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    FEZF2 FEZ family zinc finger 2 [ Homo sapiens (human) ]

    Gene ID: 55079, updated on 12-Nov-2024

    Summary

    Official Symbol
    FEZF2provided by HGNC
    Official Full Name
    FEZ family zinc finger 2provided by HGNC
    Primary source
    HGNC:HGNC:13506
    See related
    Ensembl:ENSG00000153266 MIM:607414; AllianceGenome:HGNC:13506
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    FEZ; TOF; FEZL; FKSG36; ZFP312; ZNF312
    Summary
    Predicted to enable several functions, including DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and chromatin binding activity. Predicted to be involved in regulation of gene expression. Predicted to act upstream of or within several processes, including negative regulation of transcription by RNA polymerase II; nervous system development; and regulation of neuron differentiation. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Restricted expression toward brain (RPKM 4.1) See more
    Orthologs
    NEW
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    Genomic context

    See FEZF2 in Genome Data Viewer
    Location:
    3p14.2
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (62369681..62373550, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (62413195..62417065, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (62355356..62359225, complement)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene protein tyrosine phosphatase receptor type G Neighboring gene PTPRG antisense RNA 1 Neighboring gene Sharpr-MPRA regulatory region 9750 Neighboring gene VISTA enhancer hs434 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:62353809-62354715 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:62354716-62355621 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:62357949-62358508 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:62358509-62359066 Neighboring gene VISTA enhancer hs435 Neighboring gene uncharacterized LOC105377647 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:62362829-62363426 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:62362229-62362828 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr3:62400506-62401328 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr3:62401329-62402151 Neighboring gene VISTA enhancer hs1316 Neighboring gene centrosomal protein 15 Neighboring gene calcium dependent secretion activator Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:62523426-62524136 Neighboring gene Sharpr-MPRA regulatory region 8400 Neighboring gene Sharpr-MPRA regulatory region 14545 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20029 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20030 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:62654458-62654958 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:62654959-62655459 Neighboring gene ribosomal protein L14 pseudogene 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    Knockdown of FEZ family zinc finger 2 (FEZF2) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ10142

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    involved_in axonal fasciculation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cell dedifferentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cerebral cortex GABAergic interneuron migration IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in commitment of neuronal cell to specific neuron type in forebrain IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in dendrite development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in dentate gyrus development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in forebrain anterior/posterior pattern specification IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in locomotory behavior IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of cell population proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of neuron differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in neuron fate determination IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of neuron differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of axon guidance IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of gene expression IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of neurogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    fez family zinc finger protein 2
    Names
    forebrain embryonic zinc finger-like protein 2
    testis tissue sperm-binding protein Li 80P
    too few
    zinc finger protein 312

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_018008.4NP_060478.3  fez family zinc finger protein 2

      See identical proteins and their annotated locations for NP_060478.3

      Status: VALIDATED

      Source sequence(s)
      AC092502, BC022464, BM930804, DA492936, DR002892, H28929
      Consensus CDS
      CCDS2897.1
      UniProtKB/Swiss-Prot
      A8K349, Q8TBJ5, Q9BZ91, Q9NWB9
      UniProtKB/TrEMBL
      A0A140VKG3
      Related
      ENSP00000283268.3, ENST00000283268.8
      Conserved Domains (3) summary
      COG5048
      Location:289395
      COG5048; FOG: Zn-finger [General function prediction only]
      COG5189
      Location:385441
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      sd00017
      Location:279299
      ZF_C2H2; C2H2 Zn finger [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

      Range
      62369681..62373550 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060927.1 Alternate T2T-CHM13v2.0

      Range
      62413195..62417065 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)