Cd34 CD34 antigen [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cd34provided by MGI
Official Full Name: CD34 antigenprovided by MGI
Primary source: MGI:MGI:88329
See related: Ensembl:ENSMUSG00000016494 AllianceGenome:MGI:88329
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Enables sulfate binding activity. Acts upstream of or within leukocyte migration. Located in cytoplasm; external side of plasma membrane; and extracellular region. Is expressed in several structures, including alimentary system; cardiovascular system; extraembryonic component; genitourinary system; and liver. Orthologous to human CD34 (CD34 molecule). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in bladder adult (RPKM 83.8), subcutaneous fat pad adult (RPKM 60.4) and 21 other tissues See more
Orthologs: human all
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Genomic context

Location:: 1 H6; 1 98.38 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (194621239..194643587)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (194938821..194961292)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CD34 is Expressed in Endothelial Cells in Embryonic Testes and is Additionally Expressed in Non-Endothelial Cells in Postnatal Mouse Testes.
Title: CD34 is Expressed in Endothelial Cells in Embryonic Testes and is Additionally Expressed in Non-Endothelial Cells in Postnatal Mouse Testes.
Lack of CD34 delays bacterial endotoxin-induced lung inflammation.
Title: Lack of CD34 delays bacterial endotoxin-induced lung inflammation.
Lack of CD34 produces defects in platelets, microparticles, and lung inflammation.
Title: Lack of CD34 produces defects in platelets, microparticles, and lung inflammation.
CD34 and EPCR coordinately enrich functional murine hematopoietic stem cells under normal and inflammatory conditions.
Title: CD34 and EPCR coordinately enrich functional murine hematopoietic stem cells under normal and inflammatory conditions.
In this study, we demonstrate that CD34(+) and CD34(-) subpopulations carrying the BRAF(V600E) mutation confer differential sensitivity to targeted BRAF inhibition. Through elevated KDM5B expression, melanoma cells shift toward a more drug-tolerant, CD34(-) state upon exposure to BRAF inhibitor or combined BRAF inhibitor and MEK inhibitor treatment
Title: KDM5B Promotes Drug Resistance by Regulating Melanoma-Propagating Cell Subpopulations.
These results provide evidence that CD34 is required for AHR and airway reactivity maintenance in the early days after an inflammatory episode in asthma.
Title: CD34 Differentially Regulates Contractile and Noncontractile Elements of Airway Reactivity.
data suggest that CD34 plays an essential role in maintaining vascular integrity in the lung in response to chemical- and infection-induced tissue damage.
Title: Loss of Vascular CD34 Results in Increased Sensitivity to Lung Injury.
sca-1 antibody reduces both CD34+/c-kit+ progenitor cell surge and vascular restenosis after endoluminal vascular injury in a murine model.
Title: A depleting antibody toward sca-1 mitigates a surge of CD34(+)/c-kit(+) progenitors and reduces vascular restenosis in a murine vascular injury model.
Aging induces loss of stemness with concomitant gain of myogenic properties of a pure population of CD34+/CD45- muscle derived stem cells.
Title: Aging induced loss of stemness with concomitant gain of myogenic properties of a pure population of CD34(+)/CD45(-) muscle derived stem cells.
Stem cell factor is essential for preserving reconstitution capacity of ex vivo expanded cord blood CD34(+) cells in Immunocompromised mice.
Title: Stem cell factor is essential for preserving NOD/SCID reconstitution capacity of ex vivo expanded cord blood CD34(+) cells.

Submit: New GeneRIF Correction See all GeneRIFs (38)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (5)
Targeted (3) 1 citation

General gene information

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Markers

Cd34 (e-PCR), detects polymorphism
- UniSTS:238156

px-38e3 (e-PCR)
- UniSTS:257695

AU040960 (e-PCR)
- UniSTS:158909

Cd34 (e-PCR), detects polymorphism
- UniSTS:141276

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables RNA polymerase II-specific DNA-binding transcription factor binding	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II-specific DNA-binding transcription factor binding	ISO Inferred from Sequence Orthology more info
enables carbohydrate binding	ISO Inferred from Sequence Orthology more info
enables carbohydrate binding	ISS Inferred from Sequence or Structural Similarity more info
enables sulfate binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in cell-cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in cell-cell adhesion	ISS Inferred from Sequence or Structural Similarity more info
involved_in cell-matrix adhesion	IBA Inferred from Biological aspect of Ancestor more info
involved_in endothelial cell proliferation	IEA Inferred from Electronic Annotation more info
involved_in endothelial cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in extracellular exosome assembly	IEA Inferred from Electronic Annotation more info
involved_in extracellular exosome assembly	ISO Inferred from Sequence Orthology more info
involved_in glomerular endothelium development	IEA Inferred from Electronic Annotation more info
involved_in glomerular filtration	ISS Inferred from Sequence or Structural Similarity more info
involved_in hematopoietic stem cell proliferation	IEA Inferred from Electronic Annotation more info
involved_in hematopoietic stem cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in hemopoiesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within leukocyte migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mesangial cell-matrix adhesion	ISS Inferred from Sequence or Structural Similarity more info
involved_in metanephric glomerular mesangial cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of interleukin-2 production	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of interleukin-2 production	ISO Inferred from Sequence Orthology more info
involved_in paracrine signaling	IEA Inferred from Electronic Annotation more info
involved_in paracrine signaling	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of angiogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of granulocyte colony-stimulating factor production	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of granulocyte colony-stimulating factor production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of odontogenesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of odontogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of vasculogenesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of vasculogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in signal transduction	IEA Inferred from Electronic Annotation more info
involved_in tissue homeostasis	ISO Inferred from Sequence Orthology more info
involved_in tissue homeostasis	ISS Inferred from Sequence or Structural Similarity more info
involved_in transdifferentiation	IEA Inferred from Electronic Annotation more info
involved_in vascular wound healing	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in apical plasma membrane	ISO Inferred from Sequence Orthology more info
located_in apical plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in basal plasma membrane	ISO Inferred from Sequence Orthology more info
located_in basal plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in cell periphery	IDA Inferred from Direct Assay more info	PubMed
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in external side of plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in external side of plasma membrane	ISO Inferred from Sequence Orthology more info
located_in extracellular region	IDA Inferred from Direct Assay more info	PubMed
part_of glomerular endothelium fenestra	ISO Inferred from Sequence Orthology more info
part_of glomerular endothelium fenestra	ISS Inferred from Sequence or Structural Similarity more info
located_in intercellular bridge	ISO Inferred from Sequence Orthology more info
located_in intercellular bridge	ISS Inferred from Sequence or Structural Similarity more info
located_in lysosome	ISO Inferred from Sequence Orthology more info
located_in lysosome	ISS Inferred from Sequence or Structural Similarity more info
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: hematopoietic progenitor cell antigen CD34

Names: cluster designation 34

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.