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    card9 caspase recruitment domain family, member 9 [ Danio rerio (zebrafish) ]

    Gene ID: 796425, updated on 2-Nov-2024

    Summary

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    Official Symbol
    card9provided by ZNC
    Official Full Name
    caspase recruitment domain family, member 9provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-060531-94
    See related
    Ensembl:ENSDARG00000067672 AllianceGenome:ZFIN:ZDB-GENE-060531-94
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    si:dkey-1o2.6
    Summary
    Predicted to be involved in positive regulation of canonical NF-kappaB signal transduction and regulation of immune response. Predicted to act upstream of or within regulation of apoptotic process. Predicted to be part of CBM complex. Is expressed in brain; gill; liver; pleuroperitoneal region; and unfertilized egg. Human ortholog(s) of this gene implicated in primary immunodeficiency disease. Orthologous to human CARD9 (caspase recruitment domain family member 9). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See card9 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 5 NC_007116.7 (51156808..51167466, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 5 NC_007116.6 (50510215..50520621, complement)

    Chromosome 5 - NC_007116.7Genomic Context describing neighboring genes Neighboring gene zgc:194398 Neighboring gene protein-O-mannosyltransferase 1 Neighboring gene coiled-coil domain containing 180 Neighboring gene small nuclear RNA activating complex, polypeptide 4 Neighboring gene endosome associated trafficking regulator 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Macrophage NFATC2 mediates angiogenic signaling during mycobacterial infection. Brewer WJ, et al. Cell Rep, 2022 Dec 13. PMID 36516756, Free PMC Article
    2. NOD-like receptor signaling pathway activation: A potential mechanism underlying negative effects of benzo(α)pyrene on zebrafish. Mai Y, et al. Comp Biochem Physiol C Toxicol Pharmacol, 2021 Feb. PMID 33161151
    3. Structure and expression pattern of teleost caspase recruitment domain (CARD) containing proteins that are potentially involved in NF-kappaB signalling. Chang MX, et al. Dev Comp Immunol, 2010 Jan. PMID 19699229
    4. Deficiency in class III PI3-kinase confers postnatal lethality with IBD-like features in zebrafish. Zhao S, et al. Nat Commun, 2018 Jul 6. PMID 29980668, Free PMC Article
    5. Transcriptome comparison reveals a genetic network regulating the lower temperature limit in fish. Hu P, et al. Sci Rep, 2016 Jun 30. PMID 27356472, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Process Evidence Code Pubs
    involved_in positive regulation of canonical NF-kappaB signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within regulation of apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of CBM complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    caspase recruitment domain-containing protein 9

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001110285.2 → NP_001103755.1  caspase recruitment domain-containing protein 9

      Status: VALIDATED

      Source sequence(s)
      CU856180
      UniProtKB/TrEMBL
      A0A8M1NGG8, A2CE85
      Related
      ENSDARP00000088242.5, ENSDART00000097471.5
      Conserved Domains (1) summary
      cl14633
      Location:16 → 101
      DD; Death Domain Superfamily of protein-protein interaction domains

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007116.7 Reference GRCz11 Primary Assembly

      Range
      51156808..51167466 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_009301789.4 → XP_009300064.1  caspase recruitment domain-containing protein 9 isoform X5

      UniProtKB/TrEMBL
      A0A8M3B2T4
      Conserved Domains (1) summary
      cd08809
      Location:16 → 101
      CARD_CARD9; Caspase activation and recruitment domain of CARD9-like proteins

    2. XM_009301788.4 → XP_009300063.1  caspase recruitment domain-containing protein 9 isoform X3

      UniProtKB/TrEMBL
      A0A8M3ASS5
      Conserved Domains (2) summary
      cd08809
      Location:37 → 122
      CARD_CARD9; Caspase activation and recruitment domain of CARD9-like proteins
      cl23765
      Location:242 → 359
      iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits

    3. XM_009301786.4 → XP_009300061.1  caspase recruitment domain-containing protein 9 isoform X1

      UniProtKB/TrEMBL
      A0A8M3ASN6
      Conserved Domains (2) summary
      cd08809
      Location:37 → 122
      CARD_CARD9; Caspase activation and recruitment domain of CARD9-like proteins
      cl23765
      Location:242 → 359
      iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits

    4. XM_009301787.4 → XP_009300062.1  caspase recruitment domain-containing protein 9 isoform X2

      UniProtKB/TrEMBL
      A0A8M3B9W3
      Conserved Domains (1) summary
      cd08809
      Location:37 → 122
      CARD_CARD9; Caspase activation and recruitment domain of CARD9-like proteins

    5. XM_005165527.5 → XP_005165584.1  caspase recruitment domain-containing protein 9 isoform X4

      UniProtKB/TrEMBL
      A0A8M2BD15
      Conserved Domains (1) summary
      cd08809
      Location:37 → 122
      CARD_CARD9; Caspase activation and recruitment domain of CARD9-like proteins

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018394610.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      287721..296938 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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