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    med17 mediator complex subunit 17 [ Danio rerio (zebrafish) ]

    Gene ID: 567560, updated on 2-Nov-2024

    Summary

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    Official Symbol
    med17provided by ZNC
    Official Full Name
    mediator complex subunit 17provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040302-1
    See related
    AllianceGenome:ZFIN:ZDB-GENE-040302-1
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    crsp6; zgc:73307; zgc:153983
    Summary
    Predicted to enable transcription coregulator activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Predicted to be part of core mediator complex and mediator complex. Human ortholog(s) of this gene implicated in infantile cerebral and cerebellar atrophy with postnatal progressive microcephaly. Orthologous to human MED17 (mediator complex subunit 17). [provided by Alliance of Genome Resources, Nov 2024]
    Annotation information
    Annotation category: partial on reference assembly
    Orthologs
    human mouse all
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    Genomic context

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    See med17 in Genome Data Viewer
    Location:
    chromosome: 15
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 15 NC_007126.7 (436776..447971)
    105 previous assembly GRCz10 (GCF_000002035.5) 15 NC_007126.6 (161539..172734)

    Chromosome 15 - NC_007126.7Genomic Context describing neighboring genes Neighboring gene nipsnap homolog 2 Neighboring gene phosphoserine phosphatase Neighboring gene centrosomal protein 295 Neighboring gene V-set and transmembrane domain containing 5 Neighboring gene uncharacterized LOC100002960

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Pannexin 1 ohnologs in the teleost lineage. Bond SR, et al. J Membr Biol, 2012 Aug. PMID 22922822
    2. A subunit of the mediator complex regulates vertebrate neuronal development. Wang X, et al. Proc Natl Acad Sci U S A, 2006 Nov 14. PMID 17088561, Free PMC Article
    3. Expression of Protein-Coding Gene Orthologs in Zebrafish and Mouse Inner Ear Non-sensory Supporting Cells. Giffen KP, et al. Front Neurosci, 2019. PMID 31680844, Free PMC Article
    4. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. This paper demonstrates a regulatory role of motionless/Med12 in vertebrate neuronal development.
      Title: A subunit of the mediator complex regulates vertebrate neuronal development.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC73307, MGC153983

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables transcription coregulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transcription coregulator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of core mediator complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of mediator complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of mediator complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    mediator of RNA polymerase II transcription subunit 17
    Names
    CRSP complex subunit 6
    cofactor required for Sp1 transcriptional activation, subunit 6

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001077574.1 → NP_001071042.1  mediator of RNA polymerase II transcription subunit 17

      See identical proteins and their annotated locations for NP_001071042.1

      Status: PROVISIONAL

      Source sequence(s)
      BC124507
      UniProtKB/Swiss-Prot
      Q08BY1
      UniProtKB/TrEMBL
      B2GSS8
      Conserved Domains (1) summary
      pfam10156
      Location:143 → 427
      Med17; Subunit 17 of Mediator complex

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007126.7 Reference GRCz11 Primary Assembly

      Range
      436776..447971
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q08BY1.1 GenPept UniProtKB/Swiss-Prot:Q08BY1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.