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    MRH4 ATP-dependent RNA helicase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852816, updated on 29-Jun-2024

    Summary

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    Gene symbol
    MRH4
    Gene description
    ATP-dependent RNA helicase
    Primary source
    FungiDB:YGL064C
    Locus tag
    YGL064C
    See related
    SGD:S000003032; AllianceGenome:SGD:S000003032; VEuPathDB:YGL064C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables RNA helicase activity and mitochondrial ribosomal large subunit rRNA binding activity. Involved in RNA metabolic process and mitochondrial large ribosomal subunit assembly. Located in mitochondrial matrix. Orthologous to human DDX28 (DEAD-box helicase 28). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See MRH4 in Genome Data Viewer
    Location:
    chromosome: VII
    Exon count:
    1
    Sequence:
    Chromosome: VII; NC_001139.9 (381523..383208, complement)

    Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene deubiquitination module subunit SGF73 Neighboring gene GDP-Man:Man(1)GlcNAc(2)-PP-dolichol alpha-1,3-mannosyltransferase Neighboring gene pseudouridine synthase PUS2 Neighboring gene pyruvate carboxylase 1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001139.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A novel mitochondrial DEAD box protein (Mrh4) required for maintenance of mtDNA in Saccharomyces cerevisiae. Schmidt U, et al. FEMS Yeast Res, 2002 Aug. PMID 12702275
    2. The DEAD box protein Mrh4 functions in the assembly of the mitochondrial large ribosomal subunit. De Silva D, et al. Cell Metab, 2013 Nov 5. PMID 24206665, Free PMC Article
    3. The sequence of a 36.7 kb segment on the left arm of chromosome IV from Saccharomyces cerevisiae reveals 20 non-overlapping open reading frames (ORFs) including SIT4, FAD1, NAM1, RNA11, SIR2, NAT1, PRP9, ACT2 and MPS1 and 11 new ORFs. Sarén AM, et al. Yeast, 1997 Jan. PMID 9046088
    4. The yeast protein Mam33 functions in the assembly of the mitochondrial ribosome. Hillman GA, et al. J Biol Chem, 2019 Jun 21. PMID 31053642, Free PMC Article
    5. The DEAD-box helicase Mss116 plays distinct roles in mitochondrial ribogenesis and mRNA-specific translation. De Silva D, et al. Nucleic Acids Res, 2017 Jun 20. PMID 28520979, Free PMC Article

    See all (44) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA helicase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables RNA helicase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mitochondrial ribosomal large subunit rRNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in RNA metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrial large ribosomal subunit assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in mitochondrial matrix IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    ATP-dependent RNA helicase
    NP_011451.1
    • Mitochondrial ATP-dependent RNA helicase of the DEAD-box family; required for assembly of the large subunit of mitochondrial ribosomes; binds to the large subunit rRNA, 21S_rRNA; localizes to the matrix face of the mitochondrial inner membrane and associates with the large subunit precursor and with mature ribosomes

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001139.9 Reference assembly

      Range
      381523..383208 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180929.1 → NP_011451.1  TPA: ATP-dependent RNA helicase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011451.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A6ZUB2, D6VU77, P53166
      UniProtKB/TrEMBL
      B3LHD3, C7GW46, C8Z8I2, N1P3K8
      Conserved Domains (2) summary
      COG0513
      Location:137 → 560
      SrmB; Superfamily II DNA and RNA helicase [Replication, recombination and repair]
      cd17965
      Location:100 → 346
      DEADc_MRH4; DEAD-box helicase domain of ATP-dependent RNA helicase MRH4
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P53166.1

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