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    creb3l3l cAMP responsive element binding protein 3-like 3 like [ Danio rerio (zebrafish) ]

    Gene ID: 406853, updated on 25-Apr-2024

    Summary

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    Official Symbol
    creb3l3lprovided by ZNC
    Official Full Name
    cAMP responsive element binding protein 3-like 3 likeprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040426-2942
    See related
    Ensembl:ENSDARG00000020926 AllianceGenome:ZFIN:ZDB-GENE-040426-2942
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    creb3l3; zgc:66452; wu:fj05f07
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to act upstream of or within regulation of transcription, DNA-templated. Predicted to be active in nucleus. Is expressed in central nervous system; liver; notochord; sensory system; and yolk syncytial layer. Orthologous to human CREB3 (cAMP responsive element binding protein 3). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See creb3l3l in Genome Data Viewer
    Location:
    chromosome: 8
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    106 current GRCz11 (GCF_000002035.6) 8 NC_007119.7 (31375119..31384622, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 8 NC_007119.6 (31365887..31375375, complement)

    Chromosome 8 - NC_007119.7Genomic Context describing neighboring genes Neighboring gene un-named hu7912 Neighboring gene growth arrest and DNA-damage-inducible, gamma a Neighboring gene NIM1 serine/threonine protein kinase a Neighboring gene zinc finger protein 131

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Fasted zebrafish mimic genetic and physiological responses in mammals: a model for obesity and diabetes? Craig PM, et al. Zebrafish, 2011 Sep. PMID 21854210
    2. Ovarian senescence increases liver fibrosis in humans and zebrafish with steatosis. Turola E, et al. Dis Model Mech, 2015 Sep. PMID 26183212, Free PMC Article
    3. Gene expression profiles in zebrafish (Danio rerio) liver after acute exposure to okadaic acid. Zhang NS, et al. Environ Toxicol Pharmacol, 2014 Mar. PMID 24637248
    4. Gene expression analysis of zebrafish retinal ganglion cells during optic nerve regeneration identifies KLF6a and KLF7a as important regulators of axon regeneration. Veldman MB, et al. Dev Biol, 2007 Dec 15. PMID 17949705
    5. Olfactory imprinting is correlated with changes in gene expression in the olfactory epithelia of the zebrafish. Harden MV, et al. J Neurobiol, 2006 Nov. PMID 17013923

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    cAMP responsive element binding protein 3-like 3 like; cyclic AMP-responsive element-binding protein 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_213532.2 → NP_998697.2  cAMP responsive element binding protein 3-like 3 like

      See identical proteins and their annotated locations for NP_998697.2

      Status: VALIDATED

      Source sequence(s)
      AL929453, EH441942, EH467829
      UniProtKB/TrEMBL
      A0A8M2BEK7
      Related
      ENSDARP00000024846.8, ENSDART00000024872.9
      Conserved Domains (1) summary
      cd14689
      Location:228 → 288
      bZIP_CREB3; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 3 (CREB3) and similar proteins: a DNA-binding and dimerization domain

    RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007119.7 Reference GRCz11 Primary Assembly

      Range
      31375119..31384622 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005167154.3 → XP_005167211.1  cyclic AMP-responsive element-binding protein 3 isoform X1

      See identical proteins and their annotated locations for XP_005167211.1

      UniProtKB/TrEMBL
      A0A8M2BEK7
      Conserved Domains (1) summary
      cd14689
      Location:228 → 288
      bZIP_CREB3; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 3 (CREB3) and similar proteins: a DNA-binding and dimerization domain

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018394733.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      131880..141311 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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    Research Materials