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    ZCCHC24 zinc finger CCHC-type containing 24 [ Homo sapiens (human) ]

    Gene ID: 219654, updated on 2-Nov-2024

    Summary

    Official Symbol
    ZCCHC24provided by HGNC
    Official Full Name
    zinc finger CCHC-type containing 24provided by HGNC
    Primary source
    HGNC:HGNC:26911
    See related
    Ensembl:ENSG00000165424 AllianceGenome:HGNC:26911
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    Z3CXXC8; C10orf56
    Summary
    Enables RNA binding activity. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in brain (RPKM 26.2), fat (RPKM 23.1) and 23 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See ZCCHC24 in Genome Data Viewer
    Location:
    10q22.3
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (79382325..79445624, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (80251666..80314699, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (81142081..81205380, complement)

    Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:80827637-80828482 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3623 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:80832039-80832542 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:80839841-80840350 Neighboring gene hESC enhancers GRCh37_chr10:80843535-80844106 and GRCh37_chr10:80844107-80844676 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2528 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:80847474-80848460 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:80848461-80849447 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:80850069-80850570 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:80850571-80851070 Neighboring gene CRISPRi-FlowFISH-validated PPIF regulatory elements GRCh37_chr10:80853442-80853942 and GRCh37_chr10:80853471-80853971 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:80856811-80857382 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3625 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:80860971-80861854 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:80861855-80862738 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:80862739-80863620 Neighboring gene ReSE screen-validated silencer GRCh37_chr10:80867111-80867288 Neighboring gene zinc finger MIZ-type containing 1 Neighboring gene HNF1 motif-containing MPRA enhancer 157 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:80872521-80873111 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:80873702-80874292 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:80873112-80873701 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:80874293-80874881 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3626 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2529 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:80886414-80886932 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:80889167-80889808 Neighboring gene CRISPRi-FlowFISH-validated PPIF regulatory element GRCh37_chr10:80892363-80892863 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:80897004-80897684 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:80904675-80905613 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3627 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2531 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2532 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:80915969-80916820 Neighboring gene HNF1 motif-containing MPRA enhancer 4 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:80918523-80919372 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:80922057-80922728 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:80930785-80931574 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:80937580-80938196 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:80938197-80938813 Neighboring gene Sharpr-MPRA regulatory region 270 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:80941281-80941897 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr10:80943423-80944622 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:80944822-80945581 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:80947279-80947814 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:80947815-80948349 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:80949957-80950491 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3628 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:80960740-80961240 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:80961241-80961741 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3629 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:80969381-80970255 Neighboring gene VISTA enhancer hs1767 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:80984385-80985122 Neighboring gene Sharpr-MPRA regulatory region 8427 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:80996160-80996788 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:80996789-80997417 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:80999304-80999932 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:80999933-81000560 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:81001601-81002552 Neighboring gene CRISPRi-FlowFISH-validated PPIF regulatory elements GRCh37_chr10:81003385-81003885 and GRCh37_chr10:81003389-81003889 Neighboring gene CRISPRi-FlowFISH-validated PPIF regulatory element GRCh37_chr10:81004281-81005113 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3633 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3632 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3635 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3634 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2537 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:81007811-81008725 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:81008726-81009639 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3637 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:81015755-81016750 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:81016751-81017746 Neighboring gene Sharpr-MPRA regulatory region 1120 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:81023533-81024492 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3638 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:81025451-81026410 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:81033176-81034046 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:81034047-81034918 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:81034919-81035789 Neighboring gene ReSE screen-validated silencer GRCh37_chr10:81039443-81039612 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3639 Neighboring gene CRISPRi-FlowFISH-validated PPIF regulatory element GRCh37_chr10:81044989-81045489 Neighboring gene H3K4me1 hESC enhancers GRCh37_chr10:81046379-81047029 and GRCh37_chr10:81045728-81046378 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2538 Neighboring gene CRISPRi-FlowFISH-validated PPIF regulatory elements GRCh37_chr10:81053513-81054274 and GRCh37_chr10:81053559-81054389 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr10:81064163-81065362 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:81071537-81072037 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:81072795-81073294 Neighboring gene CRISPRi-FlowFISH-validated PPIF regulatory elements GRCh37_chr10:81076336-81076836 to GRCh37_chr10:81076368-81076868 Neighboring gene CRISPRi-FlowFISH-validated PPIF regulatory elements GRCh37_chr10:81077051-81077551 to GRCh37_chr10:81077572-81078072 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:81078090-81078665 Neighboring gene CRISPRi-FlowFISH-validated PPIF regulatory elements GRCh37_chr10:81080832-81081332 to GRCh37_chr10:81080873-81081373 Neighboring gene CRISPRi-FlowFISH-validated PPIF regulatory elements GRCh37_chr10:81082504-81083416 to GRCh37_chr10:81082920-81083420 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3643 Neighboring gene CRISPRi-FlowFISH-validated PPIF regulatory elements GRCh37_chr10:81088372-81088872 to GRCh37_chr10:81088582-81089082 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr10:81091043-81092242 Neighboring gene CRISPRi-FlowFISH-validated PPIF regulatory elements GRCh37_chr10:81106892-81107469 to GRCh37_chr10:81107706-81108206 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:81108973-81109473 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:81111476-81111976 Neighboring gene CRISPRi-FlowFISH-validated PPIF regulatory elements GRCh37_chr10:81112809-81113784 to GRCh37_chr10:81113845-81114345 Neighboring gene CRISPRi-FlowFISH-validated PPIF regulatory element GRCh37_chr10:81115805-81116305 Neighboring gene CRISPRi-FlowFISH-validated PPIF regulatory elements GRCh37_chr10:81134127-81134627 and GRCh37_chr10:81134130-81134914 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:81135469-81136005 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:81145819-81146746 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:81150060-81150645 Neighboring gene peptidylprolyl isomerase F Neighboring gene CRISPRi-FlowFISH-validated PPIF regulatory element GRCh37_chr10:81159191-81159691 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:81162702-81163510 Neighboring gene CRISPRi-FlowFISH-validated PPIF regulatory elements GRCh37_chr10:81163946-81164446 and GRCh37_chr10:81163953-81164453 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:81165127-81165934 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:81172654-81173164 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:81173165-81173673 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:81184235-81184736 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:81194851-81195489 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2541 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2542 Neighboring gene uncharacterized LOC105378383 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3647 Neighboring gene CRISPRi-FlowFISH-validated PPIF regulatory element GRCh37_chr10:81250836-81251336 Neighboring gene ReSE screen-validated silencer GRCh37_chr10:81257847-81258047 Neighboring gene tetrapeptide repeat homeobox 1 pseudogene 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Phenotypes

    EBI GWAS Catalog

    Description
    Genome-wide association study on dimethylarginines reveals novel AGXT2 variants associated with heart rate variability but not with overall mortality.
    EBI GWAS Catalog

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ90798

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables RNA binding HDA PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    zinc finger CCHC domain-containing protein 24
    Names
    zinc finger, 3CxxC-type 8
    zinc finger, CCHC domain containing 24

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_153367.4NP_699198.2  zinc finger CCHC domain-containing protein 24

      See identical proteins and their annotated locations for NP_699198.2

      Status: VALIDATED

      Source sequence(s)
      AL133481, BC053564
      Consensus CDS
      CCDS7359.1
      UniProtKB/Swiss-Prot
      Q5U5T9, Q8N2G6, Q8TAG0
      Related
      ENSP00000361411.3, ENST00000372336.4
      Conserved Domains (2) summary
      COG5222
      Location:33157
      COG5222; Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only]
      pfam17180
      Location:164230
      zf-3CxxC_2; Zinc-binding domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

      Range
      79382325..79445624 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011539452.4XP_011537754.1  zinc finger CCHC domain-containing protein 24 isoform X1

      See identical proteins and their annotated locations for XP_011537754.1

      Conserved Domains (2) summary
      pfam13695
      Location:95161
      zf-3CxxC; Zinc-binding domain
      pfam13696
      Location:5979
      zf-CCHC_2; Zinc knuckle

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060934.1 Alternate T2T-CHM13v2.0

      Range
      80251666..80314699 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054364999.1XP_054220974.1  zinc finger CCHC domain-containing protein 24 isoform X1

    2. XM_054365000.1XP_054220975.1  zinc finger CCHC domain-containing protein 24 isoform X2