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    nploc4 NPL4 homolog, ubiquitin recognition factor [ Danio rerio (zebrafish) ]

    Gene ID: 327447, updated on 27-Mar-2024

    Summary

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    Official Symbol
    nploc4provided by ZNC
    Official Full Name
    NPL4 homolog, ubiquitin recognition factorprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-5658
    See related
    Ensembl:ENSDARG00000100487 AllianceGenome:ZFIN:ZDB-GENE-030131-5658
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    npl4; zgc:55988; wu:fi11f09
    Summary
    Predicted to enable ubiquitin binding activity and ubiquitin protein ligase binding activity. Predicted to be involved in ubiquitin-dependent protein catabolic process. Predicted to be active in nucleus. Orthologous to human NPLOC4 (NPL4 homolog, ubiquitin recognition factor). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    human mouse all
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    Genomic context

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    See nploc4 in Genome Data Viewer
    Location:
    chromosome: 12
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    106 current GRCz11 (GCF_000002035.6) 12 NC_007123.7 (35955878..35976925, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 12 NC_007123.6 (36261623..36282670, complement)

    Chromosome 12 - NC_007123.7Genomic Context describing neighboring genes Neighboring gene ring finger protein 213b Neighboring gene dynein, axonemal, intermediate chain 2a Neighboring gene phosphodiesterase 6G, cGMP-specific, rod, gamma, paralog b Neighboring gene oxidoreductase-like domain containing 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. The zebrafish gene map defines ancestral vertebrate chromosomes. Woods IG, et al. Genome Res, 2005 Sep. PMID 16109975, Free PMC Article
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin protein ligase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within ubiquitin-dependent protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    nuclear protein localization protein 4 homolog
    Names
    nuclear protein localization 4 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_199807.1 → NP_956101.1  nuclear protein localization protein 4 homolog

      See identical proteins and their annotated locations for NP_956101.1

      Status: PROVISIONAL

      Source sequence(s)
      BC045845
      UniProtKB/TrEMBL
      A0A0R4IGH9, B2GTE1, Q7ZVI8
      Related
      ENSDARP00000133068.1, ENSDART00000165935.2
      Conserved Domains (5) summary
      COG5100
      Location:5 → 576
      NPL4; Nuclear pore protein [Nuclear structure]
      sd00029
      Location:600 → 619
      zf-RanBP2; RanBP2-type Zn finger [structural motif]
      pfam05020
      Location:123 → 261
      zf-NPL4; NPL4 family, putative zinc binding region
      pfam05021
      Location:264 → 572
      NPL4; NPL4 family
      pfam11543
      Location:1 → 79
      UN_NPL4; Nuclear pore localization protein NPL4

    RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007123.7 Reference GRCz11 Primary Assembly

      Range
      35955878..35976925 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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