Masp1 MBL associated serine protease 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Masp1provided by RGD
Official Full Name: MBL associated serine protease 1provided by RGD
Primary source: RGD:620213
See related: EnsemblRapid:ENSRNOG00000001827 AllianceGenome:RGD:620213
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Masp3; Masp1/3
Summary: Enables several functions, including calcium-dependent protein binding activity; protein homodimerization activity; and serine-type endopeptidase activity. Predicted to be involved in complement activation, lectin pathway and negative regulation of complement activation. Located in extracellular space. Human ortholog(s) of this gene implicated in 3MC syndrome 1. Orthologous to human MASP1 (MBL associated serine protease 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Liver (RPKM 252.8), Muscle (RPKM 81.6) and 6 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 11q23

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	11	NC_086029.1 (90839081..90909922)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	11	NC_051346.1 (77334794..77405271)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	11	NC_005110.4 (80736424..80806278)

Chromosome 11 - NC_086029.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Flexibility in MASP-1 and MASP-2 provides insight on lectin pathway activation.
Title: Flexibility in Mannan-Binding Lectin-Associated Serine Proteases-1 and -2 Provides Insight on Lectin Pathway Activation.
we present the first structure of such a complex in the form of the collagen-like domain of mannan-binding lectin and the binding domain of its associated protease MASP-1
Title: Structural basis of mannan-binding lectin recognition by its associated serine protease MASP-1: implications for complement activation.
MASP-1 probably enhances complement activation triggered by MBP.MASP-2 complexes, but it cannot initiate activation itself
Title: Two mechanisms for mannose-binding protein modulation of the activity of its associated serine proteases.

Submit: New GeneRIF Correction

General gene information

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Markers

RH140729 (e-PCR)
- UniSTS:222795

RH129005 (e-PCR)
- UniSTS:212313

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables calcium ion binding	IDA Inferred from Direct Assay more info	PubMed
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables calcium ion binding	ISO Inferred from Sequence Orthology more info
enables calcium ion binding	ISS Inferred from Sequence or Structural Similarity more info
enables calcium-dependent protein binding	IEA Inferred from Electronic Annotation more info
enables calcium-dependent protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables calcium-dependent protein binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables peptidase activity	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	IEA Inferred from Electronic Annotation more info
enables protein homodimerization activity	IPI Inferred from Physical Interaction more info	PubMed
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables serine-type endopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables serine-type endopeptidase activity	IDA Inferred from Direct Assay more info	PubMed
enables serine-type endopeptidase activity	IEA Inferred from Electronic Annotation more info
enables serine-type endopeptidase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in complement activation	IEA Inferred from Electronic Annotation more info
involved_in complement activation	NAS Non-traceable Author Statement more info	PubMed
involved_in complement activation, lectin pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in complement activation, lectin pathway	IEA Inferred from Electronic Annotation more info
involved_in complement activation, lectin pathway	ISO Inferred from Sequence Orthology more info
involved_in complement activation, lectin pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in innate immune response	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of complement activation	ISO Inferred from Sequence Orthology more info
involved_in proteolysis	IEA Inferred from Electronic Annotation more info
involved_in zymogen activation	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular space	IEA Inferred from Electronic Annotation more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: mannan-binding lectin serine protease 1

Names: MASP-1; complement factor MASP-3; complement-activating component of Ra-reactive factor; mannan-binding lectin serine peptidase 1; mannan-binding lectin serine protease 2-like; mannose-binding lectin-associated serine protease 1; mannose-binding protein associated serine protease-1; mannose-binding protein-associated serine protease; ra-reactive factor serine protease p100; raRF; serine protease 5; serine protease MASP1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_022257.2 → NP_071593.2 mannan-binding lectin serine protease 1 precursor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000011

UniProtKB/Swiss-Prot

O09020, Q5U365, Q8CG41, Q8CHN8, Q9JJS9

UniProtKB/TrEMBL

A0A0H2UHA1

Related

ENSRNOP00000079792.1, ENSRNOT00000094154.2

Conserved Domains (6) summary

cd00033
Location:306 → 368

CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system

PHA02639
Location:305 → 438

PHA02639; EEV host range protein; Provisional

cd00041
Location:33 → 142

CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.

cd00190
Location:454 → 699

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

pfam00431
Location:190 → 299

CUB; CUB domain

pfam14670
Location:158 → 186

FXa_inhibition; Coagulation Factor Xa inhibitory site

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086029.1 Reference GRCr8

Range

90839081..90909922

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006248526.5 → XP_006248588.1 mannan-binding lectin serine protease 1 isoform X1

UniProtKB/TrEMBL

A0A8I5ZL57

Related

ENSRNOP00000078578.2, ENSRNOT00000111260.2

Conserved Domains (6) summary

cd00033
Location:306 → 368

CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system

smart00020
Location:454 → 715

Tryp_SPc; Trypsin-like serine protease

cd00041
Location:33 → 142

CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.

cd00190
Location:455 → 716

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

pfam00431
Location:190 → 299

CUB; CUB domain

pfam14670
Location:158 → 186

FXa_inhibition; Coagulation Factor Xa inhibitory site
XM_008768804.4 → XP_008767026.1 mannan-binding lectin serine protease 1 isoform X2

See identical proteins and their annotated locations for XP_008767026.1

UniProtKB/TrEMBL

A6JS17

Related

ENSRNOP00000044812.3, ENSRNOT00000047678.6

Conserved Domains (4) summary

cd00033
Location:306 → 368

CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system

cd00041
Location:33 → 142

CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.

pfam00431
Location:190 → 299

CUB; CUB domain

pfam14670
Location:158 → 186

FXa_inhibition; Coagulation Factor Xa inhibitory site