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    Filip1 filamin A interacting protein 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 246776, updated on 30-Mar-2024

    Summary

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    Official Symbol
    Filip1provided by RGD
    Official Full Name
    filamin A interacting protein 1provided by RGD
    Primary source
    RGD:628597
    See related
    Ensembl:ENSRNOG00000011521 AllianceGenome:RGD:628597
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Filip
    Summary
    Predicted to be involved in modification of postsynaptic structure. Is active in glutamatergic synapse and postsynaptic actin cytoskeleton. Orthologous to human FILIP1 (filamin A interacting protein 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Muscle (RPKM 190.5), Heart (RPKM 189.5) and 7 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Filip1 in Genome Data Viewer
    Location:
    8q31
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (89641509..89836772, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (80761283..80956556, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (87257312..87453432, complement)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene protein transport protein Sec61 subunit gamma-like Neighboring gene cytochrome c oxidase subunit 7A2 Neighboring gene transmembrane protein 30A Neighboring gene uncharacterized LOC134480210 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene 5'-nucleotidase domain-containing protein 2 pseudogene Neighboring gene uncharacterized LOC134480211 Neighboring gene SUMO specific peptidase 6 Neighboring gene uncharacterized LOC134480213

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Involvement of filamin A and filamin A-interacting protein (FILIP) in controlling the start and cell shape of radially migrating cortical neurons. Sato M, et al. Anat Sci Int, 2005 Mar. PMID 15794127
    2. Filamin A-interacting protein (FILIP) regulates cortical cell migration out of the ventricular zone. Nagano T, et al. Nat Cell Biol, 2002 Jul. PMID 12055638
    3. Filamin A and FILIP (Filamin A-Interacting Protein) regulate cell polarity and motility in neocortical subventricular and intermediate zones during radial migration. Nagano T, et al. J Neurosci, 2004 Oct 27. PMID 15509752, Free PMC Article
    4. Filamin A-interacting protein (FILIP) is a region-specific modulator of myosin 2b and controls spine morphology and NMDA receptor accumulation. Yagi H, et al. Sci Rep, 2014 Sep 15. PMID 25220605, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Results suggest that the amount of Filamin A helps migrating neurons determine their mode of migration, multipolar or bipolar, before entering the cortical plate and that FILIP is responsible, at least in part, for Filamin A content.
      Title: Filamin A and FILIP (Filamin A-Interacting Protein) regulate cell polarity and motility in neocortical subventricular and intermediate zones during radial migration.
    2. FILIP interacts with Filamin A, an indispensable actin-binding protein that is required for cell motility (filamin A)
      Title: Filamin A-interacting protein (FILIP) regulates cortical cell migration out of the ventricular zone.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in modification of postsynaptic structure IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in modification of postsynaptic structure ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in actin cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in actin cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in actin cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in glutamatergic synapse IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in glutamatergic synapse IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    is_active_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in postsynapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in postsynapse IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    is_active_in postsynaptic actin cytoskeleton IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in postsynaptic actin cytoskeleton IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    located_in stress fiber IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    filamin-A-interacting protein 1
    Names
    filamin-interacting protein L-Filip
    filamin-interacting protein S-Filip

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_145682.2 → NP_663715.2  filamin-A-interacting protein 1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/Swiss-Prot
      Q8JZS5, Q8K4T4
      UniProtKB/TrEMBL
      A6I1M6
      Related
      ENSRNOP00000015365.7, ENSRNOT00000015365.9
      Conserved Domains (3) summary
      PRK03918
      Location:204 → 745
      PRK03918; DNA double-strand break repair ATPase Rad50
      pfam05109
      Location:913 → 1177
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      pfam09727
      Location:73 → 255
      CortBP2; Cortactin-binding protein-2

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      89641509..89836772 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017595471.3 → XP_017450960.3  filamin-A-interacting protein 1 isoform X4

    2. XM_017595472.3 → XP_017450961.3  filamin-A-interacting protein 1 isoform X5

    3. XM_017595467.3 → XP_017450956.1  filamin-A-interacting protein 1 isoform X2

      UniProtKB/Swiss-Prot
      Q8JZS5, Q8K4T4

    4. XM_017595468.3 → XP_017450957.1  filamin-A-interacting protein 1 isoform X3

      UniProtKB/Swiss-Prot
      Q8JZS5, Q8K4T4
      UniProtKB/TrEMBL
      A6I1M6
      Conserved Domains (3) summary
      PRK03918
      Location:204 → 745
      PRK03918; DNA double-strand break repair ATPase Rad50
      pfam05109
      Location:913 → 1177
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      pfam09727
      Location:73 → 255
      CortBP2; Cortactin-binding protein-2

    5. XM_017595469.3 → XP_017450958.1  filamin-A-interacting protein 1 isoform X3

      UniProtKB/Swiss-Prot
      Q8JZS5, Q8K4T4
      UniProtKB/TrEMBL
      A6I1M6
      Conserved Domains (3) summary
      PRK03918
      Location:204 → 745
      PRK03918; DNA double-strand break repair ATPase Rad50
      pfam05109
      Location:913 → 1177
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      pfam09727
      Location:73 → 255
      CortBP2; Cortactin-binding protein-2

    6. XM_063264922.1 → XP_063120992.1  filamin-A-interacting protein 1 isoform X1

    7. XM_017595474.3 → XP_017450963.1  filamin-A-interacting protein 1 isoform X6

      UniProtKB/TrEMBL
      F1LM79
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8K4T4.1 GenPept UniProtKB/Swiss-Prot:Q8K4T4

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