptor type 1 signaling to small G-protein Rap. Potapova IA, et al. FEBS J, 2007 Sep. PMID 17725712
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables GTP-dependent protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables guanyl-nucleotide exchange factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables guanyl-nucleotide exchange factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in Ras protein signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in small GTPase-mediated signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in nuclear body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    rap guanine nucleotide exchange factor 5
    Names
    M-Ras-regulated Rap GEF
    MR-GEF
    Rap guanine nucleotide exchange factor (GEF) 5
    guanine nucleotide exchange factor for Rap1-like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001047915.2 → NP_001041380.2  rap guanine nucleotide exchange factor 5 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006
      UniProtKB/Swiss-Prot
      P83900
      Related
      ENSRNOP00000087207.1, ENSRNOT00000117361.1
      Conserved Domains (2) summary
      smart00147
      Location:340 → 579
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      smart00229
      Location:67 → 199
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif

    2. NM_001395143.1 → NP_001382072.1  rap guanine nucleotide exchange factor 5 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006
      UniProtKB/TrEMBL
      A0A8I6A853, F1M888
      Related
      ENSRNOP00000087882.1, ENSRNOT00000099532.1
      Conserved Domains (3) summary
      smart00147
      Location:640 → 879
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      smart00229
      Location:368 → 499
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
      cd04437
      Location:98 → 221
      DEP_Epac; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in Epac-like proteins. Epac (exchange proteins directly activated by cAMP) proteins are GEFs (guanine-nucleotide-exchange factors) for the small GTPases, Rap1 and Rap2. They are directly regulated by ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086024.1 Reference GRCr8

      Range
      144588162..144822908
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P83900.1 GenPept UniProtKB/Swiss-Prot:P83900

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
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