Slc14a2 solute carrier family 14 member 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Slc14a2provided by RGD
Official Full Name: solute carrier family 14 member 2provided by RGD
Primary source: RGD:3689
See related: EnsemblRapid:ENSRNOG00000061714 AllianceGenome:RGD:3689
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: UrT1-C; UrT1-D; Slc14a2T; Slc14a2_v4; testSymbol
Summary: Enables urea transmembrane transporter activity. Involved in urea transport. Located in apical plasma membrane. Orthologous to human SLC14A2 (solute carrier family 14 member 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Restricted expression toward (RPKM 62.8) See more
Orthologs: human mouse all
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Genomic context

Location:: 18q12.3

Exon count:: 23

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	18	NC_086036.1 (73887575..74314546, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	18	NC_051353.1 (71612460..72039462, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	18	NC_005117.4 (74508070..74941389, complement)

Chromosome 18 - NC_086036.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Urea transporter UT-A1 as a novel drug target for hyponatremia.
Title: Urea transporter UT-A1 as a novel drug target for hyponatremia.
UT-A1 and AQP2 interactomes provide a snapshot of a dynamic process in which UT-A1 and AQP2 are produced in the rough endoplasmic reticulum, processed through the Golgi apparatus, delivered to endosomes that move into and out of the plasma membrane, and are regulated in the plasma membrane.
Title: Identification of UT-A1- and AQP2-interacting proteins in rat inner medullary collecting duct.
Data indicate that there are several alternative channels for urea in the rat inner medulla that could potentially contribute to the high urea permeabilities in thin limb segments.
Title: Alternative channels for urea in the inner medulla of the rat kidney.
Report thiourea analogs as inhibitors of UT-A mediated urea transport.
Title: Structure-activity analysis of thiourea analogs as inhibitors of UT-A and UT-B urea transporters.
Activation of cAMP/PKA increases 14-3-3gamma interactions with UT-A1 and stimulates MDM2-mediated UT-A1 ubiquitination and degradation, forming a novel regulatory mechanism of urea transport activity.
Title: Downregulation of urea transporter UT-A1 activity by 14-3-3 protein.
UT-A1 localized to the apical membrane in response to vasopressin was phosphorylated at Ser(486) and Ser(499).
Title: Vasopressin regulation of multisite phosphorylation of UT-A1 in the inner medullary collecting duct.
The highly stable expression of highly glycosylated UT-A3 on the cell membrane in kidney inner medulla suggests that UT-A3 may have an important function in urea reabsorption.
Title: Glycoforms of UT-A3 urea transporter with poly-N-acetyllactosamine glycosylation have enhanced transport activity.
new role of N-linked glycosylation in regulating UT-A1 activity by promoting UT-A1 trafficking into membrane lipid raft subdomains
Title: Mature N-linked glycans facilitate UT-A1 urea transporter lipid raft compartmentalization.
Study concluded that UT-B1 mediates the transepithelial movement of urea that occurs in specific distal regions of the rat gastrointestinal tract.
Title: UT-B1 mediates transepithelial urea flux in the rat gastrointestinal tract.
Suggest that responsiveness to vasopressin that observed with UT-A1 can be introduced into the unresponsive UT-A2 variant through the Lc segment that is unique to UT-A1. In UT-A3 the Lc segment plays no significant role in its activation by cAMP.
Title: Functional characterization of the central hydrophilic linker region of the urea transporter UT-A1: cAMP activation and snapin binding.

Submit: New GeneRIF Correction See all GeneRIFs (24)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables cell adhesion molecule binding	IEA Inferred from Electronic Annotation more info
enables cell adhesion molecule binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables urea transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables urea transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables urea transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables urea transmembrane transporter activity	NAS Non-traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in urea transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in urea transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in urea transport	IDA Inferred from Direct Assay more info	PubMed
involved_in urea transport	NAS Non-traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
located_in apical plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in apical plasma membrane	IEA Inferred from Electronic Annotation more info
located_in apical plasma membrane	ISO Inferred from Sequence Orthology more info
located_in basolateral plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: urea transporter 2

Names: plasma membrane urea transporter; solute carrier family 14 (urea transporter), member 2T; testName; urea transport protein; urea transporter UT-A2c; urea transporter UT-A2d; urea transporter, kidney

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.