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    txndc5 thioredoxin domain containing 5 [ Danio rerio (zebrafish) ]

    Gene ID: 406289, updated on 19-Jun-2024

    Summary

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    Official Symbol
    txndc5provided by ZNC
    Official Full Name
    thioredoxin domain containing 5provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040426-1951
    See related
    Ensembl:ENSDARG00000009342 AllianceGenome:ZFIN:ZDB-GENE-040426-1951
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:66265; wu:fb20a07; wu:fb55b10
    Summary
    Predicted to enable protein disulfide isomerase activity. Predicted to be involved in apoptotic cell clearance. Predicted to be located in endoplasmic reticulum lumen. Orthologous to human TXNDC5 (thioredoxin domain containing 5). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    human mouse all
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    Genomic context

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    See txndc5 in Genome Data Viewer
    Location:
    chromosome: 24
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    106 current GRCz11 (GCF_000002035.6) 24 NC_007135.7 (7941371..7957580, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 24 NC_007135.6 (7912054..7928261, complement)

    Chromosome 24 - NC_007135.7Genomic Context describing neighboring genes Neighboring gene zgc:101569 Neighboring gene bone morphogenetic protein 6 Neighboring gene biogenesis of lysosomal organelles complex-1, subunit 5, muted Neighboring gene orofacial cleft 1 candidate 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Stress-immune responses and DNA protection function of thioredoxin domain containing 12 in zebrafish (Danio rerio). Kulatunga DCM, et al. Fish Shellfish Immunol, 2019 Jan. PMID 30359749
    2. Detection of biomarkers to differentiate endocrine disruption from hepatotoxicity in zebrafish (Danio rerio) using proteomics. Ayobahan SU, et al. Chemosphere, 2020 Feb. PMID 31726584
    3. Stable isotope labeling in zebrafish allows in vivo monitoring of cardiac morphogenesis. Konzer A, et al. Mol Cell Proteomics, 2013 Jun. PMID 23412571, Free PMC Article
    4. The zebrafish gene map defines ancestral vertebrate chromosomes. Woods IG, et al. Genome Res, 2005 Sep. PMID 16109975, Free PMC Article
    5. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC66265

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables protein disulfide isomerase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein disulfide isomerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein folding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum lumen IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    thioredoxin domain-containing protein 5
    XP_005162560.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_213016.2 → NP_998181.2  thioredoxin domain-containing protein 5 precursor

      Status: VALIDATED

      Source sequence(s)
      CR376854

    RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007135.7 Reference GRCz11 Primary Assembly

      Range
      7941371..7957580 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005162503.4 → XP_005162560.1  thioredoxin domain-containing protein 5 isoform X1

      UniProtKB/TrEMBL
      A0A8M2B9N7, F1R184
      Related
      ENSDARP00000116609.1, ENSDART00000145815.2
      Conserved Domains (3) summary
      cd03005
      Location:159 → 259
      PDI_a_ERp46; PDIa family, endoplasmic reticulum protein 46 (ERp46) subfamily; ERp46 is an ER-resident protein containing three redox active TRX domains. Yeast complementation studies show that ERp46 can substitute for protein disulfide isomerase (PDI) function in ...
      TIGR01130
      Location:33 → 403
      ER_PDI_fam; protein disulfide isomerase, eukaryotic
      cl00388
      Location:34 → 133
      Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold
    Nucleotide Protein
    Heading Accession and Version

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