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    mhc2daa major histocompatibility complex class II DAA gene [ Danio rerio (zebrafish) ]

    Gene ID: 368878, updated on 2-Nov-2024

    Summary

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    Official Symbol
    mhc2daaprovided by ZNC
    Official Full Name
    major histocompatibility complex class II DAA geneprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-980526-201
    See related
    Ensembl:ENSDARG00000031745 AllianceGenome:ZFIN:ZDB-GENE-980526-201
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    a1; a2; MHCII; mhcdaa; wu:fa93a04; zgc:103599; zgc:113853; zgc:113912; si:dz266f07.2; si:busm1-266f07.2
    Summary
    Predicted to act upstream of or within adaptive immune response and antigen processing and presentation of peptide or polysaccharide antigen via MHC class II. Predicted to be located in membrane. Predicted to be part of MHC class II protein complex. [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    all
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    Genomic context

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    See mhc2daa in Genome Data Viewer
    Location:
    chromosome: 8
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 8 NC_007119.7 (36471961..36475344, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 8 NC_007119.6 (36440010..36442894, complement)

    Chromosome 8 - NC_007119.7Genomic Context describing neighboring genes Neighboring gene si:busm1-194e12.8 Neighboring gene major histocompatibility complex class II DAB gene Neighboring gene solute carrier family 7 member 4 Neighboring gene uncharacterized LOC137496284

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Zebrafish Mhc class II alpha chain-encoding genes: polymorphism, expression, and function. Sültmann H, et al. Immunogenetics, 1993. PMID 8406613
    2. Zebrafish model for allogeneic hematopoietic cell transplantation not requiring preconditioning. Hess I, et al. Proc Natl Acad Sci U S A, 2013 Mar 12. PMID 23431192, Free PMC Article
    3. Essential role of IL-4 and IL-4Rα interaction in adaptive immunity of zebrafish: insight into the origin of Th2-like regulatory mechanism in ancient vertebrates. Zhu LY, et al. J Immunol, 2012 Jun 1. PMID 22547699
    4. Comprehensive analysis of MHC class II genes in teleost fish genomes reveals dispensability of the peptide-loading DM system in a large part of vertebrates. Dijkstra JM, et al. BMC Evol Biol, 2013 Nov 26. PMID 24279922, Free PMC Article
    5. RIP2 Is a Critical Regulator for NLRs Signaling and MHC Antigen Presentation but Not for MAPK and PI3K/Akt Pathways. Wu XM, et al. Front Immunol, 2018. PMID 29692779, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC103599, MGC113853, MGC113912, MGC192244

    Gene Ontology Provided by ZFIN

    Process Evidence Code Pubs
    acts_upstream_of_or_within adaptive immune response IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within antigen processing and presentation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within antigen processing and presentation of peptide or polysaccharide antigen via MHC class II IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within immune response IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within immune system process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of MHC class II protein complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    major histocompatibility complex class II DAA
    Names
    MHC class II integral membrane protein alpha chain 1
    MHC class II integral membrane protein alpha chain 2
    alpha chain
    major histocompatibility complex DAA

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001004521.3 → NP_001004521.3  major histocompatibility complex class II DAA precursor

      Status: VALIDATED

      Source sequence(s)
      CU694380, EH471567, EH496041, EH497754
      UniProtKB/TrEMBL
      Q1MTC7, Q4KM20
      Related
      ENSDARP00000048447.7, ENSDART00000048448.9
      Conserved Domains (2) summary
      smart00920
      Location:21 → 99
      MHC_II_alpha; Class II histocompatibility antigen, alpha domain
      cl11960
      Location:103 → 197
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007119.7 Reference GRCz11 Primary Assembly

      Range
      36471961..36475344 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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