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    PXP2 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853575, updated on 22-Aug-2024

    Summary

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    Official Symbol
    PXP2
    Primary source
    FungiDB:YJR111C
    Locus tag
    YJR111C
    See related
    SGD:S000003872; AllianceGenome:SGD:S000003872; VEuPathDB:YJR111C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to enable peroxiredoxin activity. Predicted to be involved in cellular oxidant detoxification. Located in peroxisome. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See PXP2 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    1
    Sequence:
    Chromosome: X; NC_001142.9 (635855..636706, complement)

    Chromosome X - NC_001142.9Genomic Context describing neighboring genes Neighboring gene carbamoyl-phosphate synthase (glutamine-hydrolyzing) CPA2 Neighboring gene phosphatidylinositol-3-phosphatase YMR1 Neighboring gene MIND complex subunit NNF1 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001142.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification of New Fungal Peroxisomal Matrix Proteins and Revision of the PTS1 Consensus. Nötzel C, et al. Traffic, 2016 Oct. PMID 27392156
    2. Peroxisomal targeting of a protein phosphatase type 2C via mitochondrial transit. Stehlik T, et al. Nat Commun, 2020 May 12. PMID 32398688, Free PMC Article
    3. Definition of a High-Confidence Mitochondrial Proteome at Quantitative Scale. Morgenstern M, et al. Cell Rep, 2017 Jun 27. PMID 28658629, Free PMC Article
    4. Chemical-genetic profile analysis of five inhibitory compounds in yeast. Alamgir M, et al. BMC Chem Biol, 2010 Aug 6. PMID 20691087, Free PMC Article
    5. Integrating Rio1 activities discloses its nutrient-activated network in Saccharomyces cerevisiae. Iacovella MG, et al. Nucleic Acids Res, 2018 Sep 6. PMID 30011030, Free PMC Article

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables peroxiredoxin activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in cellular oxidant detoxification IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion HDA PubMed 
    located_in peroxisomal matrix IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in peroxisome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in peroxisome IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Pxp2p
    NP_012645.1
    • Peroxisomal matrix protein with naturally active promoter; well-conserved in fungi; localized to peroxisomes under physiological growth conditions; levels of some amino acids are altered upon both knockout and overexpression, suggesting potential involvement of Pxp2p in amino acid metabolism or related cellular metabolic processes (needs further study); GFP-fusion protein displays inherent dual localization with large proportion localizing to cytosol

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001142.9 Reference assembly

      Range
      635855..636706 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181769.1 → NP_012645.1  TPA: Pxp2p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012645.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VWT0, P47148
      UniProtKB/TrEMBL
      A6ZQ67, B3LQJ5, B5VLQ5, C7GM98, C8ZBQ9, G2WHB4, N1P8V3
      Conserved Domains (1) summary
      pfam02627
      Location:214 → 282
      CMD; Carboxymuconolactone decarboxylase family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P47148.1

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