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    TAS2R40 taste 2 receptor member 40 [ Homo sapiens (human) ]

    Gene ID: 259286, updated on 2-Nov-2024

    Summary

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    Official Symbol
    TAS2R40provided by HGNC
    Official Full Name
    taste 2 receptor member 40provided by HGNC
    Primary source
    HGNC:HGNC:18885
    See related
    Ensembl:ENSG00000221937 MIM:613964; AllianceGenome:HGNC:18885
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    GPR60; T2R40; T2R58
    Summary
    This gene encodes a member of the bitter taste receptor family which belong to the G protein-coupled receptor superfamily and are predominantly expressed in taste receptor cells of the tongue and palate epithelia. This intronless taste receptor gene encodes a seven-transmembrane receptor protein, functioning as a bitter taste receptor. This gene is clustered together with eight other taste receptor genes on chromosome 7. A decrease in the expression of this gene is associated with hypogeusia. [provided by RefSeq, Jul 2017]
    Orthologs
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    Genomic context

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    See TAS2R40 in Genome Data Viewer
    Location:
    7q34
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (143222037..143223079)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (144577457..144578499)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (142919130..142920172)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene taste 2 receptor member 39 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26790 Neighboring gene uncharacterized LOC124901764 Neighboring gene uncharacterized LOC105375546 Neighboring gene ReSE screen-validated silencer GRCh37_chr7:142943994-142944170 Neighboring gene TMEM139 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18719 Neighboring gene Sharpr-MPRA regulatory region 7901 Neighboring gene glutathione S-transferase kappa 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Patients with hypogeusia show changes in expression of T2R taste receptor genes in their tongues. Onoda K, et al. Laryngoscope, 2011 Dec. PMID 22109758
    2. Major haplotypes of the human bitter taste receptor TAS2R41 encode functional receptors for chloramphenicol. Thalmann S, et al. Biochem Biophys Res Commun, 2013 May 31. PMID 23632330
    3. Identification and characterization of human taste receptor genes belonging to the TAS2R family. Conte C, et al. Cytogenet Genome Res, 2002. PMID 12584440
    4. The human TAS2R16 receptor mediates bitter taste in response to beta-glucopyranosides. Bufe B, et al. Nat Genet, 2002 Nov. PMID 12379855
    5. Lineage-specific loss of function of bitter taste receptor genes in humans and nonhuman primates. Go Y, et al. Genetics, 2005 May. PMID 15744053, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    Vif vif HIV-1 Vif downregulates the expression of taste receptor, type 2, member 40 (TAS2R40) in Vif-expression T cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC126844, MGC126846

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables bitter taste receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables bitter taste receptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in detection of chemical stimulus involved in sensory perception of bitter taste IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in detection of chemical stimulus involved in sensory perception of bitter taste IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IC
    Inferred by Curator
    more info
    		 PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		  

    General protein information

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    Preferred Names
    taste receptor type 2 member 40
    Names
    G-protein coupled receptor 60
    taste receptor type 2 member 58
    taste receptor, type 2, member 40

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_176882.2 → NP_795363.1  taste receptor type 2 member 40

      See identical proteins and their annotated locations for NP_795363.1

      Status: REVIEWED

      Source sequence(s)
      BC101795
      Consensus CDS
      CCDS43662.1
      UniProtKB/Swiss-Prot
      A4D2I2, P59535, Q645W6
      UniProtKB/TrEMBL
      Q50KK6
      Related
      ENSP00000386210.3, ENST00000408947.4
      Conserved Domains (1) summary
      cd15014
      Location:19 → 308
      7tm_TAS2R40; mammalian taste receptor 2, subtype 40, member of the seven-transmembraneG-protein coupled receptor superfamily

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

      Range
      143222037..143223079
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060931.1 Alternate T2T-CHM13v2.0

      Range
      144577457..144578499
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P59535.1 GenPept UniProtKB/Swiss-Prot:P59535

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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