agr2 anterior gradient 2 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: agr2provided by ZNC
Official Full Name: anterior gradient 2provided by ZNC
Primary source: ZFIN:ZDB-GENE-050417-214
See related: Ensembl:ENSDARG00000070480 AllianceGenome:ZFIN:ZDB-GENE-050417-214
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: sb:eu228; wu:fj29g05; zgc:112187
Summary: Predicted to enable identical protein binding activity. Acts upstream of or within intestinal epithelial cell differentiation. Predicted to be located in extracellular region. Predicted to be active in endoplasmic reticulum. Is expressed in several structures, including digestive system; hatching gland; integument; olfactory system; and vestibuloauditory system. Orthologous to several human genes including AGR2 (anterior gradient 2, protein disulphide isomerase family member). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 19

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	19	NC_007130.7 (30401547..30404099, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	19	NC_007130.6 (30814234..30816786, complement)

Chromosome 19 - NC_007130.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Delta/Jagged-mediated Notch signaling induces the differentiation of agr2-positive epidermal mucous cells in zebrafish embryos.
Title: Delta/Jagged-mediated Notch signaling induces the differentiation of agr2-positive epidermal mucous cells in zebrafish embryos.
Agr2 is essential for terminal differentiation of intestinal goblet cells in zebrafish embryos
Title: Zebrafish Agr2 is required for terminal differentiation of intestinal goblet cells.
Both phylogenetic and syntenic analyses indicate that zebrafish agr2 is the orthologue of human AGR2 and mouse Agr2 genes.
Title: Characterization of the agr2 gene, a homologue of X. laevis anterior gradient 2, from the zebrafish, Danio rerio.

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables identical protein binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within intestinal epithelial cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cell-substrate adhesion	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in extracellular region	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: anterior gradient protein 2 homolog

Names: anterior gradient homolog 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001012481.2 → NP_001012499.1 anterior gradient protein 2 homolog precursor

See identical proteins and their annotated locations for NP_001012499.1

Status: VALIDATED

Source sequence(s)

BE557539, EB797007, EH453285

UniProtKB/Swiss-Prot

A7MCE1, Q5RZ65

Related

ENSDARP00000094251.4, ENSDART00000103475.5

Conserved Domains (1) summary

cd02960
Location:42 → 171

AGR; Anterior Gradient (AGR) family; members of this family are similar to secreted proteins encoded by the cement gland-specific genes XAG-1 and XAG-2, expressed in the anterior region of dorsal ectoderm of Xenopus. They are implicated in the formation of ...