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    MOV10 Mov10 RNA helicase [ Homo sapiens (human) ]

    Gene ID: 4343, updated on 28-Oct-2024

    Summary

    Official Symbol
    MOV10provided by HGNC
    Official Full Name
    Mov10 RNA helicaseprovided by HGNC
    Primary source
    HGNC:HGNC:7200
    See related
    Ensembl:ENSG00000155363 MIM:610742; AllianceGenome:HGNC:7200
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    gb110; fSAP113
    Summary
    Enables 5'-3' RNA helicase activity and RNA binding activity. Involved in defense response to virus and mRNA destabilization. Located in P-body and cytosol. Implicated in hypertension. [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Ubiquitous expression in placenta (RPKM 19.5), small intestine (RPKM 18.6) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See MOV10 in Genome Data Viewer
    Location:
    1p13.2
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (112674439..112700739)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (112687020..112713316)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (113217061..113243361)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene capping actin protein of muscle Z-line subunit alpha 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1201 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:113180612-113181112 Neighboring gene RNA, U7 small nuclear 70 pseudogene Neighboring gene small nucleolar RNA U13 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1202 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:113234976-113235476 Neighboring gene Sharpr-MPRA regulatory region 4682 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:113242906-113243833 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:113246858-113247412 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1517 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1203 Neighboring gene ras homolog family member C Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1518 Neighboring gene Sharpr-MPRA regulatory region 11832 Neighboring gene protein phosphatase, Mg2+/Mn2+ dependent 1J

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    Copy number response

    Description
    Copy number response
    Triplosensitivity

    No evidence available (Last evaluated 2019-03-12)

    ClinGen Genome Curation Page
    Haploinsufficency

    No evidence available (Last evaluated 2019-03-12)

    ClinGen Genome Curation PagePubMed

    EBI GWAS Catalog

    Description
    Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk.
    EBI GWAS Catalog
    Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure.
    EBI GWAS Catalog
    Genome-wide association study in Chinese identifies novel loci for blood pressure and hypertension.
    EBI GWAS Catalog

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    siRNA-mediated knockdown of endogeneous MOV10 impairs HIV-1 virus production and Gag expression in 293T cells PubMed

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env Tandem affinity purification and mass spectrometry analysis identify Moloney leukemia virus 10 homolog (MOV10), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    Gag-Pol gag-pol Tandem affinity purification and mass spectrometry analysis identify Moloney leukemia virus 10 homolog (MOV10), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    Nef nef Tandem affinity purification and mass spectrometry analysis identify Moloney leukemia virus 10 homolog (MOV10), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    Pr55(Gag) gag siRNA-mediated knockdown of endogeneous MOV10 impairs HIV-1 virus production and Gag expression in 293T cells PubMed
    gag Tandem affinity purification and mass spectrometry analysis identify Moloney leukemia virus 10 homolog (MOV10), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    gag Overexpression of the Mov10 mutants, G681A/D682A and R730A/N731A, impairs Mov10-mediated decrease of HIV-1 Gag expression in cells and the incorporation efficiency of Mov10 into particles PubMed
    gag The efficiency of incorporation of Mov10, A3G, and A3F into viral particles, which contains both HIV-1 Gag and genomic RNA, is much higher than that of the other P-body proteins AGO2, DCP1a, DCP2, and DDX6 PubMed
    gag Mov10 overexpression results in translational repression of HIV-1 Gag and that AGO2 and/or RISC function is required to induce this translational repression PubMed
    gag Overexpression of A3G and Mov10 decreases the efficiency of HIV-1 Gag processing in the virus-producing cells PubMed
    gag MOV10 is packaged into HIV-1 virions in an RNA-dependent manner via an interaction with the NC domain of Gag PubMed
    gag HIV-1 Gag binds to the N-terminal amino acids 261-305 region of MOV10. The seven helicase motifs of MOV10 are not required for its interaction with Gag, while all but one of them (motif V) are required for MOV10 packaging into virions PubMed
    Rev rev HIV-1 Rev requires MOV10 helicase activity for enhanced function PubMed
    rev HIV-1 Rev interacts with Rev PubMed
    rev Rev/RRE expression is specifically upregulated by MOV10 in a Rev/RRE-dependent reprter gene assay PubMed
    nucleocapsid gag MOV10 is packaged into HIV-1 virions in an RNA-dependent manner via an interaction with the NC domain of Gag PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ32791, KIAA1631, DKFZp667O1423

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables 5'-3' RNA helicase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables RNA binding HDA PubMed 
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables RNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in P granule IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in P-body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasmic ribonucleoprotein granule IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasmic stress granule IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in extracellular space HDA PubMed 
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    helicase MOV-10
    Names
    Mov10 RISC complex RNA helicase
    Mov10, Moloney leukemia virus 10, homolog
    armitage homolog
    functional spliceosome-associated protein 113
    moloney leukemia virus 10 protein
    putative helicase MOV-10
    NP_001123551.1
    NP_001273001.1
    NP_001308253.1
    NP_001356436.1
    NP_001376491.1
    NP_001376492.1
    NP_066014.1
    XP_024302905.1
    XP_047277027.1
    XP_047277030.1
    XP_047277033.1
    XP_047277036.1
    XP_047277038.1
    XP_054192645.1
    XP_054192646.1
    XP_054192647.1
    XP_054192648.1
    XP_054192649.1
    XP_054192650.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001130079.3NP_001123551.1  helicase MOV-10 isoform 1

      See identical proteins and their annotated locations for NP_001123551.1

      Status: VALIDATED

      Source sequence(s)
      AL603832
      Consensus CDS
      CCDS853.1
      UniProtKB/Swiss-Prot
      Q5JR03, Q8TEF0, Q9BSY3, Q9BUJ9, Q9HCE1
      UniProtKB/TrEMBL
      B7Z700
      Conserved Domains (2) summary
      cd18808
      Location:734939
      SF1_C_Upf1; C-terminal helicase domain of Upf1-like family helicases
      cd18038
      Location:498733
      DEXXQc_Helz-like; DEXXQ/H-box helicase domain of Helz-like helicase
    2. NM_001286072.2NP_001273001.1  helicase MOV-10 isoform 2

      See identical proteins and their annotated locations for NP_001273001.1

      Status: VALIDATED

      Source sequence(s)
      AL603832
      Consensus CDS
      CCDS65615.1
      UniProtKB/TrEMBL
      A0A8I5KZ07, Q5JR04
      Related
      ENSP00000358658.1, ENST00000369644.5
      Conserved Domains (2) summary
      cd18808
      Location:678883
      SF1_C_Upf1; C-terminal helicase domain of Upf1-like family helicases
      cd18038
      Location:442677
      DEXXQc_Helz-like; DEXXQ/H-box helicase domain of Helz-like helicase
    3. NM_001321324.2NP_001308253.1  helicase MOV-10 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL603832
      Consensus CDS
      CCDS853.1
      UniProtKB/Swiss-Prot
      Q5JR03, Q8TEF0, Q9BSY3, Q9BUJ9, Q9HCE1
      UniProtKB/TrEMBL
      B7Z700
      Related
      ENSP00000358659.1, ENST00000369645.6
      Conserved Domains (2) summary
      cd18808
      Location:734939
      SF1_C_Upf1; C-terminal helicase domain of Upf1-like family helicases
      cd18038
      Location:498733
      DEXXQc_Helz-like; DEXXQ/H-box helicase domain of Helz-like helicase
    4. NM_001369507.1NP_001356436.1  helicase MOV-10 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL603832
      Consensus CDS
      CCDS853.1
      UniProtKB/Swiss-Prot
      Q5JR03, Q8TEF0, Q9BSY3, Q9BUJ9, Q9HCE1
      UniProtKB/TrEMBL
      B7Z700
      Related
      ENSP00000350028.2, ENST00000357443.2
      Conserved Domains (2) summary
      cd18808
      Location:734939
      SF1_C_Upf1; C-terminal helicase domain of Upf1-like family helicases
      cd18038
      Location:498733
      DEXXQc_Helz-like; DEXXQ/H-box helicase domain of Helz-like helicase
    5. NM_001389562.1NP_001376491.1  helicase MOV-10 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL603832
      Consensus CDS
      CCDS65615.1
      UniProtKB/TrEMBL
      A0A8I5KZ07, Q5JR04
      Related
      ENSP00000510374.1, ENST00000686097.1
      Conserved Domains (2) summary
      cd18808
      Location:678883
      SF1_C_Upf1; C-terminal helicase domain of Upf1-like family helicases
      cd18038
      Location:442677
      DEXXQc_Helz-like; DEXXQ/H-box helicase domain of Helz-like helicase
    6. NM_001389563.1NP_001376492.1  helicase MOV-10 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL603832
      Consensus CDS
      CCDS65615.1
      UniProtKB/TrEMBL
      A0A8I5KZ07, Q5JR04
      Conserved Domains (2) summary
      cd18808
      Location:678883
      SF1_C_Upf1; C-terminal helicase domain of Upf1-like family helicases
      cd18038
      Location:442677
      DEXXQc_Helz-like; DEXXQ/H-box helicase domain of Helz-like helicase
    7. NM_020963.5NP_066014.1  helicase MOV-10 isoform 1

      See identical proteins and their annotated locations for NP_066014.1

      Status: VALIDATED

      Source sequence(s)
      AL603832
      Consensus CDS
      CCDS853.1
      UniProtKB/Swiss-Prot
      Q5JR03, Q8TEF0, Q9BSY3, Q9BUJ9, Q9HCE1
      UniProtKB/TrEMBL
      B7Z700
      Related
      ENSP00000399797.2, ENST00000413052.6
      Conserved Domains (2) summary
      cd18808
      Location:734939
      SF1_C_Upf1; C-terminal helicase domain of Upf1-like family helicases
      cd18038
      Location:498733
      DEXXQc_Helz-like; DEXXQ/H-box helicase domain of Helz-like helicase

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      112674439..112700739
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047421080.1XP_047277036.1  helicase MOV-10 isoform X2

    2. XM_047421082.1XP_047277038.1  helicase MOV-10 isoform X2

    3. XM_024447137.2XP_024302905.1  helicase MOV-10 isoform X3

      UniProtKB/TrEMBL
      A0A8I5KXC3
      Conserved Domains (2) summary
      cd18038
      Location:498733
      DEXXQc_Helz-like; DEXXQ/H-box helicase domain of Helz-like helicase
      pfam13087
      Location:698836
      AAA_12; AAA domain
    4. XM_047421071.1XP_047277027.1  helicase MOV-10 isoform X1

      UniProtKB/TrEMBL
      Q5JR04
    5. XM_047421077.1XP_047277033.1  helicase MOV-10 isoform X1

      UniProtKB/TrEMBL
      Q5JR04
    6. XM_047421074.1XP_047277030.1  helicase MOV-10 isoform X1

      UniProtKB/TrEMBL
      Q5JR04

    RNA

    1. XR_007060173.1 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      112687020..112713316
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054336673.1XP_054192648.1  helicase MOV-10 isoform X2

    2. XM_054336674.1XP_054192649.1  helicase MOV-10 isoform X2

    3. XM_054336675.1XP_054192650.1  helicase MOV-10 isoform X3

    4. XM_054336670.1XP_054192645.1  helicase MOV-10 isoform X1

      UniProtKB/TrEMBL
      Q5JR04
    5. XM_054336672.1XP_054192647.1  helicase MOV-10 isoform X1

      UniProtKB/TrEMBL
      Q5JR04
    6. XM_054336671.1XP_054192646.1  helicase MOV-10 isoform X1

      UniProtKB/TrEMBL
      Q5JR04

    RNA

    1. XR_008486048.1 RNA Sequence