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    ldha lactate dehydrogenase A4 [ Danio rerio (zebrafish) ]

    Gene ID: 30496, updated on 12-May-2024

    Summary

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    Official Symbol
    ldhaprovided by ZNC
    Official Full Name
    lactate dehydrogenase A4provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-991026-5
    See related
    Ensembl:ENSDARG00000101251 AllianceGenome:ZFIN:ZDB-GENE-991026-5
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Summary
    Predicted to enable L-lactate dehydrogenase activity. Acts upstream of or within response to hypoxia. Predicted to be located in cytoplasm. Is expressed in several structures, including cardiovascular system; gill; liver; muscle; and nervous system. Orthologous to several human genes including LDHA (lactate dehydrogenase A). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See ldha in Genome Data Viewer
    Location:
    chromosome: 25
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    106 current GRCz11 (GCF_000002035.6) 25 NC_007136.7 (25123385..25131749)
    105 previous assembly GRCz10 (GCF_000002035.5) 25 NC_007136.6 (25028201..25036565)

    Chromosome 25 - NC_007136.7Genomic Context describing neighboring genes Neighboring gene si:ch73-182e20.4 Neighboring gene chymotrypsin-like protease CTRL-1 Neighboring gene tumor susceptibility 101a Neighboring gene transfer RNA isoleucine (anticodon AAU)

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Targeting lactate dehydrogenase A (LDHA) exerts antileukemic effects on T-cell acute lymphoblastic leukemia. Yu H, et al. Cancer Commun (Lond), 2020 Oct. PMID 32820611, Free PMC Article
    2. Hypoxia as a therapy for mitochondrial disease. Jain IH, et al. Science, 2016 Apr 1. PMID 26917594, Free PMC Article
    3. Phylogenetic analysis of vertebrate lactate dehydrogenase (LDH) multigene families. Li YJ, et al. J Mol Evol, 2002 May. PMID 11965434
    4. The serine-threonine kinase LKB1 is essential for survival under energetic stress in zebrafish. van der Velden YU, et al. Proc Natl Acad Sci U S A, 2011 Mar 15. PMID 21368212, Free PMC Article
    5. Lactate metabolism coordinates macrophage response and regeneration in zebrafish. Bohaud C, et al. Theranostics, 2022. PMID 35664055, Free PMC Article

    See all (60) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables L-lactate dehydrogenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables L-lactate dehydrogenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables catalytic activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within carboxylic acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in lactate metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in pyruvate metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within response to hypoxia IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    L-lactate dehydrogenase A chain
    Names
    LDH-A
    ldha1
    NP_571321.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_131246.1 → NP_571321.1  L-lactate dehydrogenase A chain

      See identical proteins and their annotated locations for NP_571321.1

      Status: PROVISIONAL

      Source sequence(s)
      AF067201
      UniProtKB/Swiss-Prot
      Q9PVK5
      Related
      ENSDARP00000137433.1, ENSDART00000163892.2
      Conserved Domains (2) summary
      cd05293
      Location:19 → 330
      LDH_1; A subgroup of L-lactate dehydrogenases
      TIGR01771
      Location:39 → 325
      L-LDH-NAD; L-lactate dehydrogenase

    RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007136.7 Reference GRCz11 Primary Assembly

      Range
      25123385..25131749
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9PVK5.3 GenPept UniProtKB/Swiss-Prot:Q9PVK5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.