nt5c2a 5'-nucleotidase, cytosolic IIa [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: nt5c2aprovided by ZNC
Official Full Name: 5'-nucleotidase, cytosolic IIaprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-3566
See related: Ensembl:ENSDARG00000039399 AllianceGenome:ZFIN:ZDB-GENE-030131-3566
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: nt5c2; fc36f11; sb:eu835; wu:fc36f11; wu:fc45b10
Summary: Predicted to enable 5'-nucleotidase activity. Predicted to be involved in GMP metabolic process. Predicted to act upstream of or within nucleotide metabolic process. Predicted to be located in cytosol. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 45. Orthologous to human NT5C2 (5'-nucleotidase, cytosolic II). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: human mouse all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: chromosome: 13

Exon count:: 20

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	13	NC_007124.7 (28649758..28674422, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	13	NC_007124.6 (28519308..28543976, complement)

Chromosome 13 - NC_007124.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Markers

fc36f11.y1 (e-PCR)
- UniSTS:193685

fc45b10 (e-PCR)
- UniSTS:189171

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables 5'-nucleotidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables 5'-nucleotidase activity	IEA Inferred from Electronic Annotation more info
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables XMP 5'-nucleosidase activity	IEA Inferred from Electronic Annotation more info
enables catalytic activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nucleoside phosphotransferase activity	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in GMP metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within nucleotide metabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytosol	IEA Inferred from Electronic Annotation more info

General protein information

Go to the top of the page Help

Preferred Names: 5'-nucleotidase, cytosolic IIa

Names: 5'-nucleotidase, cytosolic II

NP_001315429.1

EC 3.1.3.5

XP_005156836.1

EC 3.1.3.5

XP_021336196.1

EC 3.1.3.5

XP_068081024.1

EC 3.1.3.5

XP_068081025.1

EC 3.1.3.5

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001328500.1 → NP_001315429.1 5'-nucleotidase, cytosolic IIa

Status: VALIDATED

Source sequence(s)

AL928951, CK028809, EB931124

UniProtKB/TrEMBL

A0A0R4IET0, A0A8M1P3X3, E7FC21

Related

ENSDARP00000057573.6, ENSDART00000057574.6

Conserved Domains (1) summary

pfam05761
Location:43 → 488

5_nucleotid; 5' nucleotidase family

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007124.7 Reference GRCz11 Primary Assembly

Range

28649758..28674422 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_068224924.1 → XP_068081025.1 5'-nucleotidase, cytosolic IIa isoform X2

Related

ENSDARP00000131719.2, ENSDART00000164508.3
XM_068224923.1 → XP_068081024.1 5'-nucleotidase, cytosolic IIa isoform X1
XM_005156779.5 → XP_005156836.1 5'-nucleotidase, cytosolic IIa isoform X1

See identical proteins and their annotated locations for XP_005156836.1

UniProtKB/TrEMBL

A0A8M2B3I7

Conserved Domains (1) summary

pfam05761
Location:56 → 501

5_nucleotid; 5' nucleotidase family
XM_021480521.2 → XP_021336196.1 5'-nucleotidase, cytosolic IIa isoform X3

UniProtKB/TrEMBL

A0A8M9QJJ3

Conserved Domains (1) summary

pfam05761
Location:12 → 457

5_nucleotid; 5' nucleotidase family

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_201427.1: Suppressed sequence

Description

NM_201427.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.