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CTNNB1 catenin beta 1 [ Homo sapiens (human) ]

Gene ID: 1499, updated on 14-Nov-2024

Summary

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Official Symbol: CTNNB1provided by HGNC
Official Full Name: catenin beta 1provided by HGNC
Primary source: HGNC:HGNC:2514
See related: Ensembl:ENSG00000168036 MIM:116806; AllianceGenome:HGNC:2514
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: EVR7; CTNNB; MRD19; NEDSDV; armadillo
Summary: The protein encoded by this gene is part of a complex of proteins that constitute adherens junctions (AJs). AJs are necessary for the creation and maintenance of epithelial cell layers by regulating cell growth and adhesion between cells. The encoded protein also anchors the actin cytoskeleton and may be responsible for transmitting the contact inhibition signal that causes cells to stop dividing once the epithelial sheet is complete. Finally, this protein binds to the product of the APC gene, which is mutated in adenomatous polyposis of the colon. Mutations in this gene are a cause of colorectal cancer (CRC), pilomatrixoma (PTR), medulloblastoma (MDB), and ovarian cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2016]
Expression: Ubiquitous expression in placenta (RPKM 94.7), thyroid (RPKM 78.7) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

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See CTNNB1 in Genome Data Viewer

Location:: 3p22.1

Exon count:: 21

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	3	NC_000003.12 (41199505..41240443)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	3	NC_060927.1 (41214904..41255840)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	3	NC_000003.11 (41240996..41281934)

Chromosome 3 - NC_000003.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Tumor-derived hypoxic small extracellular vesicles promote endothelial cell migration and tube formation via ALS2/Rab5/beta-catenin signaling.
Title: Tumor-derived hypoxic small extracellular vesicles promote endothelial cell migration and tube formation via ALS2/Rab5/β-catenin signaling.
BRCC36 regulates beta-catenin ubiquitination to alleviate vascular calcification in chronic kidney disease.
Title: BRCC36 regulates β-catenin ubiquitination to alleviate vascular calcification in chronic kidney disease.
Movement disorder phenotype in CTNNB1-syndrome: A complex but recognizable phenomenology.
Title: Movement disorder phenotype in CTNNB1-syndrome: A complex but recognizable phenomenology.
MEN1 Deficiency-Driven Activation of the beta-Catenin-MGMT Axis Promotes Pancreatic Neuroendocrine Tumor Growth and Confers Temozolomide Resistance.
Title: MEN1 Deficiency-Driven Activation of the β-Catenin-MGMT Axis Promotes Pancreatic Neuroendocrine Tumor Growth and Confers Temozolomide Resistance.
Accumulated beta-catenin is associated with human atrial fibrosis and atrial fibrillation.
Title: Accumulated β-catenin is associated with human atrial fibrosis and atrial fibrillation.
YAP1-induced RBM24 promotes the tumorigenesis of triple-negative breast cancer through the beta-catenin pathway.
Title: YAP1-induced RBM24 promotes the tumorigenesis of triple-negative breast cancer through the β-catenin pathway.
SLC13A3 is a major effector downstream of activated beta-catenin in liver cancer pathogenesis.
Title: SLC13A3 is a major effector downstream of activated β-catenin in liver cancer pathogenesis.
Exosomal lncRNA USP30-AS1 activates the Wnt/beta-catenin signaling pathway to promote cervical cancer progression via stabilization of beta-catenin by USP30.
Title: Exosomal lncRNA USP30-AS1 activates the Wnt/β-catenin signaling pathway to promote cervical cancer progression via stabilization of β-catenin by USP30.
Specificity protein 1/3 regulate T-cell acute lymphoblastic leukemia cell proliferation and apoptosis through beta-catenin by acting as targets of miR-495-3p.
Title: Specificity protein 1/3 regulate T-cell acute lymphoblastic leukemia cell proliferation and apoptosis through β-catenin by acting as targets of miR-495-3p.
Regulation of the WNT-CTNNB1 signaling pathway by severe fever with thrombocytopenia syndrome virus in a cap-snatching manner.
Title: Regulation of the WNT-CTNNB1 signaling pathway by severe fever with thrombocytopenia syndrome virus in a cap-snatching manner.

Submit: New GeneRIF Correction See all GeneRIFs (2509)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description	Tests
Colorectal cancer MedGen: C0346629 OMIM: 114500 GeneReviews: Lynch Syndrome	not available
Exudative vitreoretinopathy 7 MedGen: C4539767 OMIM: 617572 GeneReviews: Not available	not available
Hepatocellular carcinoma MedGen: C2239176 OMIM: 114550 GeneReviews: Not available	not available
Medulloblastoma MedGen: C0025149 OMIM: 155255 GeneReviews: Not available	not available
Ovarian neoplasm MedGen: C0919267 GeneReviews: Not available	not available
Pilomatrixoma MedGen: C0206711 OMIM: 132600 GeneReviews: Not available	not available
Severe intellectual disability-progressive spastic diplegia syndrome MedGen: C3554449 OMIM: 615075 GeneReviews: CTNNB1 Neurodevelopmental Disorder	not available

Copy number response

Description
Copy number response Triplosensitivity No evidence available (Last evaluated 2017-11-22) ClinGen Genome Curation Page Haploinsufficency Sufficient evidence for dosage pathogenicity (Last evaluated 2017-11-22) ClinGen Genome Curation PagePubMed

EBI GWAS Catalog

Description
Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture. EBI GWAS Catalog EBI GWAS CatalogPubMed
Twenty bone-mineral-density loci identified by large-scale meta-analysis of genome-wide association studies. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Replication interactions

Interaction	Pubs
Knockdown of Beta-catenin (CTNNB1) and transcription factor 4 (TCF4) by siRNA enhances HIV-1 transcription in astrocytes	PubMed

Protein interactions

Protein	Gene	Interaction	Pubs
Envelope surface glycoprotein gp120	env	HIV-1 gp120 downregulates the expression of beta-catenin in primary human osteoblasts	PubMed
Nef	nef	HIV-1 NL4-3, SF2, NA7, and 8161k9 Nef alleles bind to CTNNB1 (b-catenin) in 293T cells and Jurkat T cells	PubMed
	nef	HIV-1 Nef interacts with beta-catenin by a pull-down assay using purified recombinant proteins. The D186A and F191A mutations in Nef abrogate the binding	PubMed
Tat	tat	HIV-1 Tat C induces phosphorylation of adherens junction proteins VE-cadherin and beta-catenin in human brain microvascular endothelial cells	PubMed
	tat	TCF4 and beta-catenin proteins inhibit docking of HIV-1 Tat at the TAR region of the HIV-1 LTR	PubMed
	tat	HIV-1 Tat-mediated downregulation of beta-catenin/Wnt signaling is dependent on the core and cysteine-rich domains of Tat. Clade C Tat lacks a dicysteine motif (C30C31) and does not downregulate beta-catenin signaling	PubMed
	tat	HIV-1 Tat and methamphetamine downregulates beta-catenin signaling and also suppresses expression of LEF-1, a key partner of beta-catenin to regulate cognate gene expression	PubMed
	tat	Axin1 regulates HIV-1 Tat-mediated transcription, which requires beta-catenin and TCF4	PubMed
Vpu	vpu	HIV-1 Vpu is a strong competitive inhibitor of beta-TrCP and impairs the degradation of SCF-beta-TrCP substrates such as IKBalpha, ATF4 and beta-catenin	PubMed
	vpu	HIV-1 Vpu reduces the beta-catenin interaction with E-cadherin and the Vpu-mediated dissociation of beta-catenin with E-cadherin enhances particle release	PubMed
	vpu	HIV-1 Vpu S61A mutant efficiently interacts with endogenous betaTrCP and strongly stabilizes beta-catenin	PubMed
retropepsin	gag-pol	Positional proteomics analysis identifies the cleavage of human catenin (cadherin-associated protein), beta 1, 88kDa (CTNNB1) at amino acid residues 46-47 by the HIV-1 protease	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Ctnnb1 (e-PCR), detects polymorphism
- UniSTS:508428

PMC130963P1 (e-PCR)
- UniSTS:270616

PMC130963P2 (e-PCR)
- UniSTS:270617

GDB:435507 (e-PCR)
- UniSTS:157235

RH123357 (e-PCR)
- UniSTS:135733

PMC15782P1 (e-PCR)
- UniSTS:271430

PMC15782P2 (e-PCR)
- UniSTS:271431

PMC123056P1 (e-PCR)
- UniSTS:270433

G42968 (e-PCR)
- UniSTS:94848

PMC21165P1 (e-PCR)
- UniSTS:272017

EST12H1 (e-PCR)
- UniSTS:263086

SHGC-30856 (e-PCR)
- UniSTS:78024

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables DNA-binding transcription factor binding	IPI Inferred from Physical Interaction more info	PubMed
enables DNA-binding transcription factor binding	ISS Inferred from Sequence or Structural Similarity more info
enables I-SMAD binding	IPI Inferred from Physical Interaction more info	PubMed
enables RNA polymerase II-specific DNA-binding transcription factor binding	IDA Inferred from Direct Assay more info	PubMed
enables RNA polymerase II-specific DNA-binding transcription factor binding	IPI Inferred from Physical Interaction more info	PubMed
enables SMAD binding	IPI Inferred from Physical Interaction more info	PubMed
enables alpha-catenin binding	IBA Inferred from Biological aspect of Ancestor more info
enables alpha-catenin binding	IPI Inferred from Physical Interaction more info	PubMed
enables cadherin binding	HDA more info	PubMed
enables cadherin binding	IBA Inferred from Biological aspect of Ancestor more info
enables cadherin binding	IPI Inferred from Physical Interaction more info	PubMed
enables chromatin binding	ISS Inferred from Sequence or Structural Similarity more info
enables disordered domain specific binding	IEA Inferred from Electronic Annotation more info
enables enzyme binding	IPI Inferred from Physical Interaction more info	PubMed
enables histone methyltransferase binding	ISS Inferred from Sequence or Structural Similarity more info
enables kinase binding	IPI Inferred from Physical Interaction more info	PubMed
enables nuclear estrogen receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables nuclear receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables nuclear receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables nuclear receptor binding	TAS Traceable Author Statement more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase binding	IEA Inferred from Electronic Annotation more info
enables protein phosphatase binding	IBA Inferred from Biological aspect of Ancestor more info
enables signaling receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables transcription coactivator activity	IBA Inferred from Biological aspect of Ancestor more info
enables transcription coactivator activity	IDA Inferred from Direct Assay more info	PubMed
enables transcription coactivator activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables transcription coregulator binding	ISS Inferred from Sequence or Structural Similarity more info
enables transcription corepressor binding	IPI Inferred from Physical Interaction more info	PubMed
enables transmembrane transporter binding	IPI Inferred from Physical Interaction more info	PubMed
enables ubiquitin protein ligase binding	EXP Inferred from Experiment more info	PubMed

Process	Evidence Code	Pubs
involved_in MAPK cascade	IEA Inferred from Electronic Annotation more info
involved_in T cell differentiation in thymus	IEA Inferred from Electronic Annotation more info
involved_in acinar cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in adherens junction assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in anterior/posterior axis specification	IEA Inferred from Electronic Annotation more info
involved_in apoptotic signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in astrocyte-dopaminergic neuron signaling	IEA Inferred from Electronic Annotation more info
involved_in bone resorption	IEA Inferred from Electronic Annotation more info
involved_in branching involved in blood vessel morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in branching involved in ureteric bud morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in canonical Wnt signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in canonical Wnt signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in canonical Wnt signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in canonical Wnt signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in canonical Wnt signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in canonical Wnt signaling pathway	TAS Traceable Author Statement more info	PubMed
involved_in canonical Wnt signaling pathway involved in mesenchymal stem cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in cell adhesion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell fate specification	IEA Inferred from Electronic Annotation more info
involved_in cell maturation	IEA Inferred from Electronic Annotation more info
involved_in cell-cell adhesion	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell-cell adhesion mediated by cadherin	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell-matrix adhesion	IEA Inferred from Electronic Annotation more info
involved_in cellular response to growth factor stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to indole-3-methanol	IDA Inferred from Direct Assay more info	PubMed
involved_in central nervous system vasculogenesis	IEA Inferred from Electronic Annotation more info
involved_in chemical synaptic transmission	IEA Inferred from Electronic Annotation more info
involved_in chondrocyte differentiation	IEA Inferred from Electronic Annotation more info
involved_in cranial ganglion development	IEA Inferred from Electronic Annotation more info
involved_in cranial skeletal system development	IEA Inferred from Electronic Annotation more info
involved_in detection of muscle stretch	TAS Traceable Author Statement more info	PubMed
involved_in dorsal root ganglion development	IEA Inferred from Electronic Annotation more info
involved_in dorsal/ventral axis specification	IEA Inferred from Electronic Annotation more info
involved_in ectoderm development	IEA Inferred from Electronic Annotation more info
involved_in embryonic axis specification	IEA Inferred from Electronic Annotation more info
involved_in embryonic brain development	IEA Inferred from Electronic Annotation more info
involved_in embryonic digit morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in embryonic foregut morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in embryonic forelimb morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in embryonic heart tube development	IEA Inferred from Electronic Annotation more info
involved_in embryonic hindlimb morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in embryonic skeletal limb joint morphogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in endodermal cell fate commitment	IEA Inferred from Electronic Annotation more info
involved_in endothelial tube morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in epithelial cell differentiation involved in prostate gland development	IEA Inferred from Electronic Annotation more info
involved_in epithelial cell proliferation involved in prostate gland development	IEA Inferred from Electronic Annotation more info
involved_in epithelial to mesenchymal transition	TAS Traceable Author Statement more info	PubMed
involved_in epithelial tube branching involved in lung morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in establishment of blood-brain barrier	IEA Inferred from Electronic Annotation more info
involved_in establishment of blood-retinal barrier	IEA Inferred from Electronic Annotation more info
involved_in fibroblast growth factor receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in fungiform papilla formation	IEA Inferred from Electronic Annotation more info
involved_in gastrulation with mouth forming second	IEA Inferred from Electronic Annotation more info
involved_in genitalia morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in glial cell fate determination	IEA Inferred from Electronic Annotation more info
involved_in hair cell differentiation	TAS Traceable Author Statement more info	PubMed
involved_in hair follicle morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in hair follicle placode formation	IEA Inferred from Electronic Annotation more info
involved_in hindbrain development	IEA Inferred from Electronic Annotation more info
involved_in hypothalamus development	IEA Inferred from Electronic Annotation more info
involved_in in utero embryonic development	IEA Inferred from Electronic Annotation more info
involved_in layer formation in cerebral cortex	IEA Inferred from Electronic Annotation more info
involved_in lens morphogenesis in camera-type eye	IEA Inferred from Electronic Annotation more info
involved_in lung epithelial cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in lung induction	IEA Inferred from Electronic Annotation more info
involved_in lung-associated mesenchyme development	IEA Inferred from Electronic Annotation more info
involved_in male genitalia development	IEA Inferred from Electronic Annotation more info
involved_in mesenchymal cell proliferation involved in lung development	IEA Inferred from Electronic Annotation more info
involved_in mesenchymal stem cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in metanephros morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in midbrain dopaminergic neuron differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in myoblast proliferation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of DNA-templated transcription	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of angiogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of negative regulation of apoptotic process	TAS Traceable Author Statement more info	PubMed
involved_in negative regulation of canonical Wnt signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of cell population proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of chondrocyte differentiation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of gene expression	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of mitotic cell cycle, embryonic	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of oligodendrocyte differentiation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of osteoclast differentiation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of protein sumoylation	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in nephron tubule formation	IEA Inferred from Electronic Annotation more info
involved_in neural plate development	IEA Inferred from Electronic Annotation more info
involved_in neuroblast proliferation	IEA Inferred from Electronic Annotation more info
involved_in neuron fate determination	IEA Inferred from Electronic Annotation more info
involved_in neuron migration	IEA Inferred from Electronic Annotation more info
involved_in neuron projection extension	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in odontogenesis of dentin-containing tooth	IEA Inferred from Electronic Annotation more info
involved_in oligodendrocyte differentiation	IEA Inferred from Electronic Annotation more info
involved_in oocyte development	IEA Inferred from Electronic Annotation more info
involved_in osteoblast differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in osteoclast differentiation	IEA Inferred from Electronic Annotation more info
involved_in outflow tract morphogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in oviduct development	IEA Inferred from Electronic Annotation more info
involved_in pancreas development	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of DNA-templated transcription	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of MAPK cascade	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of apoptotic process	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of branching involved in lung morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cell differentiation	NAS Non-traceable Author Statement more info	PubMed
involved_in positive regulation of cell population proliferation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of determination of dorsal identity	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of endothelial cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of epithelial cell proliferation involved in prostate gland development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of epithelial to mesenchymal transition	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of epithelial to mesenchymal transition	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of fibroblast growth factor receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of gene expression	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of heparan sulfate proteoglycan biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of mesenchymal cell proliferation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of myoblast proliferation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of neuroblast proliferation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of neuron apoptotic process	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of odontoblast differentiation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of osteoblast differentiation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of skeletal muscle tissue development	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of stem cell proliferation	IEA Inferred from Electronic Annotation more info
acts_upstream_of positive regulation of telomere maintenance via telomerase	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of transcription by RNA polymerase II	TAS Traceable Author Statement more info	PubMed
involved_in positive regulation of transcription elongation by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in protein localization to cell surface	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein polyubiquitination	IDA Inferred from Direct Assay more info	PubMed
involved_in proximal/distal pattern formation	IEA Inferred from Electronic Annotation more info
involved_in regulation of T cell proliferation	IEA Inferred from Electronic Annotation more info
involved_in regulation of angiogenesis	TAS Traceable Author Statement more info	PubMed
involved_in regulation of calcium ion import	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of centriole-centriole cohesion	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of centromeric sister chromatid cohesion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of fibroblast proliferation	TAS Traceable Author Statement more info	PubMed
involved_in regulation of myelination	IEA Inferred from Electronic Annotation more info
involved_in regulation of nephron tubule epithelial cell differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of neurogenesis	NAS Non-traceable Author Statement more info	PubMed
involved_in regulation of neurogenesis	TAS Traceable Author Statement more info	PubMed
involved_in regulation of protein localization to cell surface	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of protein ubiquitination	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of secondary heart field cardioblast proliferation	IEA Inferred from Electronic Annotation more info
involved_in regulation of smooth muscle cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of synapse assembly	IEA Inferred from Electronic Annotation more info
involved_in regulation of timing of anagen	IEA Inferred from Electronic Annotation more info
involved_in renal inner medulla development	IEA Inferred from Electronic Annotation more info
involved_in renal outer medulla development	IEA Inferred from Electronic Annotation more info
involved_in renal vesicle formation	IEA Inferred from Electronic Annotation more info
involved_in response to estradiol	IDA Inferred from Direct Assay more info	PubMed
involved_in response to xenobiotic stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in smooth muscle cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in stem cell population maintenance	TAS Traceable Author Statement more info	PubMed
involved_in stem cell proliferation	IEA Inferred from Electronic Annotation more info
involved_in sympathetic ganglion development	ISS Inferred from Sequence or Structural Similarity more info
involved_in synapse organization	IEA Inferred from Electronic Annotation more info
involved_in synaptic vesicle clustering	IEA Inferred from Electronic Annotation more info
involved_in synaptic vesicle transport	IEA Inferred from Electronic Annotation more info
involved_in thymus development	IEA Inferred from Electronic Annotation more info
involved_in trachea formation	IEA Inferred from Electronic Annotation more info
involved_in transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in Schaffer collateral - CA1 synapse	IEA Inferred from Electronic Annotation more info
part_of Scrib-APC-beta-catenin complex	IEA Inferred from Electronic Annotation more info
part_of Wnt signalosome	NAS Non-traceable Author Statement more info	PubMed
located_in Z disc	IEA Inferred from Electronic Annotation more info
is_active_in adherens junction	IBA Inferred from Biological aspect of Ancestor more info
located_in adherens junction	IDA Inferred from Direct Assay more info	PubMed
located_in adherens junction	IMP Inferred from Mutant Phenotype more info	PubMed
located_in apical part of cell	IEA Inferred from Electronic Annotation more info
located_in apicolateral plasma membrane	IEA Inferred from Electronic Annotation more info
located_in basolateral plasma membrane	IDA Inferred from Direct Assay more info	PubMed
part_of beta-catenin destruction complex	IDA Inferred from Direct Assay more info	PubMed
part_of beta-catenin-ICAT complex	IEA Inferred from Electronic Annotation more info
part_of beta-catenin-TCF complex	IDA Inferred from Direct Assay more info	PubMed
part_of beta-catenin-TCF complex	IPI Inferred from Physical Interaction more info	PubMed
part_of beta-catenin-TCF7L2 complex	IDA Inferred from Direct Assay more info	PubMed
located_in bicellular tight junction	IEA Inferred from Electronic Annotation more info
part_of catenin complex	IBA Inferred from Biological aspect of Ancestor more info
part_of catenin complex	IDA Inferred from Direct Assay more info	PubMed
located_in cell cortex	IDA Inferred from Direct Assay more info	PubMed
located_in cell junction	IDA Inferred from Direct Assay more info	PubMed
located_in cell junction	TAS Traceable Author Statement more info	PubMed
located_in cell periphery	IDA Inferred from Direct Assay more info	PubMed
located_in cell-cell junction	IDA Inferred from Direct Assay more info	PubMed
located_in centrosome	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	TAS Traceable Author Statement more info
located_in euchromatin	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular exosome	HDA more info	PubMed
located_in fascia adherens	IEA Inferred from Electronic Annotation more info
part_of flotillin complex	IEA Inferred from Electronic Annotation more info
located_in focal adhesion	HDA more info	PubMed
located_in glutamatergic synapse	IEA Inferred from Electronic Annotation more info
located_in lamellipodium	IEA Inferred from Electronic Annotation more info
located_in lateral plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in microvillus membrane	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	TAS Traceable Author Statement more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in perinuclear region of cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	TAS Traceable Author Statement more info
located_in postsynaptic density, intracellular component	IEA Inferred from Electronic Annotation more info
located_in postsynaptic membrane	IEA Inferred from Electronic Annotation more info
located_in presynaptic active zone cytoplasmic component	IEA Inferred from Electronic Annotation more info
located_in presynaptic membrane	IEA Inferred from Electronic Annotation more info
part_of protein-DNA complex	IDA Inferred from Direct Assay more info	PubMed
part_of protein-containing complex	IDA Inferred from Direct Assay more info	PubMed
located_in spindle pole	IEA Inferred from Electronic Annotation more info
located_in synapse	ISS Inferred from Sequence or Structural Similarity more info
part_of transcription regulator complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: catenin beta-1

Names: catenin (cadherin-associated protein), beta 1, 88kDa

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_013302.2 RefSeqGene

Range

5055..45993

Download

GenBank, FASTA, Sequence Viewer (Graphics), LRG_1108

mRNA and Protein(s)

NM_001098209.2 → NP_001091679.1 catenin beta-1 isoform 1

See identical proteins and their annotated locations for NP_001091679.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) differs in the 3' UTR compared to variant 1. Variants 1, 2 and 3 encode the same isoform (1).

Source sequence(s)

AC104307, X87838

Consensus CDS

CCDS2694.1

UniProtKB/Swiss-Prot

A8K1L7, P35222, Q8NEW9, Q8NI94, Q9H391

UniProtKB/TrEMBL

A0A2R8YCH5

Related

ENSP00000379488.3, ENST00000396185.8

Conserved Domains (4) summary

smart00185
Location:350 → 390

ARM; Armadillo/beta-catenin-like repeats

COG5064
Location:142 → 431

SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]

sd00043
Location:402 → 427

ARM; armadillo repeat [structural motif]

pfam00514
Location:583 → 622

Arm; Armadillo/beta-catenin-like repeat
NM_001098210.2 → NP_001091680.1 catenin beta-1 isoform 1

See identical proteins and their annotated locations for NP_001091680.1

Status: REVIEWED

Description

Transcript Variant: This variant (3) differs in the 3' UTR compared to variant 1. Variants 1, 2 and 3 encode the same isoform (1).

Source sequence(s)

AC104307, DA216720, Z19054

Consensus CDS

CCDS2694.1

UniProtKB/Swiss-Prot

A8K1L7, P35222, Q8NEW9, Q8NI94, Q9H391

UniProtKB/TrEMBL

A0A2R8YCH5

Related

ENSP00000379486.3, ENST00000396183.7

Conserved Domains (4) summary

smart00185
Location:350 → 390

ARM; Armadillo/beta-catenin-like repeats

COG5064
Location:142 → 431

SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]

sd00043
Location:402 → 427

ARM; armadillo repeat [structural motif]

pfam00514
Location:583 → 622

Arm; Armadillo/beta-catenin-like repeat
NM_001330729.2 → NP_001317658.1 catenin beta-1 isoform 2

Status: REVIEWED

Description

Transcript Variant: This variant (4) differs in the 5' and 3' UTRs and the 5' coding region and initiates translation at a downstream start codon, compared to variant 1. It encodes isoform 2, which has a shorter N-terminus, compared to isoform 1.

Source sequence(s)

AC104307, AK294778, CA944934

Consensus CDS

CCDS87067.1

UniProtKB/TrEMBL

A0A2R8YCH5, B4DGU4, C9IZ65

Related

ENSP00000411226.1, ENST00000453024.6

Conserved Domains (4) summary

smart00185
Location:343 → 383

ARM; Armadillo/beta-catenin-like repeats

COG5064
Location:135 → 424

SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]

sd00043
Location:395 → 420

ARM; armadillo repeat [structural motif]

pfam00514
Location:576 → 615

Arm; Armadillo/beta-catenin-like repeat
NM_001904.4 → NP_001895.1 catenin beta-1 isoform 1

See identical proteins and their annotated locations for NP_001895.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2 and 3 encode the same isoform (1).

Source sequence(s)

AC104307, X87838

Consensus CDS

CCDS2694.1

UniProtKB/Swiss-Prot

A8K1L7, P35222, Q8NEW9, Q8NI94, Q9H391

UniProtKB/TrEMBL

A0A2R8YCH5

Related

ENSP00000344456.5, ENST00000349496.11

Conserved Domains (4) summary

smart00185
Location:350 → 390

ARM; Armadillo/beta-catenin-like repeats

COG5064
Location:142 → 431

SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]

sd00043
Location:402 → 427

ARM; armadillo repeat [structural motif]

pfam00514
Location:583 → 622

Arm; Armadillo/beta-catenin-like repeat

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000003.12 Reference GRCh38.p14 Primary Assembly

Range

41199505..41240443

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006712985.2 → XP_006713048.1 catenin beta-1 isoform X3

UniProtKB/TrEMBL

A0AAQ5BIC2

Related

ENSP00000520350.1, ENST00000715149.1

Conserved Domains (3) summary

smart00185
Location:350 → 390

ARM; Armadillo/beta-catenin-like repeats

cd00020
Location:399 → 518

ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...

sd00043
Location:402 → 427

ARM; armadillo repeat [structural motif]
XM_024453356.2 → XP_024309124.1 catenin beta-1 isoform X1

UniProtKB/Swiss-Prot

A8K1L7, P35222, Q8NEW9, Q8NI94, Q9H391

UniProtKB/TrEMBL

A0A2R8YCH5

Related

ENSP00000494053.1, ENST00000643977.1

Conserved Domains (4) summary

smart00185
Location:350 → 390

ARM; Armadillo/beta-catenin-like repeats

COG5064
Location:142 → 431

SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]

sd00043
Location:402 → 427

ARM; armadillo repeat [structural motif]

pfam00514
Location:583 → 622

Arm; Armadillo/beta-catenin-like repeat
XM_047447481.1 → XP_047303437.1 catenin beta-1 isoform X1

UniProtKB/Swiss-Prot

A8K1L7, P35222, Q8NEW9, Q8NI94, Q9H391
XM_047447477.1 → XP_047303433.1 catenin beta-1 isoform X1

UniProtKB/Swiss-Prot

A8K1L7, P35222, Q8NEW9, Q8NI94, Q9H391

Related

ENSP00000494677.1, ENST00000643297.1
XM_017005738.2 → XP_016861227.1 catenin beta-1 isoform X1

UniProtKB/Swiss-Prot

A8K1L7, P35222, Q8NEW9, Q8NI94, Q9H391

UniProtKB/TrEMBL

A0A2R8YCH5

Related

ENSP00000409302.2, ENST00000450969.6

Conserved Domains (4) summary

smart00185
Location:350 → 390

ARM; Armadillo/beta-catenin-like repeats

COG5064
Location:142 → 431

SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]

sd00043
Location:402 → 427

ARM; armadillo repeat [structural motif]

pfam00514
Location:583 → 622

Arm; Armadillo/beta-catenin-like repeat
XM_047447483.1 → XP_047303439.1 catenin beta-1 isoform X3
XM_047447478.1 → XP_047303434.1 catenin beta-1 isoform X1

UniProtKB/Swiss-Prot

A8K1L7, P35222, Q8NEW9, Q8NI94, Q9H391
XM_047447480.1 → XP_047303436.1 catenin beta-1 isoform X1

UniProtKB/Swiss-Prot

A8K1L7, P35222, Q8NEW9, Q8NI94, Q9H391
XM_047447482.1 → XP_047303438.1 catenin beta-1 isoform X2

UniProtKB/TrEMBL

B4DGU4, C9IZ65
XM_047447479.1 → XP_047303435.1 catenin beta-1 isoform X1

UniProtKB/Swiss-Prot

A8K1L7, P35222, Q8NEW9, Q8NI94, Q9H391