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    uncharacterized protein [ Saccharomyces cerevisiae S288C ]

    Gene ID: 850673, updated on 2-Nov-2024

    Summary

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    Official Full Name
    uncharacterized protein
    Primary source
    SGD:S000003976
    Locus tag
    YLL053C
    See related
    AllianceGenome:SGD:S000003976; FungiDB:YLL053C; VEuPathDB:YLL053C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to enable water channel activity. Predicted to be involved in transmembrane transport and water transport. Predicted to be located in membrane. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in cataract and cataract 15 multiple types. Orthologous to human AQP6 (aquaporin 6) and MIP (major intrinsic protein of lens fiber). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    Location:
    chromosome: XII
    Exon count:
    1
    Sequence:
    Chromosome: XII; NC_001144.5 (35503..35961, complement)

    Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene Yct1p Neighboring gene uncharacterized protein Neighboring gene Aqy2p Neighboring gene putative ferric-chelate reductase Neighboring gene cofilin

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001144.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Polymorphism of Saccharomyces cerevisiae aquaporins. Laizé V, et al. Yeast, 2000 Jul. PMID 10870101
    2. Existence of a tightly regulated water channel in Saccharomyces cerevisiae. Meyrial V, et al. Eur J Biochem, 2001 Jan. PMID 11168368
    3. Aquaporins in Saccharomyces: Characterization of a second functional water channel protein. Carbrey JM, et al. Proc Natl Acad Sci U S A, 2001 Jan 30. PMID 11158584, Free PMC Article
    4. Aquaporin expression correlates with freeze tolerance in baker's yeast, and overexpression improves freeze tolerance in industrial strains. Tanghe A, et al. Appl Environ Microbiol, 2002 Dec. PMID 12450819, Free PMC Article
    5. Functional analysis of eight open reading frames on chromosomes XII and XIV of Saccharomyces cerevisiae. Ahmed Khan S, et al. Yeast, 2000 Dec. PMID 11113969

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables water channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in water transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    NP_013047.1
    • Putative protein; in the Sigma 1278B strain background YLL053C is contiguous with AQY2 which encodes an aquaporin

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001144.5 Reference assembly

      Range
      35503..35961 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181873.1 → NP_013047.1  TPA: uncharacterized protein YLL053C [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013047.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A7A0K7, B3LTC4, C7GNE2, C8ZCS2, D6VXV5, P0CD98
      Conserved Domains (1) summary
      cl00200
      Location:1 → 133
      MIP; Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P0CD98.1

    Gene LinkOut

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