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    Carmil1 capping protein regulator and myosin 1 linker 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 306941, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Carmil1provided by RGD
    Official Full Name
    capping protein regulator and myosin 1 linker 1provided by RGD
    Primary source
    RGD:1306623
    See related
    EnsemblRapid:ENSRNOG00000016576 AllianceGenome:RGD:1306623
    Gene type
    protein coding
    RefSeq status
    INFERRED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Lrrc16; Lrrc16a
    Summary
    Predicted to be involved in several processes, including actin filament network formation; plasma membrane bounded cell projection organization; and regulation of actin filament organization. Predicted to be located in several cellular components, including cell leading edge; macropinosome; and nuclear speck. Predicted to be part of filamentous actin. Predicted to be active in lamellipodium and plasma membrane. Orthologous to human CARMIL1 (capping protein regulator and myosin 1 linker 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Testes (RPKM 137.4), Adrenal (RPKM 135.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Carmil1 in Genome Data Viewer
    Location:
    17p11
    Exon count:
    42
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 17 NC_086035.1 (41235819..41516204)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (40807921..41088326)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (43050282..43339403)

    Chromosome 17 - NC_086035.1Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORA17 Neighboring gene adaptor related protein complex 1 subunit beta 1, pseudogene 1 Neighboring gene small ubiquitin-like modifier 1, pseudogene 1 Neighboring gene uncharacterized LOC120097824 Neighboring gene uncharacterized LOC120097823 Neighboring gene uncharacterized LOC100909739 Neighboring gene secretagogin, EF-hand calcium binding protein Neighboring gene H2A clustered histone 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Common variant of leucine-rich repeat-containing 16A (LRRC16A) gene is associated with gout susceptibility. Sakiyama M, et al. Hum Cell, 2014 Jan. PMID 24318514, Free PMC Article
    2. Cell Migration and Invadopodia Formation Require a Membrane-binding Domain of CARMIL2. Lanier MH, et al. J Biol Chem, 2016 Jan 15. PMID 26578515, Free PMC Article
    3. Distinct roles for CARMIL isoforms in cell migration. Liang Y, et al. Mol Biol Cell, 2009 Dec. PMID 19846667, Free PMC Article
    4. Mammalian CARMIL inhibits actin filament capping by capping protein. Yang C, et al. Dev Cell, 2005 Aug. PMID 16054028, Free PMC Article
    5. Meta-analysis of 28,141 individuals identifies common variants within five new loci that influence uric acid concentrations. Kolz M, et al. PLoS Genet, 2009 Jun. PMID 19503597, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in actin filament network formation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in barbed-end actin filament uncapping ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in lamellipodium assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in macropinocytosis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of barbed-end actin filament capping ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of actin filament polymerization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of cell migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of lamellipodium organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of stress fiber assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of substrate adhesion-dependent cell spreading ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of Arp2/3 complex-mediated actin nucleation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ruffle organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in urate metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cell leading edge ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of filamentous actin ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in lamellipodium IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in lamellipodium ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in macropinosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear speck IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear speck ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    F-actin-uncapping protein LRRC16A
    Names
    leucine rich repeat containing 16
    leucine rich repeat containing 16A
    leucine-rich repeat-containing protein 16A

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001191692.1 → NP_001178621.1  F-actin-uncapping protein LRRC16A

      Status: INFERRED

      Source sequence(s)
      JAXUCZ010000017
      UniProtKB/TrEMBL
      A0A0G2JXG7, A0A8I6AJW0
      Related
      ENSRNOP00000056268.4, ENSRNOT00000059510.5
      Conserved Domains (4) summary
      cd00116
      Location:229 → 373
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00031
      Location:248 → 275
      LRR_1; leucine-rich repeat [structural motif]
      sd00033
      Location:339 → 366
      LRR_RI; leucine-rich repeat [structural motif]
      pfam16000
      Location:790 → 1080
      CARMIL_C; CARMIL C-terminus

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086035.1 Reference GRCr8

      Range
      41235819..41516204
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063276423.1 → XP_063132493.1  F-actin-uncapping protein LRRC16A isoform X9

    2. XM_063276428.1 → XP_063132498.1  F-actin-uncapping protein LRRC16A isoform X13

      Related
      ENSRNOP00000081294.2, ENSRNOT00000117749.2

    3. XM_063276429.1 → XP_063132499.1  F-actin-uncapping protein LRRC16A isoform X14

    4. XM_063276430.1 → XP_063132500.1  F-actin-uncapping protein LRRC16A isoform X14

    5. XM_063276420.1 → XP_063132490.1  F-actin-uncapping protein LRRC16A isoform X5

    6. XM_063276421.1 → XP_063132491.1  F-actin-uncapping protein LRRC16A isoform X6

    7. XM_063276431.1 → XP_063132501.1  F-actin-uncapping protein LRRC16A isoform X15

      Related
      ENSRNOP00000099065.1, ENSRNOT00000121246.1

    8. XM_008771642.4 → XP_008769864.2  F-actin-uncapping protein LRRC16A isoform X1

      UniProtKB/TrEMBL
      A0A8I6AJW0

    9. XM_063276422.1 → XP_063132492.1  F-actin-uncapping protein LRRC16A isoform X7

    10. XM_063276425.1 → XP_063132495.1  F-actin-uncapping protein LRRC16A isoform X11

    11. XM_063276426.1 → XP_063132496.1  F-actin-uncapping protein LRRC16A isoform X11

    12. XM_063276427.1 → XP_063132497.1  F-actin-uncapping protein LRRC16A isoform X11

    13. XM_063276418.1 → XP_063132488.1  F-actin-uncapping protein LRRC16A isoform X2

      Related
      ENSRNOP00000085444.2, ENSRNOT00000108358.2

    14. XM_008771644.4 → XP_008769866.2  F-actin-uncapping protein LRRC16A isoform X3

      UniProtKB/TrEMBL
      A0A8I6AJW0
      Related
      ENSRNOP00000095539.2, ENSRNOT00000104932.2

    15. XM_017600541.3 → XP_017456030.1  F-actin-uncapping protein LRRC16A isoform X8

      UniProtKB/TrEMBL
      A0A8I6AJW0
      Related
      ENSRNOP00000070264.3, ENSRNOT00000080745.3

    16. XM_039095698.2 → XP_038951626.1  F-actin-uncapping protein LRRC16A isoform X12

      UniProtKB/TrEMBL
      A0A8I6A2B1, A0A8I6G5R0
      Related
      ENSRNOP00000102732.1, ENSRNOT00000164795.1
      Conserved Domains (6) summary
      PHA02682
      Location:1128 → 1279
      PHA02682; ORF080 virion core protein; Provisional
      sd00031
      Location:248 → 275
      LRR_1; leucine-rich repeat [structural motif]
      sd00033
      Location:339 → 366
      LRR_RI; leucine-rich repeat [structural motif]
      pfam16000
      Location:786 → 1076
      CARMIL_C; CARMIL C-terminus
      pfam17888
      Location:38 → 119
      Carm_PH; Carmil pleckstrin homology domain
      cl39015
      Location:281 → 595
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

    17. XM_063276419.1 → XP_063132489.1  F-actin-uncapping protein LRRC16A isoform X4

    18. XM_063276424.1 → XP_063132494.1  F-actin-uncapping protein LRRC16A isoform X10

    Nucleotide Protein Strain
    Heading Accession and Version

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