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    Tk1 thymidine kinase 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 24834, updated on 14-Nov-2024

    Summary

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    Official Symbol
    Tk1provided by RGD
    Official Full Name
    thymidine kinase 1provided by RGD
    Primary source
    RGD:621014
    See related
    EnsemblRapid:ENSRNOG00000047314 AllianceGenome:RGD:621014
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Tk
    Summary
    Enables identical protein binding activity. Involved in several processes, including fetal process involved in parturition; response to cortisol; and thymidine metabolic process. Predicted to be located in cytoplasm and nucleus. Orthologous to human TK1 (thymidine kinase 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Spleen (RPKM 260.9), Thymus (RPKM 147.2) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Tk1 in Genome Data Viewer
    Location:
    10q32.2
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (103533449..103544818, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (103034755..103046125, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (106817556..106828888, complement)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene smilar to human chromosome 17 open reading frame 99 Neighboring gene U6 spliceosomal RNA Neighboring gene synaptogyrin 2 Neighboring gene arylformamidase Neighboring gene uncharacterized LOC102548046 Neighboring gene baculoviral IAP repeat-containing 5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Glutamate dehydrogenase, alanine aminotransferase, thymidine kinase, and arginase in fetal and adult human and rat liver. Herzfeld A, et al. Pediatr Res, 1976 Dec. PMID 995499
    2. The rat thymidine kinase gene 5' region: evolution of a promoter. Arcot SS, et al. DNA Seq, 1991. PMID 1777676
    3. Cloning vectors for expression of cDNA libraries in mammalian cells. Murphy AJ, et al. Proc Natl Acad Sci U S A, 1987 Dec. PMID 3479791, Free PMC Article
    4. Effect of copper and cadmium pretreatments on DNA synthesis and thymidine kinase activity in the liver of dimethylnitrosamine-treated and partially hepatectomized rats. Sakai K, et al. Gan, 1983 Oct. PMID 6642140
    5. HSV type 1 thymidine kinase protein accumulation in round spermatids induces male infertility by spermatogenesis disruption and apoptotic loss of germ cells. Cai LY, et al. Reprod Toxicol, 2009 Jan. PMID 19063959

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. A cytosolic form of TK2 was identified in all tested tissues in addition to mitochondrial TK2. TK1 was detected in liver and spleen cytosolic extracts while dCK was found in liver, spleen and lung cytosolic extracts.
      Title: Tissue specific distribution of pyrimidine deoxynucleoside salvage enzymes shed light on the mechanism of mitochondrial DNA depletion.
    2. These results suggest that the expression of HSV1-TK in testes brings about not only abnormal spermiogenesis but also a loss of germ cells due to apoptosis.
      Title: HSV type 1 thymidine kinase protein accumulation in round spermatids induces male infertility by spermatogenesis disruption and apoptotic loss of germ cells.
    3. Thymidine kinase 1 is a molecular target for boron neutron capture therapy of brain tumors.
      Title: Thymidine kinase 1 as a molecular target for boron neutron capture therapy of brain tumors.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables thymidine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables thymidine kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables thymidine kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables zinc ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables zinc ion binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA synthesis involved in mitotic DNA replication ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in deoxyribonucleoside monophosphate biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in digestive tract development IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in fetal process involved in parturition IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in liver development IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in protein homotetramerization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein homotetramerization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in response to copper ion IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in response to cortisol IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in response to nutrient levels IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in response to toxic substance IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in skeletal muscle cell proliferation IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in thymidine biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in thymidine metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in thymidine metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    thymidine kinase, cytosolic
    Names
    thymidine kinase 1, soluble
    NP_434687.1
    XP_017452506.1
    XP_038941153.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_052800.1 → NP_434687.1  thymidine kinase, cytosolic

      See identical proteins and their annotated locations for NP_434687.1

      Status: VALIDATED

      Source sequence(s)
      AW919734, BF547747, BP495650, CK471539, CV072953, EV770793, M22642
      UniProtKB/TrEMBL
      A6HL31, M0RCX2
      Related
      ENSRNOP00000067459.2, ENSRNOT00000071420.4
      Conserved Domains (1) summary
      cl23762
      Location:18 → 197
      TK; Thymidine kinase

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      103533449..103544818 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017597017.3 → XP_017452506.1  thymidine kinase, cytosolic isoform X1

      UniProtKB/TrEMBL
      A6HL32, M0RCX2
      Conserved Domains (1) summary
      cl23762
      Location:1 → 161
      TK; Thymidine kinase

    2. XM_039085225.2 → XP_038941153.1  thymidine kinase, cytosolic isoform X2

      Related
      ENSRNOP00000112471.1, ENSRNOT00000142849.1
      Conserved Domains (1) summary
      cl23762
      Location:18 → 70
      TK; Thymidine kinase
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P27158.1 GenPept UniProtKB/Swiss-Prot:P27158

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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