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    CDC27 cell division cycle 27 [ Homo sapiens (human) ]

    Gene ID: 996, updated on 28-Oct-2024

    Summary

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    Official Symbol
    CDC27provided by HGNC
    Official Full Name
    cell division cycle 27provided by HGNC
    Primary source
    HGNC:HGNC:1728
    See related
    Ensembl:ENSG00000004897 MIM:116946; AllianceGenome:HGNC:1728
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    APC3; HNUC; NUC2; H-NUC; ANAPC3; CDC27Hs; D0S1430E; D17S978E
    Summary
    The protein encoded by this gene shares strong similarity with Saccharomyces cerevisiae protein Cdc27, and the gene product of Schizosaccharomyces pombe nuc 2. This protein is a component of the anaphase-promoting complex (APC), which is composed of eight protein subunits and is highly conserved in eukaryotic cells. This complex catalyzes the formation of cyclin B-ubiquitin conjugate, which is responsible for the ubiquitin-mediated proteolysis of B-type cyclins. The protein encoded by this gene and three other members of the APC complex contain tetratricopeptide (TPR) repeats, which are important for protein-protein interactions. This protein was shown to interact with mitotic checkpoint proteins including Mad2, p55CDC and BUBR1, and it may thus be involved in controlling the timing of mitosis. Alternative splicing of this gene results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 2, 22 and Y. [provided by RefSeq, May 2014]
    Expression
    Ubiquitous expression in thyroid (RPKM 20.3), testis (RPKM 11.6) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See CDC27 in Genome Data Viewer
    Location:
    17q21.32
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (47117703..47189295, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (47979197..48051640, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (45195069..45266661, complement)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene leucine rich repeat containing 37 member A2 Neighboring gene uncharacterized LOC101927060 Neighboring gene leucine rich repeat containing 37 member A17, pseudogene Neighboring gene MPRA-validated peak2870 silencer Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:45145515-45146016 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:45146017-45146516 Neighboring gene uncharacterized LOC124904015 Neighboring gene RNA, 7SL, cytoplasmic 270, pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:45175453-45176078 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8621 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr17:45197166-45197776 Neighboring gene protein GVQW1-like Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr17:45213296-45214495 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:45266269-45266865 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8622 Neighboring gene CRISPRi-validated cis-regulatory element chr17.3215 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12300 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12301 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12302 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12303 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12304 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8623 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr17:45298098-45298754 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:45298755-45299410 Neighboring gene ribosomal protein S2 pseudogene 47 Neighboring gene Sharpr-MPRA regulatory region 4457 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12305 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:45314666-45315602 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:45315603-45316539 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8624 Neighboring gene myosin light chain 4 Neighboring gene RNA, U7 small nuclear 186 pseudogene Neighboring gene integrin subunit beta 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. The dephosphorylated form of the anaphase-promoting complex protein Cdc27/Apc3 concentrates on kinetochores and chromosome arms in mitosis. Topper LM, et al. Cell Cycle, 2002 Jul-Aug. PMID 12429948
    2. CDC27 Facilitates Gastric Cancer Cell Proliferation, Invasion and Metastasis via Twist-Induced Epithelial-Mesenchymal Transition. Xin Y, et al. Cell Physiol Biochem, 2018. PMID 30308498
    3. A Novel Gene CDC27 Causes SLE and Is Associated With the Disease Activity. Shang S, et al. Front Immunol, 2022. PMID 35418986, Free PMC Article
    4. Localization of the human homolog of the yeast cell division control 27 gene (CDC27) proximal to ITGB3 on human chromosome 17q21.3. Ho PP, et al. Somat Cell Mol Genet, 1995 Sep. PMID 8619132
    5. Phosphorylation of the anaphase-promoting complex/Cdc27 is involved in TGF-beta signaling. Zhang L, et al. J Biol Chem, 2011 Mar 25. PMID 21209074, Free PMC Article

    See all (296) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Functional and Genetic Analyses Unveil the Implication of CDC27 in Hemifacial Microsomia.
      Title: Functional and Genetic Analyses Unveil the Implication of CDC27 in Hemifacial Microsomia.
    2. Circ_0000775 promotes the migration, invasion and EMT of hepatic carcinoma cells by recruiting IGF2BP2 to stabilize CDC27.
      Title: Circ_0000775 promotes the migration, invasion and EMT of hepatic carcinoma cells by recruiting IGF2BP2 to stabilize CDC27.
    3. A Novel Gene CDC27 Causes SLE and Is Associated With the Disease Activity.
      Title: A Novel Gene CDC27 Causes SLE and Is Associated With the Disease Activity.
    4. Hsa_circ_0044226 knockdown attenuates progression of pulmonary fibrosis by inhibiting CDC27.
      Title: Hsa_circ_0044226 knockdown attenuates progression of pulmonary fibrosis by inhibiting CDC27.
    5. CDC27 facilitated cells invasion and metastasis via Twist pathway, leading to initiation of epithelial-mesenchymal transition and silencing of Twist expression could reverse this process.
      Title: CDC27 Facilitates Gastric Cancer Cell Proliferation, Invasion and Metastasis via Twist-Induced Epithelial-Mesenchymal Transition.
    6. mir-218-2 promotes glioblastomas growth, invasion and drug resistance by targeting CDC27 expression.
      Title: mir-218-2 promotes glioblastomas growth, invasion and drug resistance by targeting CDC27.
    7. The levels of CDC20 and CylinB1 increased and the levels of Ku70 and APC3 decreased after irradiation. APC/C(Cdh1) is involved in regulation of radiosensitivity in human NPC CNE-1 cells.
      Title: Inhibition of Anaphase-Promoting Complex by Silence APC/C(Cdh1) to Enhance Radiosensitivity of Nasopharyngeal Carcinoma Cells.
    8. Data indicate that UBE2S and APC3 co-regulate the expression level of P21 at G2/M check point via the ubiquitin-proteasome system.
      Title: UBE2S associated with OSCC proliferation by promotion of P21 degradation via the ubiquitin-proteasome system.
    9. Cdc27 is a novel binding partner of Elmo1.Cdc27-Elmo1 has a cellular role independent from the Elmo-Dock1-Rac signal module.
      Title: Identification of a novel protein interaction between Elmo1 and Cdc27.
    10. miR-27a could modulate proliferation and radiosensitivity of TNBC cells. CDC-27 is a direct target of miR-27a and its downregulation conferred increased radioresistance of the cells.
      Title: MiR-27a modulates radiosensitivity of triple-negative breast cancer (TNBC) cells by targeting CDC27.
    Submit: New GeneRIF Correction See all GeneRIFs (22)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein phosphatase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in anaphase-promoting complex-dependent catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in anaphase-promoting complex-dependent catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in anaphase-promoting complex-dependent catabolic process NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in cell division IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in metaphase/anaphase transition of mitotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within metaphase/anaphase transition of mitotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein K11-linked ubiquitination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein K48-linked ubiquitination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein branched polyubiquitination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of meiotic cell cycle NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of mitotic cell cycle NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of anaphase-promoting complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of anaphase-promoting complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of anaphase-promoting complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    part_of anaphase-promoting complex NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in centrosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		  
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    located_in mitotic spindle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in spindle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    cell division cycle protein 27 homolog
    Names
    D0S1430E, D17S978E
    anaphase promoting complex subunit 3
    anaphase-promoting complex, protein 3
    cell division cycle 27 homolog
    nuc2 homolog

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001114091.4 → NP_001107563.1  cell division cycle protein 27 homolog isoform 1

      See identical proteins and their annotated locations for NP_001107563.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AA927469, AC002558, BC011656, HY023336
      Consensus CDS
      CCDS45720.1
      UniProtKB/Swiss-Prot
      P30260
      Related
      ENSP00000434614.1, ENST00000531206.5
      Conserved Domains (5) summary
      COG0457
      Location:507 → 768
      TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
      sd00006
      Location:573 → 601
      TPR; TPR repeat [structural motif]
      pfam00515
      Location:641 → 673
      TPR_1; Tetratricopeptide repeat
      pfam12895
      Location:17 → 92
      ANAPC3; Anaphase-promoting complex, cyclosome, subunit 3
      pfam13424
      Location:463 → 534
      TPR_12; Tetratricopeptide repeat

    2. NM_001256.6 → NP_001247.3  cell division cycle protein 27 homolog isoform 2

      See identical proteins and their annotated locations for NP_001247.3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the central coding region, compared to variant 1, resulting in an isoform (2) that is shorter than isoform 1.
      Source sequence(s)
      AA927469, AC002558, HY023336, S78234
      Consensus CDS
      CCDS11509.1
      UniProtKB/Swiss-Prot
      G3V1C4, P30260, Q16349, Q96F35
      Related
      ENSP00000066544.3, ENST00000066544.8
      Conserved Domains (3) summary
      COG0457
      Location:501 → 762
      TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
      sd00006
      Location:567 → 595
      TPR; TPR repeat [structural motif]
      pfam12895
      Location:17 → 92
      ANAPC3; Anaphase-promoting complex, cyclosome, subunit 3

    3. NM_001293089.3 → NP_001280018.1  cell division cycle protein 27 homolog isoform 3

      See identical proteins and their annotated locations for NP_001280018.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) uses two alternate in-frame splice sites in the central coding region, compared to variant 1, resulting in an isoform (3) that is shorter than isoform 1.
      Source sequence(s)
      AA927469, AC002558, HY023336, U00001
      Consensus CDS
      CCDS74090.1
      UniProtKB/TrEMBL
      G5EA36
      Related
      ENSP00000437339.1, ENST00000527547.5
      Conserved Domains (5) summary
      COG0457
      Location:500 → 761
      TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
      sd00006
      Location:566 → 594
      TPR; TPR repeat [structural motif]
      pfam00515
      Location:634 → 666
      TPR_1; Tetratricopeptide repeat
      pfam12895
      Location:17 → 92
      ANAPC3; Anaphase-promoting complex, cyclosome, subunit 3
      pfam13424
      Location:457 → 527
      TPR_12; Tetratricopeptide repeat

    4. NM_001293091.3 → NP_001280020.1  cell division cycle protein 27 homolog isoform 4

      See identical proteins and their annotated locations for NP_001280020.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) lacks an alternate exon in the 5' region and it thus differs in its 5' UTR and initiates translation at an alternate start codon, and it also uses an alternate in-frame splice site in the central coding region, compared to variant 1. The encoded isoform (4) has a distinct N-terminus and is shorter than isoform 1.
      Source sequence(s)
      AA927469, AC002558, AK296881, HY023336
      UniProtKB/TrEMBL
      B4DL80, E7EN31
      Conserved Domains (2) summary
      COG0457
      Location:440 → 701
      TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
      sd00006
      Location:506 → 534
      TPR; TPR repeat [structural motif]

    5. NM_001353035.2 → NP_001339964.1  cell division cycle protein 27 homolog isoform 5

      Status: REVIEWED

      Source sequence(s)
      AC002558
      Conserved Domains (3) summary
      COG0457
      Location:501 → 759
      TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
      sd00006
      Location:567 → 595
      TPR; TPR repeat [structural motif]
      pfam12895
      Location:17 → 92
      ANAPC3; Anaphase-promoting complex, cyclosome, subunit 3

    6. NM_001353047.2 → NP_001339976.1  cell division cycle protein 27 homolog isoform 6

      Status: REVIEWED

      Source sequence(s)
      AC002558
      Conserved Domains (3) summary
      COG0457
      Location:500 → 758
      TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
      sd00006
      Location:566 → 594
      TPR; TPR repeat [structural motif]
      pfam12895
      Location:17 → 92
      ANAPC3; Anaphase-promoting complex, cyclosome, subunit 3

    7. NM_001353049.2 → NP_001339978.1  cell division cycle protein 27 homolog isoform 7

      Status: REVIEWED

      Source sequence(s)
      AC002558
      Conserved Domains (2) summary
      COG0457
      Location:440 → 698
      TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
      sd00006
      Location:506 → 534
      TPR; TPR repeat [structural motif]

    8. NM_001353050.2 → NP_001339979.1  cell division cycle protein 27 homolog isoform 8

      Status: REVIEWED

      Source sequence(s)
      AC002558
      Conserved Domains (2) summary
      COG0457
      Location:404 → 665
      TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
      sd00006
      Location:470 → 498
      TPR; TPR repeat [structural motif]

    9. NM_001353051.2 → NP_001339980.1  cell division cycle protein 27 homolog isoform 9

      Status: REVIEWED

      Source sequence(s)
      AC002558
      Conserved Domains (3) summary
      COG0457
      Location:56 → 303
      TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
      TIGR02917
      Location:182 → 414
      PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
      sd00006
      Location:169 → 197
      TPR; TPR repeat [structural motif]

    RNA

    1. NR_148340.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC002558

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

      Range
      47117703..47189295 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017025485.3 → XP_016880974.1  cell division cycle protein 27 homolog isoform X7

    2. XM_017025484.3 → XP_016880973.1  cell division cycle protein 27 homolog isoform X6

    3. XM_047437230.1 → XP_047293186.1  cell division cycle protein 27 homolog isoform X5

    4. XM_011525548.4 → XP_011523850.1  cell division cycle protein 27 homolog isoform X4

      See identical proteins and their annotated locations for XP_011523850.1

      Conserved Domains (5) summary
      COG0457
      Location:446 → 707
      TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
      sd00006
      Location:512 → 540
      TPR; TPR repeat [structural motif]
      pfam00515
      Location:580 → 612
      TPR_1; Tetratricopeptide repeat
      pfam13181
      Location:684 → 714
      TPR_8; Tetratricopeptide repeat
      pfam13424
      Location:402 → 473
      TPR_12; Tetratricopeptide repeat

    5. XM_011525546.4 → XP_011523848.1  cell division cycle protein 27 homolog isoform X1

      Conserved Domains (5) summary
      COG0457
      Location:506 → 767
      TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
      sd00006
      Location:572 → 600
      TPR; TPR repeat [structural motif]
      pfam00515
      Location:640 → 672
      TPR_1; Tetratricopeptide repeat
      pfam12895
      Location:17 → 92
      ANAPC3; Anaphase-promoting complex, cyclosome, subunit 3
      pfam13424
      Location:463 → 533
      TPR_12; Tetratricopeptide repeat

    6. XM_011525549.3 → XP_011523851.1  cell division cycle protein 27 homolog isoform X4

      See identical proteins and their annotated locations for XP_011523851.1

      Conserved Domains (5) summary
      COG0457
      Location:446 → 707
      TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
      sd00006
      Location:512 → 540
      TPR; TPR repeat [structural motif]
      pfam00515
      Location:580 → 612
      TPR_1; Tetratricopeptide repeat
      pfam13181
      Location:684 → 714
      TPR_8; Tetratricopeptide repeat
      pfam13424
      Location:402 → 473
      TPR_12; Tetratricopeptide repeat

    7. XM_011525547.4 → XP_011523849.1  cell division cycle protein 27 homolog isoform X3

      Conserved Domains (5) summary
      COG0457
      Location:507 → 765
      TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
      sd00006
      Location:573 → 601
      TPR; TPR repeat [structural motif]
      pfam00515
      Location:641 → 673
      TPR_1; Tetratricopeptide repeat
      pfam12895
      Location:17 → 92
      ANAPC3; Anaphase-promoting complex, cyclosome, subunit 3
      pfam13424
      Location:463 → 534
      TPR_12; Tetratricopeptide repeat

    8. XM_047437229.1 → XP_047293185.1  cell division cycle protein 27 homolog isoform X2

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060941.1 Alternate T2T-CHM13v2.0

      Range
      47979197..48051640 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054318107.1 → XP_054174082.1  cell division cycle protein 27 homolog isoform X7

    2. XM_054318106.1 → XP_054174081.1  cell division cycle protein 27 homolog isoform X6

    3. XM_054318105.1 → XP_054174080.1  cell division cycle protein 27 homolog isoform X5

    4. XM_054318103.1 → XP_054174078.1  cell division cycle protein 27 homolog isoform X4

    5. XM_054318100.1 → XP_054174075.1  cell division cycle protein 27 homolog isoform X1

    6. XM_054318104.1 → XP_054174079.1  cell division cycle protein 27 homolog isoform X4

    7. XM_054318102.1 → XP_054174077.1  cell division cycle protein 27 homolog isoform X3

    8. XM_054318101.1 → XP_054174076.1  cell division cycle protein 27 homolog isoform X2

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P30260.2 GenPept UniProtKB/Swiss-Prot:P30260

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