TLN2 talin 2 [Homo sapiens (human)] - Gene

Summary

Official Symbol: TLN2provided by HGNC
Official Full Name: talin 2provided by HGNC
Primary source: HGNC:HGNC:15447
See related: Ensembl:ENSG00000171914 MIM:607349; AllianceGenome:HGNC:15447
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: ILWEQ
Summary: This gene encodes a protein related to talin 1, a cytoskeletal protein that plays a significant role in the assembly of actin filaments and in spreading and migration of various cell types, including fibroblasts and osteoclasts. This protein has a different pattern of expression compared to talin 1 but, like talin 1, is thought to associate with unique transmembrane receptors to form novel linkages between extracellular matrices and the actin cytoskeleton. [provided by RefSeq, Jul 2008]
Expression: Broad expression in kidney (RPKM 12.9), brain (RPKM 11.8) and 19 other tissues See more
Orthologs: mouse all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 15q22.2

Exon count:: 59

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	15	NC_000015.10 (62390550..62844631)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	15	NC_060939.1 (60194145..60648431)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	15	NC_000015.9 (62682749..63136830)

Chromosome 15 - NC_000015.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Talin2 and KANK2 functionally interact to regulate microtubule dynamics, paclitaxel sensitivity and cell migration in the MDA-MB-435S melanoma cell line.
Title: Talin2 and KANK2 functionally interact to regulate microtubule dynamics, paclitaxel sensitivity and cell migration in the MDA-MB-435S melanoma cell line.
[Expression of miR-4324 and its targeted gene Talin2 in breast cancer].
Title: [Expression of miR-4324 and its targeted gene Talin2 in breast cancer].
Phosphoinositides regulate force-independent interactions between talin, vinculin, and actin.
Title: Phosphoinositides regulate force-independent interactions between talin, vinculin, and actin.
A distinct talin2 structure directs isoform specificity in cell adhesion.
Title: A distinct talin2 structure directs isoform specificity in cell adhesion.
Talin2 mediates secretion and trafficking of matrix metallopeptidase 9 during invadopodium formation.
Title: Talin2 mediates secretion and trafficking of matrix metallopeptidase 9 during invadopodium formation.
Epistasis between variants of WWC1 and TLN2 in association to Alzheimer's.
Title: Male-specific epistasis between WWC1 and TLN2 genes is associated with Alzheimer's disease.
The central role of talin and vinculin in cell adhesions suggests that the disintegration of the tissue in atherosclerosis could be partially driven by downregulation of these genes, leading to loosening of cell-ECM interactions and remodeling of the tissue.
Title: Talin and vinculin are downregulated in atherosclerotic plaque; Tampere Vascular Study.
These results suggest that a strong interaction of talin2 with integrins is required to generate traction, which in turn drives invadopodium-mediated matrix degradation, which is key to cancer cell invasion.
Title: Talin2-mediated traction force drives matrix degradation and cell invasion.
data suggest a potential molecular link between TLN2 and camptodactyly pathogenesis.
Title: Exome Sequencing of a Pedigree Reveals S339L Mutation in the TLN2 Gene as a Cause of Fifth Finger Camptodactyly.
Both TLN-1 and TLN-2 levels correlate with tumorigenicity in human HCC, indicating that these molecules constitute important molecular targets for the diagnosis and/or treatment of hepatocellular carcinoma .
Title: Both Talin-1 and Talin-2 correlate with malignancy potential of the human hepatocellular carcinoma MHCC-97 L cell.

Submit: New GeneRIF Correction See all GeneRIFs (21)

Phenotypes

Go to the top of the page Help

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
A genome-wide association study of sleep habits and insomnia. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide analysis reveals novel genes influencing temporal lobe structure with relevance to neurodegeneration in Alzheimer's disease. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

Go to the top of the page Help

Protein interactions

Protein	Gene	Interaction	Pubs
matrix	gag	HIV-1 MA co-localizes with beta2 integrin, alphaM and alphaX integrins in the intracellular thick electron-dense membrane compartments, which contain talin, vinculin and paxillin that connect the integrin complexes to the actin cytoskeleton	PubMed
retropepsin	gag-pol	A number of focal adhesion plaque proteins are specifically cleaved by HIV-1 protease, including fimbrin, focal adhesion plaque kinase (FAK), talin, and, to a lesser extent, filamin, spectrin and fibronectin	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Markers

D15S635E (e-PCR)
- UniSTS:45833

D15S721E (e-PCR)
- UniSTS:151618

D15S724E (e-PCR)
- UniSTS:151619

STS-R99089 (e-PCR)
- UniSTS:37962

RH47491 (e-PCR)
- UniSTS:17504

A002V12 (e-PCR)
- UniSTS:20329

G19684 (e-PCR)
- UniSTS:61039

A001V22 (e-PCR)
- UniSTS:61040

WI-18550 (e-PCR)
- UniSTS:44996

SHGC-153677 (e-PCR)
- UniSTS:177877

RH66673 (e-PCR)
- UniSTS:7899

TLN2__5270 (e-PCR)
- UniSTS:463324

RH78027 (e-PCR)
- UniSTS:55004

Clone Names

KIAA0320, DKFZp451B1011, DKFZp686I0976, DKFZp686K0979

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables actin binding	NAS Non-traceable Author Statement more info	PubMed
enables actin filament binding	IEA Inferred from Electronic Annotation more info
enables integrin binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables structural constituent of cytoskeleton	IEA Inferred from Electronic Annotation more info
enables structural molecule activity	NAS Non-traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in actin cytoskeleton organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell adhesion	NAS Non-traceable Author Statement more info	PubMed
involved_in cell-cell adhesion	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell-cell junction assembly	TAS Traceable Author Statement more info	PubMed
involved_in presynaptic actin cytoskeleton organization	IDA Inferred from Direct Assay more info	PubMed
involved_in presynaptic actin cytoskeleton organization	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in actin cytoskeleton	NAS Non-traceable Author Statement more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in focal adhesion	HDA more info	PubMed
is_active_in focal adhesion	IBA Inferred from Biological aspect of Ancestor more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in presynapse	IEA Inferred from Electronic Annotation more info
located_in ruffle	IEA Inferred from Electronic Annotation more info
located_in synapse	NAS Non-traceable Author Statement more info	PubMed

General protein information

Go to the top of the page Help

Preferred Names: talin-2

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_033932.2 RefSeqGene

Range

5002..459083

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001394547.1 → NP_001381476.1 talin-2

Status: REVIEWED

Source sequence(s)

AC011927, AC032011, AC068233, AC100839, AC103740

Consensus CDS

CCDS32261.1

UniProtKB/Swiss-Prot

A6NLB8, Q9Y4G6

Related

ENSP00000453508.1, ENST00000561311.5

Conserved Domains (9) summary

cd12150
Location:1656 → 1827

talin-RS; rod-segment of the talin C-terminal domain

smart00307
Location:2337 → 2532

ILWEQ; I/LWEQ domain

cd10569
Location:312 → 403

FERM_C_Talin; FERM domain C-lobe/F3 of Talin

pfam08913
Location:1850 → 1974

VBS; Vinculin Binding Site

cd17172
Location:4 → 87

FERM_F0_TLN2; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F0 sub-domain, found in Talin-2 (TLN2)

cd17174
Location:88 → 199

FERM_F1_TLN2; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F1 sub-domain, found in Talin-2 (TLN2)

pfam00373
Location:209 → 316

FERM_M; FERM central domain

pfam09141
Location:494 → 655

Talin_middle; Talin, middle domain

cl19756
Location:689 → 765

I_LWEQ; I/LWEQ domain
NM_015059.3 → NP_055874.2 talin-2

See identical proteins and their annotated locations for NP_055874.2

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 both encode the same protein.

Source sequence(s)

AC011927, AC032011, AC068233, AC100839, AC103740

Consensus CDS

CCDS32261.1

UniProtKB/Swiss-Prot

A6NLB8, Q9Y4G6

Related

ENSP00000490662.2, ENST00000636159.2

Conserved Domains (9) summary

cd12150
Location:1656 → 1827

talin-RS; rod-segment of the talin C-terminal domain

smart00307
Location:2337 → 2532

ILWEQ; I/LWEQ domain

cd10569
Location:312 → 403

FERM_C_Talin; FERM domain C-lobe/F3 of Talin

pfam08913
Location:1850 → 1974

VBS; Vinculin Binding Site

cd17172
Location:4 → 87

FERM_F0_TLN2; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F0 sub-domain, found in Talin-2 (TLN2)

cd17174
Location:88 → 199

FERM_F1_TLN2; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F1 sub-domain, found in Talin-2 (TLN2)

pfam00373
Location:209 → 316

FERM_M; FERM central domain

pfam09141
Location:494 → 655

Talin_middle; Talin, middle domain

cl19756
Location:689 → 765

I_LWEQ; I/LWEQ domain